The regulation of IL-10 production by immune cells
| Main Author: | |
|---|---|
| Publication Date: | 2010 |
| Other Authors: | |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Download full: | http://hdl.handle.net/1822/29592 |
Summary: | Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention. |
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The regulation of IL-10 production by immune cellsScience & TechnologyInterleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.Nature Publishing GroupUniversidade do MinhoSaraiva, MargaridaO'Garra, Anne2010-032010-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29592eng1474-173310.1038/nri271120154735info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:00Zoai:repositorium.sdum.uminho.pt:1822/29592Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:30.732114Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The regulation of IL-10 production by immune cells |
| title |
The regulation of IL-10 production by immune cells |
| spellingShingle |
The regulation of IL-10 production by immune cells Saraiva, Margarida Science & Technology |
| title_short |
The regulation of IL-10 production by immune cells |
| title_full |
The regulation of IL-10 production by immune cells |
| title_fullStr |
The regulation of IL-10 production by immune cells |
| title_full_unstemmed |
The regulation of IL-10 production by immune cells |
| title_sort |
The regulation of IL-10 production by immune cells |
| author |
Saraiva, Margarida |
| author_facet |
Saraiva, Margarida O'Garra, Anne |
| author_role |
author |
| author2 |
O'Garra, Anne |
| author2_role |
author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Saraiva, Margarida O'Garra, Anne |
| dc.subject.por.fl_str_mv |
Science & Technology |
| topic |
Science & Technology |
| description |
Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention. |
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2010 |
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2010-03 2010-03-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1822/29592 |
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http://hdl.handle.net/1822/29592 |
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eng |
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eng |
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1474-1733 10.1038/nri2711 20154735 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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