3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/4685 |
Resumo: | Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient’s quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection. To vanquish these drawbacks, researchers from tissue engineering area are currently using computer-aided design models or medical data to produce 3D scaffolds by Rapid Prototyping (RP). Herein, Tricalcium phosphate (TCP)/Sodium Alginate (SA) scaffolds were produced using RP and subsequently functionalized with silver nanoparticles (AgNPs) through two different incorporation methods. The obtained results revealed that the composite scaffolds produced by direct incorporation of AgNPs are the most suitable for being used in bone tissue regeneration since they present appropriate mechanical properties, biocompatibility and bactericidal activity. |
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3D Printed scaffolds with bactericidal activity aimed for bone tissue regenerationBactericidal activityBone regenerationSilver nanoparticlesRapid prototyping (RP)Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient’s quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection. To vanquish these drawbacks, researchers from tissue engineering area are currently using computer-aided design models or medical data to produce 3D scaffolds by Rapid Prototyping (RP). Herein, Tricalcium phosphate (TCP)/Sodium Alginate (SA) scaffolds were produced using RP and subsequently functionalized with silver nanoparticles (AgNPs) through two different incorporation methods. The obtained results revealed that the composite scaffolds produced by direct incorporation of AgNPs are the most suitable for being used in bone tissue regeneration since they present appropriate mechanical properties, biocompatibility and bactericidal activity.ElsevieruBibliorumCorreia, Tiago R.Figueira, Daniela Sofia RodriguesSá, KevinMiguel, Sónia P.Fradique, Ricardo GilMendonça, AntónioCorreia, I.J.2018-03-21T12:19:26Z2016-06-032016-06-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4685engCorreia, T. R., Figueira, D. R., de Sá, K. D., Miguel, S. P., Fradique, R. G., Mendonça, A. G., e Correia, I. J. (2016) “3D printed scaffolds with bactericidal activity aimed for bone tissue regeneration.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1432-144510.1016/j.ijbiomac.2016.06.004metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T02:30:32Zoai:ubibliorum.ubi.pt:10400.6/4685Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.368804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
title |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
spellingShingle |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration Correia, Tiago R. Bactericidal activity Bone regeneration Silver nanoparticles Rapid prototyping (RP) |
title_short |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
title_full |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
title_fullStr |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
title_full_unstemmed |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
title_sort |
3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration |
author |
Correia, Tiago R. |
author_facet |
Correia, Tiago R. Figueira, Daniela Sofia Rodrigues Sá, Kevin Miguel, Sónia P. Fradique, Ricardo Gil Mendonça, António Correia, I.J. |
author_role |
author |
author2 |
Figueira, Daniela Sofia Rodrigues Sá, Kevin Miguel, Sónia P. Fradique, Ricardo Gil Mendonça, António Correia, I.J. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Correia, Tiago R. Figueira, Daniela Sofia Rodrigues Sá, Kevin Miguel, Sónia P. Fradique, Ricardo Gil Mendonça, António Correia, I.J. |
dc.subject.por.fl_str_mv |
Bactericidal activity Bone regeneration Silver nanoparticles Rapid prototyping (RP) |
topic |
Bactericidal activity Bone regeneration Silver nanoparticles Rapid prototyping (RP) |
description |
Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient’s quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection. To vanquish these drawbacks, researchers from tissue engineering area are currently using computer-aided design models or medical data to produce 3D scaffolds by Rapid Prototyping (RP). Herein, Tricalcium phosphate (TCP)/Sodium Alginate (SA) scaffolds were produced using RP and subsequently functionalized with silver nanoparticles (AgNPs) through two different incorporation methods. The obtained results revealed that the composite scaffolds produced by direct incorporation of AgNPs are the most suitable for being used in bone tissue regeneration since they present appropriate mechanical properties, biocompatibility and bactericidal activity. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-03 2016-06-03T00:00:00Z 2018-03-21T12:19:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/4685 |
url |
http://hdl.handle.net/10400.6/4685 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia, T. R., Figueira, D. R., de Sá, K. D., Miguel, S. P., Fradique, R. G., Mendonça, A. G., e Correia, I. J. (2016) “3D printed scaffolds with bactericidal activity aimed for bone tissue regeneration.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1432-1445 10.1016/j.ijbiomac.2016.06.004 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136354518433792 |