CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/42766 |
Resumo: | Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell typesImmunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells.Veritati - Repositório Institucional da Universidade Católica PortuguesaBarros, LeandroPiontkivska, DarynaFigueiredo-Campos, PatríciaFanczal, JúliaRibeiro, Sofia PereiraBaptista, MartaAriotti, SilviaSantos, NunoAmorim, Maria JoãoPereira, Cristina SilvaVeldhoen, MarcFerreira, Cristina2023-10-04T13:43:17Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/42766eng2041-172310.1038/s41467-023-41364-w85170632511PMC1049532737696824491A-6426-F006/3346542001163289500002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-05T01:36:40Zoai:repositorio.ucp.pt:10400.14/42766Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:34:06.031329Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
title |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
spellingShingle |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types Barros, Leandro |
title_short |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
title_full |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
title_fullStr |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
title_full_unstemmed |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
title_sort |
CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types |
author |
Barros, Leandro |
author_facet |
Barros, Leandro Piontkivska, Daryna Figueiredo-Campos, Patrícia Fanczal, Júlia Ribeiro, Sofia Pereira Baptista, Marta Ariotti, Silvia Santos, Nuno Amorim, Maria João Pereira, Cristina Silva Veldhoen, Marc Ferreira, Cristina |
author_role |
author |
author2 |
Piontkivska, Daryna Figueiredo-Campos, Patrícia Fanczal, Júlia Ribeiro, Sofia Pereira Baptista, Marta Ariotti, Silvia Santos, Nuno Amorim, Maria João Pereira, Cristina Silva Veldhoen, Marc Ferreira, Cristina |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Barros, Leandro Piontkivska, Daryna Figueiredo-Campos, Patrícia Fanczal, Júlia Ribeiro, Sofia Pereira Baptista, Marta Ariotti, Silvia Santos, Nuno Amorim, Maria João Pereira, Cristina Silva Veldhoen, Marc Ferreira, Cristina |
description |
Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-04T13:43:17Z 2023-12 2023-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/42766 |
url |
http://hdl.handle.net/10400.14/42766 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 10.1038/s41467-023-41364-w 85170632511 PMC10495327 37696824 491A-6426-F006/3346542 001163289500002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133606276235264 |