Universal strategy for designing shape memory hydrogels
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/34414 |
Resumo: | Smart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein, we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. As a proofof-concept, a thermoresponsive polyurethane mesh was embedded within a methacrylated chitosan (CHTMA), gelatin (GELMA), laminarin (LAMMA) or hyaluronic acid (HAMMA) hydrogel networks which allowed to obtain hydrogel composites with shape memory ability. With this system, we achieved good to excellent shape fixity ratios (50-90%) and excellent shape recovery ratios (~ 100%, almost instantaneously) at body temperature (37 °C). Cytocompatibility tests demonstrated good viability either with cells on top or encapsulated during all shape memory processes. This straightforward approach opens a broad range of possibilities to convey shape memory properties to, virtually, any synthetic or natural-based hydrogel for several biological and non-biological applications. |
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Universal strategy for designing shape memory hydrogelsSmart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein, we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. As a proofof-concept, a thermoresponsive polyurethane mesh was embedded within a methacrylated chitosan (CHTMA), gelatin (GELMA), laminarin (LAMMA) or hyaluronic acid (HAMMA) hydrogel networks which allowed to obtain hydrogel composites with shape memory ability. With this system, we achieved good to excellent shape fixity ratios (50-90%) and excellent shape recovery ratios (~ 100%, almost instantaneously) at body temperature (37 °C). Cytocompatibility tests demonstrated good viability either with cells on top or encapsulated during all shape memory processes. This straightforward approach opens a broad range of possibilities to convey shape memory properties to, virtually, any synthetic or natural-based hydrogel for several biological and non-biological applications.American Chemical Society2023-04-04T00:00:00Z2022-04-04T00:00:00Z2022-04-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34414eng10.1021/acsmaterialslett.2c00107Costa, Dora C. S.Costa, Patrícia D. C.Gomes, Maria C.Chandrakar, AmitWieringa, Paul A.Moroni, LorenzoMano, João F.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:28Zoai:ria.ua.pt:10773/34414Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:45.176866Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Universal strategy for designing shape memory hydrogels |
title |
Universal strategy for designing shape memory hydrogels |
spellingShingle |
Universal strategy for designing shape memory hydrogels Costa, Dora C. S. |
title_short |
Universal strategy for designing shape memory hydrogels |
title_full |
Universal strategy for designing shape memory hydrogels |
title_fullStr |
Universal strategy for designing shape memory hydrogels |
title_full_unstemmed |
Universal strategy for designing shape memory hydrogels |
title_sort |
Universal strategy for designing shape memory hydrogels |
author |
Costa, Dora C. S. |
author_facet |
Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. |
author_role |
author |
author2 |
Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. |
description |
Smart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein, we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. As a proofof-concept, a thermoresponsive polyurethane mesh was embedded within a methacrylated chitosan (CHTMA), gelatin (GELMA), laminarin (LAMMA) or hyaluronic acid (HAMMA) hydrogel networks which allowed to obtain hydrogel composites with shape memory ability. With this system, we achieved good to excellent shape fixity ratios (50-90%) and excellent shape recovery ratios (~ 100%, almost instantaneously) at body temperature (37 °C). Cytocompatibility tests demonstrated good viability either with cells on top or encapsulated during all shape memory processes. This straightforward approach opens a broad range of possibilities to convey shape memory properties to, virtually, any synthetic or natural-based hydrogel for several biological and non-biological applications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-04T00:00:00Z 2022-04-04 2023-04-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/34414 |
url |
http://hdl.handle.net/10773/34414 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1021/acsmaterialslett.2c00107 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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