Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease

• Autor(a) principal: Matos, Andreia Carvalho de
• Data de Publicação: 2022
• Outros Autores: Macedo, Cristiane Pais, Mendes, Patrícia Afonso, Cipriano, Maria Augusta, Paiva, Artur, Simão, Adélia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/101195; https://doi.org/10.1159/000516940
• topic: Autoimmune hepatitis; Nitrofurantoin toxicity; Interstitial pulmonary disease; Hepatite autoimmune; Toxicidade a nitrofurantoína; Doença pulmonar intersticial

Antibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin- induced autoimmune hepatitis and lung fibrosis that fulfills the definitive clinical criteria for diagnosis, presenting histological, imagiological, and immunological evidence of nitrofurantoin-induced toxicity. It occurred in a 68-year-old woman with extended nitrofurantoin intake for urinary tract infection prophylaxis who presented with progressive exercise dyspnea and jaundice. Similar published cases are also reviewed in this article.