Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
| Autor(a) principal: | |
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| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/6333 |
Resumo: | Burden of AMR Collaborative Group:National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal (Prof M Caniça PhD, Vera Manageiro PhD) |
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Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysisAntibiotic-resistant BacteriaDeathsDisability-adjusted life-yearsEuropean UnionEuropean Economic AreaResistência aos AntimicrobianosBurden of AMR Collaborative Group:National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal (Prof M Caniça PhD, Vera Manageiro PhD)Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300481/Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs). Methods: We estimated the incidence of infections with 16 antibiotic resistance–bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011–12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature. Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148–763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480–38 430) attributable deaths and 874 541 (768 837–989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece. Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.European Centre for Disease Prevention and ControlElsevier/ LancetRepositório Científico do Instituto Nacional de SaúdeCassini, AlessandroHögberg, Liselotte DiazPlachouras, DiamantisQuattrocchi, AnnalisaHoxha, AnaSimonsen, Gunnar SkovColomb-Cotinat, MélanieKretzschmar, Mirjam E.Devleesschauwer, BrechtCecchini, MicheleOuakrim, Driss AitOliveira, Tiago CravoStruelens, Marc J.Suetens, CarlMonnet, Dominique L.Strauss, ReinhildMertens, KarlStruyf, ThomasCatry, BoudewijnLatour, KatrienIvanov, Ivan N.Dobreva, Elina G.Tambic Andraševic, ArjanaSoprek, SilvijaBudimir, AnaPaphitou, NikiŽemlicková, HelenaSchytte Olsen, StefanWolff Sönksen, UteMärtin, PilleIvanova, MarinaLyytikäinen, OutiJalava, JariCoignard, BrunoEckmanns, TimAbu Sin, MunaHaller, SebastianDaikos, George L.Gikas, AchilleasTsiodras, SotiriosKontopidou, FloraTóth, ÁkosHajdu, ÁgnesGuólaugsson, ÓlafurKristinsson, Karl G.Murchan, StephenBurns, KarenPezzotti, PatrizioGagliotti, CarloDumpis, UgaLiuimiene, AgnePerrin, MoniqueBorg, Michael A.de Greeff, Sabine C.Monen, Jos C.M.Koek, Mayke B.G.Elstrøm, PetterZabicka, DorotaDeptula, AleksanderHryniewicz, WaleriaCaniça, ManuelaNogueira, Paulo JorgeFernandes, Paulo AndréManageiro, VeraPopescu, Gabriel A.Serban, Roxana I.Schréterová, EvaLitvová, SlavkaŠtefkovicová, MáriaKolman, JanaKlavs, IrenaKorošec, AlešAracil, BelénAsensio, AngelPérez-Vázquez, MaríaBillström, HannaLarsson, SofieReilly, Jacqui S.Johnson, AlanHopkins, Susan2019-03-28T13:41:59Z2018-11-052018-11-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6333engLancet Infect Dis. 2019 Jan;19(1):56-66. doi: 10.1016/S1473-3099(18)30605-4. Epub 2018 Nov 51473-309910.1016/S1473-3099(18)30605-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:21Zoai:repositorio.insa.pt:10400.18/6333Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:59.058184Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| title |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| spellingShingle |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis Cassini, Alessandro Antibiotic-resistant Bacteria Deaths Disability-adjusted life-years European Union European Economic Area Resistência aos Antimicrobianos |
| title_short |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| title_full |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| title_fullStr |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| title_full_unstemmed |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| title_sort |
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis |
| author |
Cassini, Alessandro |
| author_facet |
Cassini, Alessandro Högberg, Liselotte Diaz Plachouras, Diamantis Quattrocchi, Annalisa Hoxha, Ana Simonsen, Gunnar Skov Colomb-Cotinat, Mélanie Kretzschmar, Mirjam E. Devleesschauwer, Brecht Cecchini, Michele Ouakrim, Driss Ait Oliveira, Tiago Cravo Struelens, Marc J. Suetens, Carl Monnet, Dominique L. Strauss, Reinhild Mertens, Karl Struyf, Thomas Catry, Boudewijn Latour, Katrien Ivanov, Ivan N. Dobreva, Elina G. Tambic Andraševic, Arjana Soprek, Silvija Budimir, Ana Paphitou, Niki Žemlicková, Helena Schytte Olsen, Stefan Wolff Sönksen, Ute Märtin, Pille Ivanova, Marina Lyytikäinen, Outi Jalava, Jari Coignard, Bruno Eckmanns, Tim Abu Sin, Muna Haller, Sebastian Daikos, George L. Gikas, Achilleas Tsiodras, Sotirios Kontopidou, Flora Tóth, Ákos Hajdu, Ágnes Guólaugsson, Ólafur Kristinsson, Karl G. Murchan, Stephen Burns, Karen Pezzotti, Patrizio Gagliotti, Carlo Dumpis, Uga Liuimiene, Agne Perrin, Monique Borg, Michael A. de Greeff, Sabine C. Monen, Jos C.M. Koek, Mayke B.G. Elstrøm, Petter Zabicka, Dorota Deptula, Aleksander Hryniewicz, Waleria Caniça, Manuela Nogueira, Paulo Jorge Fernandes, Paulo André Manageiro, Vera Popescu, Gabriel A. Serban, Roxana I. Schréterová, Eva Litvová, Slavka Štefkovicová, Mária Kolman, Jana Klavs, Irena Korošec, Aleš Aracil, Belén Asensio, Angel Pérez-Vázquez, María Billström, Hanna Larsson, Sofie Reilly, Jacqui S. Johnson, Alan Hopkins, Susan |
| author_role |
author |
| author2 |
Högberg, Liselotte Diaz Plachouras, Diamantis Quattrocchi, Annalisa Hoxha, Ana Simonsen, Gunnar Skov Colomb-Cotinat, Mélanie Kretzschmar, Mirjam E. Devleesschauwer, Brecht Cecchini, Michele Ouakrim, Driss Ait Oliveira, Tiago Cravo Struelens, Marc J. Suetens, Carl Monnet, Dominique L. Strauss, Reinhild Mertens, Karl Struyf, Thomas Catry, Boudewijn Latour, Katrien Ivanov, Ivan N. Dobreva, Elina G. Tambic Andraševic, Arjana Soprek, Silvija Budimir, Ana Paphitou, Niki Žemlicková, Helena Schytte Olsen, Stefan Wolff Sönksen, Ute Märtin, Pille Ivanova, Marina Lyytikäinen, Outi Jalava, Jari Coignard, Bruno Eckmanns, Tim Abu Sin, Muna Haller, Sebastian Daikos, George L. Gikas, Achilleas Tsiodras, Sotirios Kontopidou, Flora Tóth, Ákos Hajdu, Ágnes Guólaugsson, Ólafur Kristinsson, Karl G. Murchan, Stephen Burns, Karen Pezzotti, Patrizio Gagliotti, Carlo Dumpis, Uga Liuimiene, Agne Perrin, Monique Borg, Michael A. de Greeff, Sabine C. Monen, Jos C.M. Koek, Mayke B.G. Elstrøm, Petter Zabicka, Dorota Deptula, Aleksander Hryniewicz, Waleria Caniça, Manuela Nogueira, Paulo Jorge Fernandes, Paulo André Manageiro, Vera Popescu, Gabriel A. Serban, Roxana I. Schréterová, Eva Litvová, Slavka Štefkovicová, Mária Kolman, Jana Klavs, Irena Korošec, Aleš Aracil, Belén Asensio, Angel Pérez-Vázquez, María Billström, Hanna Larsson, Sofie Reilly, Jacqui S. Johnson, Alan Hopkins, Susan |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Cassini, Alessandro Högberg, Liselotte Diaz Plachouras, Diamantis Quattrocchi, Annalisa Hoxha, Ana Simonsen, Gunnar Skov Colomb-Cotinat, Mélanie Kretzschmar, Mirjam E. Devleesschauwer, Brecht Cecchini, Michele Ouakrim, Driss Ait Oliveira, Tiago Cravo Struelens, Marc J. Suetens, Carl Monnet, Dominique L. Strauss, Reinhild Mertens, Karl Struyf, Thomas Catry, Boudewijn Latour, Katrien Ivanov, Ivan N. Dobreva, Elina G. Tambic Andraševic, Arjana Soprek, Silvija Budimir, Ana Paphitou, Niki Žemlicková, Helena Schytte Olsen, Stefan Wolff Sönksen, Ute Märtin, Pille Ivanova, Marina Lyytikäinen, Outi Jalava, Jari Coignard, Bruno Eckmanns, Tim Abu Sin, Muna Haller, Sebastian Daikos, George L. Gikas, Achilleas Tsiodras, Sotirios Kontopidou, Flora Tóth, Ákos Hajdu, Ágnes Guólaugsson, Ólafur Kristinsson, Karl G. Murchan, Stephen Burns, Karen Pezzotti, Patrizio Gagliotti, Carlo Dumpis, Uga Liuimiene, Agne Perrin, Monique Borg, Michael A. de Greeff, Sabine C. Monen, Jos C.M. Koek, Mayke B.G. Elstrøm, Petter Zabicka, Dorota Deptula, Aleksander Hryniewicz, Waleria Caniça, Manuela Nogueira, Paulo Jorge Fernandes, Paulo André Manageiro, Vera Popescu, Gabriel A. Serban, Roxana I. Schréterová, Eva Litvová, Slavka Štefkovicová, Mária Kolman, Jana Klavs, Irena Korošec, Aleš Aracil, Belén Asensio, Angel Pérez-Vázquez, María Billström, Hanna Larsson, Sofie Reilly, Jacqui S. Johnson, Alan Hopkins, Susan |
| dc.subject.por.fl_str_mv |
Antibiotic-resistant Bacteria Deaths Disability-adjusted life-years European Union European Economic Area Resistência aos Antimicrobianos |
| topic |
Antibiotic-resistant Bacteria Deaths Disability-adjusted life-years European Union European Economic Area Resistência aos Antimicrobianos |
| description |
Burden of AMR Collaborative Group:National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal (Prof M Caniça PhD, Vera Manageiro PhD) |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-11-05 2018-11-05T00:00:00Z 2019-03-28T13:41:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/6333 |
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http://hdl.handle.net/10400.18/6333 |
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eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Lancet Infect Dis. 2019 Jan;19(1):56-66. doi: 10.1016/S1473-3099(18)30605-4. Epub 2018 Nov 5 1473-3099 10.1016/S1473-3099(18)30605-4 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier/ Lancet |
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Elsevier/ Lancet |
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