The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression

Detalhes bibliográficos
Autor(a) principal: Moreira, AM
Data de Publicação: 2020
Outros Autores: Pereira, J, Melo, S, Fernandes, MS, Carneiro, P, Seruca, R, Figueiredo, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/145265
Resumo: The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer.
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spelling The Extracellular Matrix: An Accomplice in Gastric Cancer Development and ProgressionCell-ECM interactionECM biomarkersECM deregulationECM targetingExtracellular matrixGastric cancerIntegrinThe extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/145265eng2073-440910.3390/cells9020394Moreira, AMPereira, JMelo, SFernandes, MSCarneiro, PSeruca, RFigueiredo, Jinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-26T14:30:26ZPortal AgregadorONG
dc.title.none.fl_str_mv The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
title The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
spellingShingle The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
Moreira, AM
Cell-ECM interaction
ECM biomarkers
ECM deregulation
ECM targeting
Extracellular matrix
Gastric cancer
Integrin
title_short The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
title_full The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
title_fullStr The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
title_full_unstemmed The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
title_sort The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
author Moreira, AM
author_facet Moreira, AM
Pereira, J
Melo, S
Fernandes, MS
Carneiro, P
Seruca, R
Figueiredo, J
author_role author
author2 Pereira, J
Melo, S
Fernandes, MS
Carneiro, P
Seruca, R
Figueiredo, J
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, AM
Pereira, J
Melo, S
Fernandes, MS
Carneiro, P
Seruca, R
Figueiredo, J
dc.subject.por.fl_str_mv Cell-ECM interaction
ECM biomarkers
ECM deregulation
ECM targeting
Extracellular matrix
Gastric cancer
Integrin
topic Cell-ECM interaction
ECM biomarkers
ECM deregulation
ECM targeting
Extracellular matrix
Gastric cancer
Integrin
description The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/145265
url https://hdl.handle.net/10216/145265
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
10.3390/cells9020394
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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