Predictive value of D-dimer in the clinical outcome of severe COVID19 patients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/133570 |
Resumo: | BACKGROUND: COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality. PURPOSE: To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality. METHODS: Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV). RESULTS: 118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables. CONCLUSIONS: In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity. |
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7160 |
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Predictive value of D-dimer in the clinical outcome of severe COVID19 patientsAre we giving it too much credit?COVID19critical careD-dimermortality rateHematologyBACKGROUND: COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality. PURPOSE: To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality. METHODS: Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV). RESULTS: 118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables. CONCLUSIONS: In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCidade, José P.Coelho, LuísCosta, VascoMorais, RuiMoniz, PatríciaMorais, LuísFidalgo, PedroTralhão, AntónioPaulino, CarolinaNora, DavidValerio, BernardinoMendes, VítorTapadinhas, CamilaPovoa, Pedro2022-02-24T23:23:14Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/133570eng1076-0296PURE: 41933243https://doi.org/10.1177/10760296221079612info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:19Zoai:run.unl.pt:10362/133570Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:51.099636Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients Are we giving it too much credit? |
title |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
spellingShingle |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients Cidade, José P. COVID19 critical care D-dimer mortality rate Hematology |
title_short |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
title_full |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
title_fullStr |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
title_full_unstemmed |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
title_sort |
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients |
author |
Cidade, José P. |
author_facet |
Cidade, José P. Coelho, Luís Costa, Vasco Morais, Rui Moniz, Patrícia Morais, Luís Fidalgo, Pedro Tralhão, António Paulino, Carolina Nora, David Valerio, Bernardino Mendes, Vítor Tapadinhas, Camila Povoa, Pedro |
author_role |
author |
author2 |
Coelho, Luís Costa, Vasco Morais, Rui Moniz, Patrícia Morais, Luís Fidalgo, Pedro Tralhão, António Paulino, Carolina Nora, David Valerio, Bernardino Mendes, Vítor Tapadinhas, Camila Povoa, Pedro |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Comprehensive Health Research Centre (CHRC) - pólo NMS NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Cidade, José P. Coelho, Luís Costa, Vasco Morais, Rui Moniz, Patrícia Morais, Luís Fidalgo, Pedro Tralhão, António Paulino, Carolina Nora, David Valerio, Bernardino Mendes, Vítor Tapadinhas, Camila Povoa, Pedro |
dc.subject.por.fl_str_mv |
COVID19 critical care D-dimer mortality rate Hematology |
topic |
COVID19 critical care D-dimer mortality rate Hematology |
description |
BACKGROUND: COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality. PURPOSE: To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality. METHODS: Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV). RESULTS: 118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables. CONCLUSIONS: In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-24T23:23:14Z 2022-01 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/133570 |
url |
http://hdl.handle.net/10362/133570 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1076-0296 PURE: 41933243 https://doi.org/10.1177/10760296221079612 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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