The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus

Detalhes bibliográficos
Autor(a) principal: Oliveira, Marco
Data de Publicação: 2023
Outros Autores: Soares, Silvia, Sá, Sara, Gestoso, Álvaro, Correa-Duarte, Miguel, Baylina, Pilar, Fernandes, Rúben, Pereira, Carla F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/42918
Resumo: Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirmed through UV-Vis spectroscopy, exhibiting a characteristic peak within the 500–600 nm wavelength range, and the evaluation of the main functional groups and morphology were stressed by Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM), respectively. Subsequently, the synthesized bAuNPs were combined with low concentrations of ampicillin and evaluated against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) through the classical serial dilution method. This innovative approach holds the potential to address the escalating issue of antibiotic resistance, providing a viable and sustainable solution.
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spelling The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureusAmpicillinAntibiotic resistanceBiosynthetic gold nanoparticlesSynergismGold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirmed through UV-Vis spectroscopy, exhibiting a characteristic peak within the 500–600 nm wavelength range, and the evaluation of the main functional groups and morphology were stressed by Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM), respectively. Subsequently, the synthesized bAuNPs were combined with low concentrations of ampicillin and evaluated against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) through the classical serial dilution method. This innovative approach holds the potential to address the escalating issue of antibiotic resistance, providing a viable and sustainable solution.Veritati - Repositório Institucional da Universidade Católica PortuguesaOliveira, MarcoSoares, SilviaSá, SaraGestoso, ÁlvaroCorrea-Duarte, MiguelBaylina, PilarFernandes, RúbenPereira, Carla F.2023-10-26T16:50:50Z2023-102023-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/42918eng7660771710.3390/app13191093485174172604001086221300001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-07T01:33:09Zoai:repositorio.ucp.pt:10400.14/42918Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:09.055870Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
title The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
spellingShingle The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
Oliveira, Marco
Ampicillin
Antibiotic resistance
Biosynthetic gold nanoparticles
Synergism
title_short The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
title_full The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
title_fullStr The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
title_full_unstemmed The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
title_sort The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism against staphylococcus aureus
author Oliveira, Marco
author_facet Oliveira, Marco
Soares, Silvia
Sá, Sara
Gestoso, Álvaro
Correa-Duarte, Miguel
Baylina, Pilar
Fernandes, Rúben
Pereira, Carla F.
author_role author
author2 Soares, Silvia
Sá, Sara
Gestoso, Álvaro
Correa-Duarte, Miguel
Baylina, Pilar
Fernandes, Rúben
Pereira, Carla F.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Oliveira, Marco
Soares, Silvia
Sá, Sara
Gestoso, Álvaro
Correa-Duarte, Miguel
Baylina, Pilar
Fernandes, Rúben
Pereira, Carla F.
dc.subject.por.fl_str_mv Ampicillin
Antibiotic resistance
Biosynthetic gold nanoparticles
Synergism
topic Ampicillin
Antibiotic resistance
Biosynthetic gold nanoparticles
Synergism
description Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirmed through UV-Vis spectroscopy, exhibiting a characteristic peak within the 500–600 nm wavelength range, and the evaluation of the main functional groups and morphology were stressed by Fourier Transform Infrared Spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM), respectively. Subsequently, the synthesized bAuNPs were combined with low concentrations of ampicillin and evaluated against Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) through the classical serial dilution method. This innovative approach holds the potential to address the escalating issue of antibiotic resistance, providing a viable and sustainable solution.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-26T16:50:50Z
2023-10
2023-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/42918
url http://hdl.handle.net/10400.14/42918
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 76607717
10.3390/app131910934
85174172604
001086221300001
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eu_rights_str_mv openAccess
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