Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules

Detalhes bibliográficos
Autor(a) principal: Tavares, Ana P. M.
Data de Publicação: 2016
Outros Autores: Ferreira, Nádia S., Truta, Liliana A. A. N. A., Sales, Goreti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/10046
Resumo: This work reports a novel way of producing an inexpensive substrate support to assemble a sensing film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle measurements and the conductive ink composition was optimized with regard to its adhesion, conductivity, and thermal stability. This support was further modified targeting its application in quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The recognition material consisted of an antibody-like receptor film for CRT, tailored on the support and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy analysis confirmed the presence of the polymeric film on the support, and the performance of the devices was extensively evaluated with regard to linear response ranges, selectivity, applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost and excellent reusability features. The design could also be extended to other applications in electricalbased approaches to be used in point-of-care (POC).
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spelling Conductive Paper with Antibody- Like Film for Electrical Readings of BiomoleculesThis work reports a novel way of producing an inexpensive substrate support to assemble a sensing film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle measurements and the conductive ink composition was optimized with regard to its adhesion, conductivity, and thermal stability. This support was further modified targeting its application in quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The recognition material consisted of an antibody-like receptor film for CRT, tailored on the support and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy analysis confirmed the presence of the polymeric film on the support, and the performance of the devices was extensively evaluated with regard to linear response ranges, selectivity, applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost and excellent reusability features. The design could also be extended to other applications in electricalbased approaches to be used in point-of-care (POC).Nature Publishing GroupRepositório Científico do Instituto Politécnico do PortoTavares, Ana P. M.Ferreira, Nádia S.Truta, Liliana A. A. N. A.Sales, Goreti2017-07-13T11:42:10Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/10046eng10.1038/srep26132info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:51:31ZPortal AgregadorONG
dc.title.none.fl_str_mv Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
title Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
spellingShingle Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
Tavares, Ana P. M.
title_short Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
title_full Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
title_fullStr Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
title_full_unstemmed Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
title_sort Conductive Paper with Antibody- Like Film for Electrical Readings of Biomolecules
author Tavares, Ana P. M.
author_facet Tavares, Ana P. M.
Ferreira, Nádia S.
Truta, Liliana A. A. N. A.
Sales, Goreti
author_role author
author2 Ferreira, Nádia S.
Truta, Liliana A. A. N. A.
Sales, Goreti
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Tavares, Ana P. M.
Ferreira, Nádia S.
Truta, Liliana A. A. N. A.
Sales, Goreti
description This work reports a novel way of producing an inexpensive substrate support to assemble a sensing film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle measurements and the conductive ink composition was optimized with regard to its adhesion, conductivity, and thermal stability. This support was further modified targeting its application in quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The recognition material consisted of an antibody-like receptor film for CRT, tailored on the support and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy analysis confirmed the presence of the polymeric film on the support, and the performance of the devices was extensively evaluated with regard to linear response ranges, selectivity, applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost and excellent reusability features. The design could also be extended to other applications in electricalbased approaches to be used in point-of-care (POC).
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2017-07-13T11:42:10Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/10046
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1038/srep26132
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dc.publisher.none.fl_str_mv Nature Publishing Group
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