CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?

Detalhes bibliográficos
Autor(a) principal: Bento, Tatiana
Data de Publicação: 2023
Outros Autores: Santos Miranda, Mariana, Landeiro, Raquel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.58043/rphrc.104
Resumo: Introduction: Thyroid pathology and cardiovascular disease (CVD) are very prevalent in the general population. Some studies demonstrate an association between thyroid dysfunction and CVD. Taking into account that CVD can increase the risk of events and mortality, it’s important to know modifiable risk factors and act on them. Objective: The aim of this study is to verify whether thyroid pathology is associated with CVD in the adult population. Material and Methods: Evidence-based review of systematic reviews (SR), meta-analyses (MA) and randomized clinical trials (RCT), in Portuguese and English, published in the last 10 years, in the PubMed database using the MeSH terms “cardiovascular diseases” and “thyroid diseases”. The Strength of Recommendation Taxonomy (SORT) Scale from the American Family Physician was used to assess the level of evidence and recommendation strength. Results: 99 articles were found of which 73 were excluded after reading the title, 12 after reading the abstract and 4 after reading the full article, being selected 10 for analysis (4 MA, 2 RS e 4 MA+RS). According to Smedegaard et al., subclinical hyperthyroidism can cause atrial fibrillation (AF) and heart failure (HF), Ding and Gong et al. mentioned an association with metabolic syndrome (increased risk of obesity, hypertension, high level of triglycerides and total and low-density cholesterol, low level of high-density lipoprotein), and Srisawat referred association between hyperthyroidism and venous thromboembolism. Huang mentioned that subclinical hypothyroidism is associated with AF, and Collet stated an association with coronary disease regardless the presence of antibodies. Floriani et al. reported than subclinical hypothyroidism with TSH ≥ 10 mlU/L and subclinical hyperthyroidism with TSH < 0,1 MlU/L increase the risk of mortality so should be treated. Kostopoulos et al. mentioned an association between differentiated thyroid carcinoma and a higher risk of developing AF. Conclusion: Most studies show an association between thyroid pathology and CVD, as AF and other arrhythmias, HF, increased CV risk and mortality. Therefore, some studies refer to the importance of tracking and treating dysfunction, even if it is subclinical. However, this association remains controversial and it’s important to carry out more studies and more robust ones.
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spelling CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?DOENÇA CARDIOVASCULAR PODERÁ SER CAUSADA POR PATOLOGIA DA TIROIDE?doença cardiovascularpatologia da tiroidehipotiroidismohipertiroidismocardiovascular diseasethyroid pathologyhypothyroidismhyperthyroidismIntroduction: Thyroid pathology and cardiovascular disease (CVD) are very prevalent in the general population. Some studies demonstrate an association between thyroid dysfunction and CVD. Taking into account that CVD can increase the risk of events and mortality, it’s important to know modifiable risk factors and act on them. Objective: The aim of this study is to verify whether thyroid pathology is associated with CVD in the adult population. Material and Methods: Evidence-based review of systematic reviews (SR), meta-analyses (MA) and randomized clinical trials (RCT), in Portuguese and English, published in the last 10 years, in the PubMed database using the MeSH terms “cardiovascular diseases” and “thyroid diseases”. The Strength of Recommendation Taxonomy (SORT) Scale from the American Family Physician was used to assess the level of evidence and recommendation strength. Results: 99 articles were found of which 73 were excluded after reading the title, 12 after reading the abstract and 4 after reading the full article, being selected 10 for analysis (4 MA, 2 RS e 4 MA+RS). According to Smedegaard et al., subclinical hyperthyroidism can cause atrial fibrillation (AF) and heart failure (HF), Ding and Gong et al. mentioned an association with metabolic syndrome (increased risk of obesity, hypertension, high level of triglycerides and total and low-density cholesterol, low level of high-density lipoprotein), and Srisawat referred association between hyperthyroidism and venous thromboembolism. Huang mentioned that subclinical hypothyroidism is associated with AF, and Collet stated an association with coronary disease regardless the presence of antibodies. Floriani et al. reported than subclinical hypothyroidism with TSH ≥ 10 mlU/L and subclinical hyperthyroidism with TSH < 0,1 MlU/L increase the risk of mortality so should be treated. Kostopoulos et al. mentioned an association between differentiated thyroid carcinoma and a higher risk of developing AF. Conclusion: Most studies show an association between thyroid pathology and CVD, as AF and other arrhythmias, HF, increased CV risk and mortality. Therefore, some studies refer to the importance of tracking and treating dysfunction, even if it is subclinical. However, this association remains controversial and it’s important to carry out more studies and more robust ones.Introdução: Patologia da tiroide e doença cardiovascular (DCV) são ambas muito prevalentes na população em geral. Alguns estudos demonstram associação entre disfunção tiroideia e DCV. Tendo em conta que a DCV pode aumentar o risco de eventos e mortalidade, é importante conhecer fatores de risco modificáveis e atuar nestes. Objetivo: Com este trabalho pretende verificar-se se patologia tiroideia se associa a DCV na população adulta. Material e Métodos: Revisão baseada na evidência de revisões sistemáticas (RS), metanálises (MA) e ensaios clínicos randomizados (RCT), nas línguas portuguesa e inglesa, publicados nos últimos 10 anos, na base de dados PubMed, utilizando os termos MeSH “cardiovascular diseases” e “thyroid diseases”. Para avaliação do nível de evidência e atribuição de força de recomendação foi utilizada a escala Strenght of Recommendation Taxonomy (SORT) da American Family Physician. Resultados: Foram encontrados 99 artigos, dos quais foram excluídos 73 após leitura do título, 12 após leitura do abstract e 4 após leitura integral, tendo sido selecionados 10 para análise (4 MA, 2 RS e 4 MA+RS). Segundo Smedegaard et al., hipertiroidismo subclínico pode causar fibrilhação auricular (FA) e insuficiência cardíaca (IC), Ding e Gong et al. mencionaram associação a síndrome metabólico (aumento do risco de obesidade, hipertensão, nível de triglicéridos, colesterol total e de lipoproteína de baixa densidade e baixo nível de lipoproteína de alta densidade), e Srisawat associação entre hipertiroidismo e tromboembolismo venoso. Huang referiu que hipotiroidismo subclínico se associa a FA, e Collet mencionou associação com doença coronária independente da presença de anticorpos. Floriani et al. referiu que hipotiroidismo subclínico com TSH≥10mlU/L e hipertiroidismo subclínico com TSH<0,1mlU/L aumentam o risco de mortalidade, pelo que devem ser tratados. Kostopoulos et al. referiu associação entre carcinoma diferenciado da tiroide e maior risco de desenvolver FA. Conclusão: A maioria dos estudos mostra associação entre patologia tiroideia e DCV, nomeadamente FA, outras arritmias e IC, aumento do risco CV e da mortalidade. Pelo que alguns estudos referem importância de rastrear e tratar disfunção, mesmo que subclínica. Contudo esta associação permanece controversa, sendo importante realizar mais estudos e mais robustos.Revista Portuguesa de Hipertensão e Risco Cardiovascular2023-10-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.58043/rphrc.104https://doi.org/10.58043/rphrc.104Revista Portuguesa de Hipertensão e Risco Cardiovascular; N.º 97 (2023): Setembro/Outubro; 26-301646-8287reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revistahipertensao.pt/index.php/rh/article/view/104https://revistahipertensao.pt/index.php/rh/article/view/104/91Direitos de Autor (c) 2023 Tatiana Bentoinfo:eu-repo/semantics/openAccessBento, TatianaSantos Miranda, MarianaLandeiro, Raquel2023-12-09T07:20:32Zoai:ojs.revistahipertensao.pt:article/104Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:39:17.503635Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
DOENÇA CARDIOVASCULAR PODERÁ SER CAUSADA POR PATOLOGIA DA TIROIDE?
title CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
spellingShingle CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
Bento, Tatiana
doença cardiovascular
patologia da tiroide
hipotiroidismo
hipertiroidismo
cardiovascular disease
thyroid pathology
hypothyroidism
hyperthyroidism
title_short CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
title_full CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
title_fullStr CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
title_full_unstemmed CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
title_sort CAN CARDIOVASCULAR DISEASE BE CAUSED BY THYROID PATHOLOGY?
author Bento, Tatiana
author_facet Bento, Tatiana
Santos Miranda, Mariana
Landeiro, Raquel
author_role author
author2 Santos Miranda, Mariana
Landeiro, Raquel
author2_role author
author
dc.contributor.author.fl_str_mv Bento, Tatiana
Santos Miranda, Mariana
Landeiro, Raquel
dc.subject.por.fl_str_mv doença cardiovascular
patologia da tiroide
hipotiroidismo
hipertiroidismo
cardiovascular disease
thyroid pathology
hypothyroidism
hyperthyroidism
topic doença cardiovascular
patologia da tiroide
hipotiroidismo
hipertiroidismo
cardiovascular disease
thyroid pathology
hypothyroidism
hyperthyroidism
description Introduction: Thyroid pathology and cardiovascular disease (CVD) are very prevalent in the general population. Some studies demonstrate an association between thyroid dysfunction and CVD. Taking into account that CVD can increase the risk of events and mortality, it’s important to know modifiable risk factors and act on them. Objective: The aim of this study is to verify whether thyroid pathology is associated with CVD in the adult population. Material and Methods: Evidence-based review of systematic reviews (SR), meta-analyses (MA) and randomized clinical trials (RCT), in Portuguese and English, published in the last 10 years, in the PubMed database using the MeSH terms “cardiovascular diseases” and “thyroid diseases”. The Strength of Recommendation Taxonomy (SORT) Scale from the American Family Physician was used to assess the level of evidence and recommendation strength. Results: 99 articles were found of which 73 were excluded after reading the title, 12 after reading the abstract and 4 after reading the full article, being selected 10 for analysis (4 MA, 2 RS e 4 MA+RS). According to Smedegaard et al., subclinical hyperthyroidism can cause atrial fibrillation (AF) and heart failure (HF), Ding and Gong et al. mentioned an association with metabolic syndrome (increased risk of obesity, hypertension, high level of triglycerides and total and low-density cholesterol, low level of high-density lipoprotein), and Srisawat referred association between hyperthyroidism and venous thromboembolism. Huang mentioned that subclinical hypothyroidism is associated with AF, and Collet stated an association with coronary disease regardless the presence of antibodies. Floriani et al. reported than subclinical hypothyroidism with TSH ≥ 10 mlU/L and subclinical hyperthyroidism with TSH < 0,1 MlU/L increase the risk of mortality so should be treated. Kostopoulos et al. mentioned an association between differentiated thyroid carcinoma and a higher risk of developing AF. Conclusion: Most studies show an association between thyroid pathology and CVD, as AF and other arrhythmias, HF, increased CV risk and mortality. Therefore, some studies refer to the importance of tracking and treating dysfunction, even if it is subclinical. However, this association remains controversial and it’s important to carry out more studies and more robust ones.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-19
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.58043/rphrc.104
https://doi.org/10.58043/rphrc.104
url https://doi.org/10.58043/rphrc.104
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language por
dc.relation.none.fl_str_mv https://revistahipertensao.pt/index.php/rh/article/view/104
https://revistahipertensao.pt/index.php/rh/article/view/104/91
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2023 Tatiana Bento
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2023 Tatiana Bento
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Revista Portuguesa de Hipertensão e Risco Cardiovascular
publisher.none.fl_str_mv Revista Portuguesa de Hipertensão e Risco Cardiovascular
dc.source.none.fl_str_mv Revista Portuguesa de Hipertensão e Risco Cardiovascular; N.º 97 (2023): Setembro/Outubro; 26-30
1646-8287
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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