Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2743 |
Resumo: | Background: We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted to a hospital ward, and calculate the prevalence of risk factors for hypoglycemia and diabetic complications. Methods: In this cross-sectional, multicentered study, the observational data was collected by physicians from patient's hospitalization to discharge/death. Statistical tests were 2-tailed considering 5% significance level. Results: There were 646 ward admissions due to hyperglycemic emergencies and 176 hypoglycemic episodes with a ratio hypoglycemia/hyperglycemia 0.27 for all DM patients. In T2DM patients the ratio was 0.38. These were mainly female (55.1%), functionally dependent (61.4%) and retired/disabled (73.1%). Median age was 75 years and median duration of disease 11 years. Half the patients were on insulin-based therapy and 30.1% on secretagogue-based therapy. Approximately 57% of patients needed occasional/full assistance to manage the disease. The most frequent risk factor for hypoglycemia was polypharmacy (85.0%). Hypoglycemia in the 12 months before admission was higher in insulin-based therapy patients (66.1%; p = 0.001). Conclusions: Hyperglycemic emergencies are the most frequent cause of hospitalization in Portugal, although severe hypoglycemic events represent a health and social problem in elderly/frail patients. There is still the need to optimize therapy in terms of the potential for hypoglycemia in this patient group and a review of anti-hyperglycemic agents to add on to insulin. |
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Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD studyDiabetesHypoglycemic episodesInpatientsBackground: We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted to a hospital ward, and calculate the prevalence of risk factors for hypoglycemia and diabetic complications. Methods: In this cross-sectional, multicentered study, the observational data was collected by physicians from patient's hospitalization to discharge/death. Statistical tests were 2-tailed considering 5% significance level. Results: There were 646 ward admissions due to hyperglycemic emergencies and 176 hypoglycemic episodes with a ratio hypoglycemia/hyperglycemia 0.27 for all DM patients. In T2DM patients the ratio was 0.38. These were mainly female (55.1%), functionally dependent (61.4%) and retired/disabled (73.1%). Median age was 75 years and median duration of disease 11 years. Half the patients were on insulin-based therapy and 30.1% on secretagogue-based therapy. Approximately 57% of patients needed occasional/full assistance to manage the disease. The most frequent risk factor for hypoglycemia was polypharmacy (85.0%). Hypoglycemia in the 12 months before admission was higher in insulin-based therapy patients (66.1%; p = 0.001). Conclusions: Hyperglycemic emergencies are the most frequent cause of hospitalization in Portugal, although severe hypoglycemic events represent a health and social problem in elderly/frail patients. There is still the need to optimize therapy in terms of the potential for hypoglycemia in this patient group and a review of anti-hyperglycemic agents to add on to insulin.This work was supported by Merck Sharp & Dohme (MSD) Portugal [MK0431–854]. The study was scientifically promoted by the Portuguese Society of Diabetology (Sociedade Portuguesa de Diabetologia), Portuguese Society of Endocrinology, Diabetes and Metabolism (Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo) and Portuguese Society of Internal Medicine (Sociedade Portuguesa de Medicina Interna).BioMed CentralRepositório Científico do Centro Hospitalar Universitário de Santo AntónioAlão, SílviaConceição, JoãoDores, JorgeSantos, LèlitaAraújo, FranciscoPape, EstevãoReis, MónicaChipepo, ÁrciaNascimento, EditeBaptista, AnaPires, VanessaMarques, CarlosLages, Adriana De SousaPelicano-Romano, Joãode Jesus, Paula M.2022-11-10T10:32:02Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2743engAlão S, Conceição J, Dores J, et al. Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study. Clin Diabetes Endocrinol. 2021;7(1):2. doi:10.1186/s40842-020-00114-32055-826010.1186/s40842-020-00114-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:02:09Zoai:repositorio.chporto.pt:10400.16/2743Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:55.904643Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
title |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
spellingShingle |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study Alão, Sílvia Diabetes Hypoglycemic episodes Inpatients |
title_short |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
title_full |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
title_fullStr |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
title_full_unstemmed |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
title_sort |
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study |
author |
Alão, Sílvia |
author_facet |
Alão, Sílvia Conceição, João Dores, Jorge Santos, Lèlita Araújo, Francisco Pape, Estevão Reis, Mónica Chipepo, Árcia Nascimento, Edite Baptista, Ana Pires, Vanessa Marques, Carlos Lages, Adriana De Sousa Pelicano-Romano, João de Jesus, Paula M. |
author_role |
author |
author2 |
Conceição, João Dores, Jorge Santos, Lèlita Araújo, Francisco Pape, Estevão Reis, Mónica Chipepo, Árcia Nascimento, Edite Baptista, Ana Pires, Vanessa Marques, Carlos Lages, Adriana De Sousa Pelicano-Romano, João de Jesus, Paula M. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Alão, Sílvia Conceição, João Dores, Jorge Santos, Lèlita Araújo, Francisco Pape, Estevão Reis, Mónica Chipepo, Árcia Nascimento, Edite Baptista, Ana Pires, Vanessa Marques, Carlos Lages, Adriana De Sousa Pelicano-Romano, João de Jesus, Paula M. |
dc.subject.por.fl_str_mv |
Diabetes Hypoglycemic episodes Inpatients |
topic |
Diabetes Hypoglycemic episodes Inpatients |
description |
Background: We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted to a hospital ward, and calculate the prevalence of risk factors for hypoglycemia and diabetic complications. Methods: In this cross-sectional, multicentered study, the observational data was collected by physicians from patient's hospitalization to discharge/death. Statistical tests were 2-tailed considering 5% significance level. Results: There were 646 ward admissions due to hyperglycemic emergencies and 176 hypoglycemic episodes with a ratio hypoglycemia/hyperglycemia 0.27 for all DM patients. In T2DM patients the ratio was 0.38. These were mainly female (55.1%), functionally dependent (61.4%) and retired/disabled (73.1%). Median age was 75 years and median duration of disease 11 years. Half the patients were on insulin-based therapy and 30.1% on secretagogue-based therapy. Approximately 57% of patients needed occasional/full assistance to manage the disease. The most frequent risk factor for hypoglycemia was polypharmacy (85.0%). Hypoglycemia in the 12 months before admission was higher in insulin-based therapy patients (66.1%; p = 0.001). Conclusions: Hyperglycemic emergencies are the most frequent cause of hospitalization in Portugal, although severe hypoglycemic events represent a health and social problem in elderly/frail patients. There is still the need to optimize therapy in terms of the potential for hypoglycemia in this patient group and a review of anti-hyperglycemic agents to add on to insulin. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-11-10T10:32:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2743 |
url |
http://hdl.handle.net/10400.16/2743 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alão S, Conceição J, Dores J, et al. Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study. Clin Diabetes Endocrinol. 2021;7(1):2. doi:10.1186/s40842-020-00114-3 2055-8260 10.1186/s40842-020-00114-3 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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