Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase.
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484 |
Resumo: | Total serum N-acetyl-beta-D-glucosaminidase (NAG), isoenzyme A (labile) and isoenzyme B (stable) activities were determined in euthyroid controls and in thyroid disease. In twenty hyperthyroid individuals total NAG (856.9 +/- 122,676 nmols/h/ml and isoenzyme A (490.3 +/- 93.592) as well as isoenzyme B (361.6 +/- 66,371), were higher than the levels in nineteen hypothyroid [total NAG = 533.105 +/- 97.927 (p less than 0.001); isoenzyme A = 280.263 +/- 61.463 (p less than 0.001); isoenzyme B = 251,580 +/- 50,530 (p less than 0.001)] or in twenty euthyroid [total NAG = 555.55 +/- 75.59 (p less than 0.001); isoenzyme A = 316.85 +/- 55.0 (p less than 0.001); isoenzyme B = 238.95 +/- 39.60 (p less than 0.001)]. Monthly assays were performed in seven hypothyroid and eleven hyperthyroid over the course of their corrective treatment with L-thyroxine (LT4: 0.1-0.2 mg (day) and propylthiouracil (PTU: 0.3-0.4/day), respectively. Total T4 was taken as the criterion for thyroid status. The reduction of hormone activity in seven hyperthyroid was accompanied by a significant decrease in enzyme activity (NAG = p less than 0.02; isoenzyme A = p less than 0.02). Isoenzyme B displayed no significant variation. In four hyperthyroid submitted to treatment with PTU there was no reduction in NAG activity and although T4 came down to normal levels. These patients still displayed symptoms of hyperthyroidism.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase.Relação das hormonas tiroideias com a actividade sérica total e específica da N-acetil-beta-D-glucosaminidase.Total serum N-acetyl-beta-D-glucosaminidase (NAG), isoenzyme A (labile) and isoenzyme B (stable) activities were determined in euthyroid controls and in thyroid disease. In twenty hyperthyroid individuals total NAG (856.9 +/- 122,676 nmols/h/ml and isoenzyme A (490.3 +/- 93.592) as well as isoenzyme B (361.6 +/- 66,371), were higher than the levels in nineteen hypothyroid [total NAG = 533.105 +/- 97.927 (p less than 0.001); isoenzyme A = 280.263 +/- 61.463 (p less than 0.001); isoenzyme B = 251,580 +/- 50,530 (p less than 0.001)] or in twenty euthyroid [total NAG = 555.55 +/- 75.59 (p less than 0.001); isoenzyme A = 316.85 +/- 55.0 (p less than 0.001); isoenzyme B = 238.95 +/- 39.60 (p less than 0.001)]. Monthly assays were performed in seven hypothyroid and eleven hyperthyroid over the course of their corrective treatment with L-thyroxine (LT4: 0.1-0.2 mg (day) and propylthiouracil (PTU: 0.3-0.4/day), respectively. Total T4 was taken as the criterion for thyroid status. The reduction of hormone activity in seven hyperthyroid was accompanied by a significant decrease in enzyme activity (NAG = p less than 0.02; isoenzyme A = p less than 0.02). Isoenzyme B displayed no significant variation. In four hyperthyroid submitted to treatment with PTU there was no reduction in NAG activity and although T4 came down to normal levels. These patients still displayed symptoms of hyperthyroidism.(ABSTRACT TRUNCATED AT 250 WORDS)Total serum N-acetyl-beta-D-glucosaminidase (NAG), isoenzyme A (labile) and isoenzyme B (stable) activities were determined in euthyroid controls and in thyroid disease. In twenty hyperthyroid individuals total NAG (856.9 +/- 122,676 nmols/h/ml and isoenzyme A (490.3 +/- 93.592) as well as isoenzyme B (361.6 +/- 66,371), were higher than the levels in nineteen hypothyroid [total NAG = 533.105 +/- 97.927 (p less than 0.001); isoenzyme A = 280.263 +/- 61.463 (p less than 0.001); isoenzyme B = 251,580 +/- 50,530 (p less than 0.001)] or in twenty euthyroid [total NAG = 555.55 +/- 75.59 (p less than 0.001); isoenzyme A = 316.85 +/- 55.0 (p less than 0.001); isoenzyme B = 238.95 +/- 39.60 (p less than 0.001)]. Monthly assays were performed in seven hypothyroid and eleven hyperthyroid over the course of their corrective treatment with L-thyroxine (LT4: 0.1-0.2 mg (day) and propylthiouracil (PTU: 0.3-0.4/day), respectively. Total T4 was taken as the criterion for thyroid status. The reduction of hormone activity in seven hyperthyroid was accompanied by a significant decrease in enzyme activity (NAG = p less than 0.02; isoenzyme A = p less than 0.02). Isoenzyme B displayed no significant variation. In four hyperthyroid submitted to treatment with PTU there was no reduction in NAG activity and although T4 came down to normal levels. These patients still displayed symptoms of hyperthyroidism.(ABSTRACT TRUNCATED AT 250 WORDS)Ordem dos Médicos1989-10-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484oai:ojs.www.actamedicaportuguesa.com:article/3484Acta Médica Portuguesa; Vol. 2 No. 4-5 (1989): Agosto-Outubro; 203-6Acta Médica Portuguesa; Vol. 2 N.º 4-5 (1989): Agosto-Outubro; 203-61646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484/2774Pinto, CGalvão-Teles, AMarques, CManso, Cinfo:eu-repo/semantics/openAccess2022-12-20T11:02:15ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. Relação das hormonas tiroideias com a actividade sérica total e específica da N-acetil-beta-D-glucosaminidase. |
title |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
spellingShingle |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. Pinto, C |
title_short |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
title_full |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
title_fullStr |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
title_full_unstemmed |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
title_sort |
Relation of thyroid hormones with the total and specific serum activity of N-acetyl-beta-D-glucosaminidase. |
author |
Pinto, C |
author_facet |
Pinto, C Galvão-Teles, A Marques, C Manso, C |
author_role |
author |
author2 |
Galvão-Teles, A Marques, C Manso, C |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pinto, C Galvão-Teles, A Marques, C Manso, C |
description |
Total serum N-acetyl-beta-D-glucosaminidase (NAG), isoenzyme A (labile) and isoenzyme B (stable) activities were determined in euthyroid controls and in thyroid disease. In twenty hyperthyroid individuals total NAG (856.9 +/- 122,676 nmols/h/ml and isoenzyme A (490.3 +/- 93.592) as well as isoenzyme B (361.6 +/- 66,371), were higher than the levels in nineteen hypothyroid [total NAG = 533.105 +/- 97.927 (p less than 0.001); isoenzyme A = 280.263 +/- 61.463 (p less than 0.001); isoenzyme B = 251,580 +/- 50,530 (p less than 0.001)] or in twenty euthyroid [total NAG = 555.55 +/- 75.59 (p less than 0.001); isoenzyme A = 316.85 +/- 55.0 (p less than 0.001); isoenzyme B = 238.95 +/- 39.60 (p less than 0.001)]. Monthly assays were performed in seven hypothyroid and eleven hyperthyroid over the course of their corrective treatment with L-thyroxine (LT4: 0.1-0.2 mg (day) and propylthiouracil (PTU: 0.3-0.4/day), respectively. Total T4 was taken as the criterion for thyroid status. The reduction of hormone activity in seven hyperthyroid was accompanied by a significant decrease in enzyme activity (NAG = p less than 0.02; isoenzyme A = p less than 0.02). Isoenzyme B displayed no significant variation. In four hyperthyroid submitted to treatment with PTU there was no reduction in NAG activity and although T4 came down to normal levels. These patients still displayed symptoms of hyperthyroidism.(ABSTRACT TRUNCATED AT 250 WORDS) |
publishDate |
1989 |
dc.date.none.fl_str_mv |
1989-10-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484 oai:ojs.www.actamedicaportuguesa.com:article/3484 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3484 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3484/2774 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 2 No. 4-5 (1989): Agosto-Outubro; 203-6 Acta Médica Portuguesa; Vol. 2 N.º 4-5 (1989): Agosto-Outubro; 203-6 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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repository.mail.fl_str_mv |
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1777301641227141120 |