Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.

Detalhes bibliográficos
Autor(a) principal: Santos, N
Data de Publicação: 2012
Outros Autores: Gaspar, A, Livramento, S, Sampaio, G, Morais-Almeida, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/6231
Resumo: Women with inherited thrombophilia and recurrent miscarriage might benefit from preconceptional antiagreggation with low-dose acetylsalicylic acid (ASA), but concerns about severe adverse reactions may prevent physicians from performing this treatment in patients with ASA hypersensitivity. We report the first known case of ASA desensitization in a 41-year-old woman with inherited thrombophilia, who had homozygosity (4G/4G polymorphism) of the plasminogen activator inhibitor-1 (PAI-1) gene and first trimester recurrent miscarriage, and had previously presented with anaphylaxis to ASA. Desensitization was completed despite one self-limited adverse reaction, and the patient has maintained a daily ASA intake of 100 mg with good tolerance.
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spelling Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.Abortion, HabitualAspirinDrug HypersensitivityDesensitization, ImmunologicHipersensibilidade a MedicamentosAspirinaAborto HabitualDessensibilização ImunológicaWomen with inherited thrombophilia and recurrent miscarriage might benefit from preconceptional antiagreggation with low-dose acetylsalicylic acid (ASA), but concerns about severe adverse reactions may prevent physicians from performing this treatment in patients with ASA hypersensitivity. We report the first known case of ASA desensitization in a 41-year-old woman with inherited thrombophilia, who had homozygosity (4G/4G polymorphism) of the plasminogen activator inhibitor-1 (PAI-1) gene and first trimester recurrent miscarriage, and had previously presented with anaphylaxis to ASA. Desensitization was completed despite one self-limited adverse reaction, and the patient has maintained a daily ASA intake of 100 mg with good tolerance.Repositório ComumSantos, NGaspar, ALivramento, SSampaio, GMorais-Almeida, M2014-04-20T17:06:30Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6231engEur Ann Allergy Clin Immunol. 2012;44(6):256-7.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:24:58Zoai:comum.rcaap.pt:10400.26/6231Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:22:38.216126Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
title Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
spellingShingle Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
Santos, N
Abortion, Habitual
Aspirin
Drug Hypersensitivity
Desensitization, Immunologic
Hipersensibilidade a Medicamentos
Aspirina
Aborto Habitual
Dessensibilização Imunológica
title_short Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
title_full Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
title_fullStr Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
title_full_unstemmed Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
title_sort Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage.
author Santos, N
author_facet Santos, N
Gaspar, A
Livramento, S
Sampaio, G
Morais-Almeida, M
author_role author
author2 Gaspar, A
Livramento, S
Sampaio, G
Morais-Almeida, M
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Santos, N
Gaspar, A
Livramento, S
Sampaio, G
Morais-Almeida, M
dc.subject.por.fl_str_mv Abortion, Habitual
Aspirin
Drug Hypersensitivity
Desensitization, Immunologic
Hipersensibilidade a Medicamentos
Aspirina
Aborto Habitual
Dessensibilização Imunológica
topic Abortion, Habitual
Aspirin
Drug Hypersensitivity
Desensitization, Immunologic
Hipersensibilidade a Medicamentos
Aspirina
Aborto Habitual
Dessensibilização Imunológica
description Women with inherited thrombophilia and recurrent miscarriage might benefit from preconceptional antiagreggation with low-dose acetylsalicylic acid (ASA), but concerns about severe adverse reactions may prevent physicians from performing this treatment in patients with ASA hypersensitivity. We report the first known case of ASA desensitization in a 41-year-old woman with inherited thrombophilia, who had homozygosity (4G/4G polymorphism) of the plasminogen activator inhibitor-1 (PAI-1) gene and first trimester recurrent miscarriage, and had previously presented with anaphylaxis to ASA. Desensitization was completed despite one self-limited adverse reaction, and the patient has maintained a daily ASA intake of 100 mg with good tolerance.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2014-04-20T17:06:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/6231
url http://hdl.handle.net/10400.26/6231
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur Ann Allergy Clin Immunol. 2012;44(6):256-7.
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dc.format.none.fl_str_mv application/pdf
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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