Classification of current anticancer immunotherapies
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48232 |
Resumo: | © 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Classification of current anticancer immunotherapiesAdoptive cell transferCheckpoint blockersDendritic cell-based interventionsDNA-based vaccinesImmunostimulatory cytokinesPeptide-based vaccinesOncolytic virusesToll-like receptor agonists© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.Impact Journals, LLCRepositório da Universidade de LisboaGalluzzi, LorenzoVacchelli, ErikaBravo-San Pedro, José-ManuelBuqué, AitziberSenovilla, LauraBaracco, Elisa ElenaBloy, NormaCastoldi, FrancescaAbastado, Jean-PierreAgostinis, PatriziaApte, Ron N.Aranda, FernandoAyyoub, MahaBeckhove, PhilippBlay, Jean-YvesBracci, LauraCaignard, AnneCastelli, ChiaraCavallo, FedericaCelis, EstabanCerundolo, VincenzoClayton, AledColombo, Mario P.Coussens, LisaDhodapkar, Madhav V.Eggermont, Alexander M.Fearon, Douglas T.Fridman, Wolf H.Fučíková, JitkaGabrilovich, Dmitry I.Galon, JérômeGarg, AbhishekGhiringhelli, FrançoisGiaccone, GiuseppeGilboa, EliGnjatic, SachaHoos, AxelHosmalin, AnneJäger, DirkKalinski, PawelKärre, KlasKepp, OliverKiessling, RolfKirkwood, John M.Klein, EvaKnuth, AlexanderLewis, Claire E.Liblau, RolandLotze, Michael T.Lugli, EnricoMach, Jean-PierreMattei, FabrizioMavilio, DomenicoMelero, IgnacioMelief, Cornelis J.Mittendorf, Elizabeth A.Moretta, LorenzoOdunsi, AdekunkeOkada, HidehoPalucka, Anna KarolinaPeter, Marcus E.Pienta, Kenneth J.Porgador, AngelPrendergast, George C.Rabinovich, Gabriel A.Restifo, Nicholas P.Rizvi, NaiyerSautès-Fridman, CatherineSchreiber, HansSeliger, BarbaraShiku, HiroshiSilva-Santos, BrunoSmyth, Mark J.Speiser, Daniel E.Spisek, RadekSrivastava, Pramod K.Talmadge, James E.Tartour, EricVan Der Burg, Sjoerd H.Van Den Eynde, Benoît J.Vile, RichardWagner, HermannWeber, Jeffrey SWhiteside, Theresa L.Wolchok, Jedd D.Zitvogel, LaurenceZou, WeipingKroemer, Guido2021-05-28T12:41:08Z2014-12-302014-12-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48232engOncotarget. 2014 Dec 30;5(24):12472-1250810.18632/oncotarget.29981949-2553info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:29Zoai:repositorio.ul.pt:10451/48232Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:07.870522Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Classification of current anticancer immunotherapies |
title |
Classification of current anticancer immunotherapies |
spellingShingle |
Classification of current anticancer immunotherapies Galluzzi, Lorenzo Adoptive cell transfer Checkpoint blockers Dendritic cell-based interventions DNA-based vaccines Immunostimulatory cytokines Peptide-based vaccines Oncolytic viruses Toll-like receptor agonists |
title_short |
Classification of current anticancer immunotherapies |
title_full |
Classification of current anticancer immunotherapies |
title_fullStr |
Classification of current anticancer immunotherapies |
title_full_unstemmed |
Classification of current anticancer immunotherapies |
title_sort |
Classification of current anticancer immunotherapies |
author |
Galluzzi, Lorenzo |
author_facet |
Galluzzi, Lorenzo Vacchelli, Erika Bravo-San Pedro, José-Manuel Buqué, Aitziber Senovilla, Laura Baracco, Elisa Elena Bloy, Norma Castoldi, Francesca Abastado, Jean-Pierre Agostinis, Patrizia Apte, Ron N. Aranda, Fernando Ayyoub, Maha Beckhove, Philipp Blay, Jean-Yves Bracci, Laura Caignard, Anne Castelli, Chiara Cavallo, Federica Celis, Estaban Cerundolo, Vincenzo Clayton, Aled Colombo, Mario P. Coussens, Lisa Dhodapkar, Madhav V. Eggermont, Alexander M. Fearon, Douglas T. Fridman, Wolf H. Fučíková, Jitka Gabrilovich, Dmitry I. Galon, Jérôme Garg, Abhishek Ghiringhelli, François Giaccone, Giuseppe Gilboa, Eli Gnjatic, Sacha Hoos, Axel Hosmalin, Anne Jäger, Dirk Kalinski, Pawel Kärre, Klas Kepp, Oliver Kiessling, Rolf Kirkwood, John M. Klein, Eva Knuth, Alexander Lewis, Claire E. Liblau, Roland Lotze, Michael T. Lugli, Enrico Mach, Jean-Pierre Mattei, Fabrizio Mavilio, Domenico Melero, Ignacio Melief, Cornelis J. Mittendorf, Elizabeth A. Moretta, Lorenzo Odunsi, Adekunke Okada, Hideho Palucka, Anna Karolina Peter, Marcus E. Pienta, Kenneth J. Porgador, Angel Prendergast, George C. Rabinovich, Gabriel A. Restifo, Nicholas P. Rizvi, Naiyer Sautès-Fridman, Catherine Schreiber, Hans Seliger, Barbara Shiku, Hiroshi Silva-Santos, Bruno Smyth, Mark J. Speiser, Daniel E. Spisek, Radek Srivastava, Pramod K. Talmadge, James E. Tartour, Eric Van Der Burg, Sjoerd H. Van Den Eynde, Benoît J. Vile, Richard Wagner, Hermann Weber, Jeffrey S Whiteside, Theresa L. Wolchok, Jedd D. Zitvogel, Laurence Zou, Weiping Kroemer, Guido |
author_role |
author |
author2 |
Vacchelli, Erika Bravo-San Pedro, José-Manuel Buqué, Aitziber Senovilla, Laura Baracco, Elisa Elena Bloy, Norma Castoldi, Francesca Abastado, Jean-Pierre Agostinis, Patrizia Apte, Ron N. Aranda, Fernando Ayyoub, Maha Beckhove, Philipp Blay, Jean-Yves Bracci, Laura Caignard, Anne Castelli, Chiara Cavallo, Federica Celis, Estaban Cerundolo, Vincenzo Clayton, Aled Colombo, Mario P. Coussens, Lisa Dhodapkar, Madhav V. Eggermont, Alexander M. Fearon, Douglas T. Fridman, Wolf H. Fučíková, Jitka Gabrilovich, Dmitry I. Galon, Jérôme Garg, Abhishek Ghiringhelli, François Giaccone, Giuseppe Gilboa, Eli Gnjatic, Sacha Hoos, Axel Hosmalin, Anne Jäger, Dirk Kalinski, Pawel Kärre, Klas Kepp, Oliver Kiessling, Rolf Kirkwood, John M. Klein, Eva Knuth, Alexander Lewis, Claire E. Liblau, Roland Lotze, Michael T. Lugli, Enrico Mach, Jean-Pierre Mattei, Fabrizio Mavilio, Domenico Melero, Ignacio Melief, Cornelis J. Mittendorf, Elizabeth A. Moretta, Lorenzo Odunsi, Adekunke Okada, Hideho Palucka, Anna Karolina Peter, Marcus E. Pienta, Kenneth J. Porgador, Angel Prendergast, George C. Rabinovich, Gabriel A. Restifo, Nicholas P. Rizvi, Naiyer Sautès-Fridman, Catherine Schreiber, Hans Seliger, Barbara Shiku, Hiroshi Silva-Santos, Bruno Smyth, Mark J. Speiser, Daniel E. Spisek, Radek Srivastava, Pramod K. Talmadge, James E. Tartour, Eric Van Der Burg, Sjoerd H. Van Den Eynde, Benoît J. Vile, Richard Wagner, Hermann Weber, Jeffrey S Whiteside, Theresa L. Wolchok, Jedd D. Zitvogel, Laurence Zou, Weiping Kroemer, Guido |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Galluzzi, Lorenzo Vacchelli, Erika Bravo-San Pedro, José-Manuel Buqué, Aitziber Senovilla, Laura Baracco, Elisa Elena Bloy, Norma Castoldi, Francesca Abastado, Jean-Pierre Agostinis, Patrizia Apte, Ron N. Aranda, Fernando Ayyoub, Maha Beckhove, Philipp Blay, Jean-Yves Bracci, Laura Caignard, Anne Castelli, Chiara Cavallo, Federica Celis, Estaban Cerundolo, Vincenzo Clayton, Aled Colombo, Mario P. Coussens, Lisa Dhodapkar, Madhav V. Eggermont, Alexander M. Fearon, Douglas T. Fridman, Wolf H. Fučíková, Jitka Gabrilovich, Dmitry I. Galon, Jérôme Garg, Abhishek Ghiringhelli, François Giaccone, Giuseppe Gilboa, Eli Gnjatic, Sacha Hoos, Axel Hosmalin, Anne Jäger, Dirk Kalinski, Pawel Kärre, Klas Kepp, Oliver Kiessling, Rolf Kirkwood, John M. Klein, Eva Knuth, Alexander Lewis, Claire E. Liblau, Roland Lotze, Michael T. Lugli, Enrico Mach, Jean-Pierre Mattei, Fabrizio Mavilio, Domenico Melero, Ignacio Melief, Cornelis J. Mittendorf, Elizabeth A. Moretta, Lorenzo Odunsi, Adekunke Okada, Hideho Palucka, Anna Karolina Peter, Marcus E. Pienta, Kenneth J. Porgador, Angel Prendergast, George C. Rabinovich, Gabriel A. Restifo, Nicholas P. Rizvi, Naiyer Sautès-Fridman, Catherine Schreiber, Hans Seliger, Barbara Shiku, Hiroshi Silva-Santos, Bruno Smyth, Mark J. Speiser, Daniel E. Spisek, Radek Srivastava, Pramod K. Talmadge, James E. Tartour, Eric Van Der Burg, Sjoerd H. Van Den Eynde, Benoît J. Vile, Richard Wagner, Hermann Weber, Jeffrey S Whiteside, Theresa L. Wolchok, Jedd D. Zitvogel, Laurence Zou, Weiping Kroemer, Guido |
dc.subject.por.fl_str_mv |
Adoptive cell transfer Checkpoint blockers Dendritic cell-based interventions DNA-based vaccines Immunostimulatory cytokines Peptide-based vaccines Oncolytic viruses Toll-like receptor agonists |
topic |
Adoptive cell transfer Checkpoint blockers Dendritic cell-based interventions DNA-based vaccines Immunostimulatory cytokines Peptide-based vaccines Oncolytic viruses Toll-like receptor agonists |
description |
© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-30 2014-12-30T00:00:00Z 2021-05-28T12:41:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48232 |
url |
http://hdl.handle.net/10451/48232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oncotarget. 2014 Dec 30;5(24):12472-12508 10.18632/oncotarget.2998 1949-2553 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Impact Journals, LLC |
publisher.none.fl_str_mv |
Impact Journals, LLC |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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