Classification of current anticancer immunotherapies

Detalhes bibliográficos
Autor(a) principal: Galluzzi, Lorenzo
Data de Publicação: 2014
Outros Autores: Vacchelli, Erika, Bravo-San Pedro, José-Manuel, Buqué, Aitziber, Senovilla, Laura, Baracco, Elisa Elena, Bloy, Norma, Castoldi, Francesca, Abastado, Jean-Pierre, Agostinis, Patrizia, Apte, Ron N., Aranda, Fernando, Ayyoub, Maha, Beckhove, Philipp, Blay, Jean-Yves, Bracci, Laura, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Estaban, Cerundolo, Vincenzo, Clayton, Aled, Colombo, Mario P., Coussens, Lisa, Dhodapkar, Madhav V., Eggermont, Alexander M., Fearon, Douglas T., Fridman, Wolf H., Fučíková, Jitka, Gabrilovich, Dmitry I., Galon, Jérôme, Garg, Abhishek, Ghiringhelli, François, Giaccone, Giuseppe, Gilboa, Eli, Gnjatic, Sacha, Hoos, Axel, Hosmalin, Anne, Jäger, Dirk, Kalinski, Pawel, Kärre, Klas, Kepp, Oliver, Kiessling, Rolf, Kirkwood, John M., Klein, Eva, Knuth, Alexander, Lewis, Claire E., Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Mach, Jean-Pierre, Mattei, Fabrizio, Mavilio, Domenico, Melero, Ignacio, Melief, Cornelis J., Mittendorf, Elizabeth A., Moretta, Lorenzo, Odunsi, Adekunke, Okada, Hideho, Palucka, Anna Karolina, Peter, Marcus E., Pienta, Kenneth J., Porgador, Angel, Prendergast, George C., Rabinovich, Gabriel A., Restifo, Nicholas P., Rizvi, Naiyer, Sautès-Fridman, Catherine, Schreiber, Hans, Seliger, Barbara, Shiku, Hiroshi, Silva-Santos, Bruno, Smyth, Mark J., Speiser, Daniel E., Spisek, Radek, Srivastava, Pramod K., Talmadge, James E., Tartour, Eric, Van Der Burg, Sjoerd H., Van Den Eynde, Benoît J., Vile, Richard, Wagner, Hermann, Weber, Jeffrey S, Whiteside, Theresa L., Wolchok, Jedd D., Zitvogel, Laurence, Zou, Weiping, Kroemer, Guido
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48232
Resumo: © 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
id RCAP_66cba8cc3a3b7105cee3b6c56af61ffd
oai_identifier_str oai:repositorio.ul.pt:10451/48232
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Classification of current anticancer immunotherapiesAdoptive cell transferCheckpoint blockersDendritic cell-based interventionsDNA-based vaccinesImmunostimulatory cytokinesPeptide-based vaccinesOncolytic virusesToll-like receptor agonists© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.Impact Journals, LLCRepositório da Universidade de LisboaGalluzzi, LorenzoVacchelli, ErikaBravo-San Pedro, José-ManuelBuqué, AitziberSenovilla, LauraBaracco, Elisa ElenaBloy, NormaCastoldi, FrancescaAbastado, Jean-PierreAgostinis, PatriziaApte, Ron N.Aranda, FernandoAyyoub, MahaBeckhove, PhilippBlay, Jean-YvesBracci, LauraCaignard, AnneCastelli, ChiaraCavallo, FedericaCelis, EstabanCerundolo, VincenzoClayton, AledColombo, Mario P.Coussens, LisaDhodapkar, Madhav V.Eggermont, Alexander M.Fearon, Douglas T.Fridman, Wolf H.Fučíková, JitkaGabrilovich, Dmitry I.Galon, JérômeGarg, AbhishekGhiringhelli, FrançoisGiaccone, GiuseppeGilboa, EliGnjatic, SachaHoos, AxelHosmalin, AnneJäger, DirkKalinski, PawelKärre, KlasKepp, OliverKiessling, RolfKirkwood, John M.Klein, EvaKnuth, AlexanderLewis, Claire E.Liblau, RolandLotze, Michael T.Lugli, EnricoMach, Jean-PierreMattei, FabrizioMavilio, DomenicoMelero, IgnacioMelief, Cornelis J.Mittendorf, Elizabeth A.Moretta, LorenzoOdunsi, AdekunkeOkada, HidehoPalucka, Anna KarolinaPeter, Marcus E.Pienta, Kenneth J.Porgador, AngelPrendergast, George C.Rabinovich, Gabriel A.Restifo, Nicholas P.Rizvi, NaiyerSautès-Fridman, CatherineSchreiber, HansSeliger, BarbaraShiku, HiroshiSilva-Santos, BrunoSmyth, Mark J.Speiser, Daniel E.Spisek, RadekSrivastava, Pramod K.Talmadge, James E.Tartour, EricVan Der Burg, Sjoerd H.Van Den Eynde, Benoît J.Vile, RichardWagner, HermannWeber, Jeffrey SWhiteside, Theresa L.Wolchok, Jedd D.Zitvogel, LaurenceZou, WeipingKroemer, Guido2021-05-28T12:41:08Z2014-12-302014-12-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48232engOncotarget. 2014 Dec 30;5(24):12472-1250810.18632/oncotarget.29981949-2553info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:29Zoai:repositorio.ul.pt:10451/48232Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:07.870522Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Classification of current anticancer immunotherapies
title Classification of current anticancer immunotherapies
spellingShingle Classification of current anticancer immunotherapies
Galluzzi, Lorenzo
Adoptive cell transfer
Checkpoint blockers
Dendritic cell-based interventions
DNA-based vaccines
Immunostimulatory cytokines
Peptide-based vaccines
Oncolytic viruses
Toll-like receptor agonists
title_short Classification of current anticancer immunotherapies
title_full Classification of current anticancer immunotherapies
title_fullStr Classification of current anticancer immunotherapies
title_full_unstemmed Classification of current anticancer immunotherapies
title_sort Classification of current anticancer immunotherapies
author Galluzzi, Lorenzo
author_facet Galluzzi, Lorenzo
Vacchelli, Erika
Bravo-San Pedro, José-Manuel
Buqué, Aitziber
Senovilla, Laura
Baracco, Elisa Elena
Bloy, Norma
Castoldi, Francesca
Abastado, Jean-Pierre
Agostinis, Patrizia
Apte, Ron N.
Aranda, Fernando
Ayyoub, Maha
Beckhove, Philipp
Blay, Jean-Yves
Bracci, Laura
Caignard, Anne
Castelli, Chiara
Cavallo, Federica
Celis, Estaban
Cerundolo, Vincenzo
Clayton, Aled
Colombo, Mario P.
Coussens, Lisa
Dhodapkar, Madhav V.
Eggermont, Alexander M.
Fearon, Douglas T.
Fridman, Wolf H.
Fučíková, Jitka
Gabrilovich, Dmitry I.
Galon, Jérôme
Garg, Abhishek
Ghiringhelli, François
Giaccone, Giuseppe
Gilboa, Eli
Gnjatic, Sacha
Hoos, Axel
Hosmalin, Anne
Jäger, Dirk
Kalinski, Pawel
Kärre, Klas
Kepp, Oliver
Kiessling, Rolf
Kirkwood, John M.
Klein, Eva
Knuth, Alexander
Lewis, Claire E.
Liblau, Roland
Lotze, Michael T.
Lugli, Enrico
Mach, Jean-Pierre
Mattei, Fabrizio
Mavilio, Domenico
Melero, Ignacio
Melief, Cornelis J.
Mittendorf, Elizabeth A.
Moretta, Lorenzo
Odunsi, Adekunke
Okada, Hideho
Palucka, Anna Karolina
Peter, Marcus E.
Pienta, Kenneth J.
Porgador, Angel
Prendergast, George C.
Rabinovich, Gabriel A.
Restifo, Nicholas P.
Rizvi, Naiyer
Sautès-Fridman, Catherine
Schreiber, Hans
Seliger, Barbara
Shiku, Hiroshi
Silva-Santos, Bruno
Smyth, Mark J.
Speiser, Daniel E.
Spisek, Radek
Srivastava, Pramod K.
Talmadge, James E.
Tartour, Eric
Van Der Burg, Sjoerd H.
Van Den Eynde, Benoît J.
Vile, Richard
Wagner, Hermann
Weber, Jeffrey S
Whiteside, Theresa L.
Wolchok, Jedd D.
Zitvogel, Laurence
Zou, Weiping
Kroemer, Guido
author_role author
author2 Vacchelli, Erika
Bravo-San Pedro, José-Manuel
Buqué, Aitziber
Senovilla, Laura
Baracco, Elisa Elena
Bloy, Norma
Castoldi, Francesca
Abastado, Jean-Pierre
Agostinis, Patrizia
Apte, Ron N.
Aranda, Fernando
Ayyoub, Maha
Beckhove, Philipp
Blay, Jean-Yves
Bracci, Laura
Caignard, Anne
Castelli, Chiara
Cavallo, Federica
Celis, Estaban
Cerundolo, Vincenzo
Clayton, Aled
Colombo, Mario P.
Coussens, Lisa
Dhodapkar, Madhav V.
Eggermont, Alexander M.
Fearon, Douglas T.
Fridman, Wolf H.
Fučíková, Jitka
Gabrilovich, Dmitry I.
Galon, Jérôme
Garg, Abhishek
Ghiringhelli, François
Giaccone, Giuseppe
Gilboa, Eli
Gnjatic, Sacha
Hoos, Axel
Hosmalin, Anne
Jäger, Dirk
Kalinski, Pawel
Kärre, Klas
Kepp, Oliver
Kiessling, Rolf
Kirkwood, John M.
Klein, Eva
Knuth, Alexander
Lewis, Claire E.
Liblau, Roland
Lotze, Michael T.
Lugli, Enrico
Mach, Jean-Pierre
Mattei, Fabrizio
Mavilio, Domenico
Melero, Ignacio
Melief, Cornelis J.
Mittendorf, Elizabeth A.
Moretta, Lorenzo
Odunsi, Adekunke
Okada, Hideho
Palucka, Anna Karolina
Peter, Marcus E.
Pienta, Kenneth J.
Porgador, Angel
Prendergast, George C.
Rabinovich, Gabriel A.
Restifo, Nicholas P.
Rizvi, Naiyer
Sautès-Fridman, Catherine
Schreiber, Hans
Seliger, Barbara
Shiku, Hiroshi
Silva-Santos, Bruno
Smyth, Mark J.
Speiser, Daniel E.
Spisek, Radek
Srivastava, Pramod K.
Talmadge, James E.
Tartour, Eric
Van Der Burg, Sjoerd H.
Van Den Eynde, Benoît J.
Vile, Richard
Wagner, Hermann
Weber, Jeffrey S
Whiteside, Theresa L.
Wolchok, Jedd D.
Zitvogel, Laurence
Zou, Weiping
Kroemer, Guido
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Galluzzi, Lorenzo
Vacchelli, Erika
Bravo-San Pedro, José-Manuel
Buqué, Aitziber
Senovilla, Laura
Baracco, Elisa Elena
Bloy, Norma
Castoldi, Francesca
Abastado, Jean-Pierre
Agostinis, Patrizia
Apte, Ron N.
Aranda, Fernando
Ayyoub, Maha
Beckhove, Philipp
Blay, Jean-Yves
Bracci, Laura
Caignard, Anne
Castelli, Chiara
Cavallo, Federica
Celis, Estaban
Cerundolo, Vincenzo
Clayton, Aled
Colombo, Mario P.
Coussens, Lisa
Dhodapkar, Madhav V.
Eggermont, Alexander M.
Fearon, Douglas T.
Fridman, Wolf H.
Fučíková, Jitka
Gabrilovich, Dmitry I.
Galon, Jérôme
Garg, Abhishek
Ghiringhelli, François
Giaccone, Giuseppe
Gilboa, Eli
Gnjatic, Sacha
Hoos, Axel
Hosmalin, Anne
Jäger, Dirk
Kalinski, Pawel
Kärre, Klas
Kepp, Oliver
Kiessling, Rolf
Kirkwood, John M.
Klein, Eva
Knuth, Alexander
Lewis, Claire E.
Liblau, Roland
Lotze, Michael T.
Lugli, Enrico
Mach, Jean-Pierre
Mattei, Fabrizio
Mavilio, Domenico
Melero, Ignacio
Melief, Cornelis J.
Mittendorf, Elizabeth A.
Moretta, Lorenzo
Odunsi, Adekunke
Okada, Hideho
Palucka, Anna Karolina
Peter, Marcus E.
Pienta, Kenneth J.
Porgador, Angel
Prendergast, George C.
Rabinovich, Gabriel A.
Restifo, Nicholas P.
Rizvi, Naiyer
Sautès-Fridman, Catherine
Schreiber, Hans
Seliger, Barbara
Shiku, Hiroshi
Silva-Santos, Bruno
Smyth, Mark J.
Speiser, Daniel E.
Spisek, Radek
Srivastava, Pramod K.
Talmadge, James E.
Tartour, Eric
Van Der Burg, Sjoerd H.
Van Den Eynde, Benoît J.
Vile, Richard
Wagner, Hermann
Weber, Jeffrey S
Whiteside, Theresa L.
Wolchok, Jedd D.
Zitvogel, Laurence
Zou, Weiping
Kroemer, Guido
dc.subject.por.fl_str_mv Adoptive cell transfer
Checkpoint blockers
Dendritic cell-based interventions
DNA-based vaccines
Immunostimulatory cytokines
Peptide-based vaccines
Oncolytic viruses
Toll-like receptor agonists
topic Adoptive cell transfer
Checkpoint blockers
Dendritic cell-based interventions
DNA-based vaccines
Immunostimulatory cytokines
Peptide-based vaccines
Oncolytic viruses
Toll-like receptor agonists
description © 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-30
2014-12-30T00:00:00Z
2021-05-28T12:41:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48232
url http://hdl.handle.net/10451/48232
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oncotarget. 2014 Dec 30;5(24):12472-12508
10.18632/oncotarget.2998
1949-2553
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Impact Journals, LLC
publisher.none.fl_str_mv Impact Journals, LLC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134547936280576