Organizing pneumonia and COVID-19 : a report of two cases

Bibliographic Details
Main Author: Simões, Joana Paiva
Publication Date: 2021
Other Authors: Alves Ferreira, Ana Rita, Almeida, Pedro Martins, Trigueiros, Frederico, Braz, Armando, Inácio, João Rodrigues, Medeiros, Fábio, Braz, Sandra, Pais de Lacerda, António
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10451/46250
Summary: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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spelling Organizing pneumonia and COVID-19 : a report of two casesElsevierCOVID-19SARS-CoV-2CoronavirusOrganizing pneumoniaCorticosteroidsPortugal© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.Organizing pneumonia (OP) is a sub-acute process of pulmonary tissue repair secondary to lung injury, defined histopathologically by intra-alveolar buds of granulation tissue within the lumen of distal pulmonary airspaces. It can be either cryptogenic or secondary (SOP) to different clinical conditions, namely infections. Despite being nonspecific, its diagnosis can be made by the association of clinical and imaging criteria. We report two cases of OP associated to SARS-CoV-2 pneumonia, admitted at a Portuguese tertiary hospital unit dedicated to COVID-19. Both patients presented with severe respiratory failure with need of invasive mechanical ventilation. After initial recovery, there was worsening of dyspnea and hypoxemic respiratory failure with increase in inflammatory markers. Chest CT revealed an OP pattern. Other conditions such as superinfection, auto-immune disease and iatrogenic etiology, were excluded and corticotherapy at a dose of 1 mg/kg/day was administered. Chest CT follow up of both our patients showed complete resolution of OP pattern, with mild to moderate residual pulmonary fibrosis without honeycombing. There is no OP to SARS-CoV-2 case series yet published describing the progress of patients after corticotherapy, although the association between systemic corticosteroids and lower all-cause mortality in patients with COVID-19 has been recently established. It is possible that, as has been described with other viruses, OP secondary to SARS-CoV-2 represents an immunological process after initial infection, presenting with elevation of inflammatory markers and cytokines storm in the bloodstream and lung tissue, which may explain the favorable response to corticosteroids.ElsevierRepositório da Universidade de LisboaSimões, Joana PaivaAlves Ferreira, Ana RitaAlmeida, Pedro MartinsTrigueiros, FredericoBraz, ArmandoInácio, João RodriguesMedeiros, FábioBraz, SandraPais de Lacerda, António2021-02-09T17:05:55Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46250engRespir Med Case Rep. 2021;32:10135910.1016/j.rmcr.2021.1013592213-0071info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:27Zoai:repositorio.ul.pt:10451/46250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:29.138411Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Organizing pneumonia and COVID-19 : a report of two cases
Elsevier
title Organizing pneumonia and COVID-19 : a report of two cases
spellingShingle Organizing pneumonia and COVID-19 : a report of two cases
Simões, Joana Paiva
COVID-19
SARS-CoV-2
Coronavirus
Organizing pneumonia
Corticosteroids
Portugal
title_short Organizing pneumonia and COVID-19 : a report of two cases
title_full Organizing pneumonia and COVID-19 : a report of two cases
title_fullStr Organizing pneumonia and COVID-19 : a report of two cases
title_full_unstemmed Organizing pneumonia and COVID-19 : a report of two cases
title_sort Organizing pneumonia and COVID-19 : a report of two cases
author Simões, Joana Paiva
author_facet Simões, Joana Paiva
Alves Ferreira, Ana Rita
Almeida, Pedro Martins
Trigueiros, Frederico
Braz, Armando
Inácio, João Rodrigues
Medeiros, Fábio
Braz, Sandra
Pais de Lacerda, António
author_role author
author2 Alves Ferreira, Ana Rita
Almeida, Pedro Martins
Trigueiros, Frederico
Braz, Armando
Inácio, João Rodrigues
Medeiros, Fábio
Braz, Sandra
Pais de Lacerda, António
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Simões, Joana Paiva
Alves Ferreira, Ana Rita
Almeida, Pedro Martins
Trigueiros, Frederico
Braz, Armando
Inácio, João Rodrigues
Medeiros, Fábio
Braz, Sandra
Pais de Lacerda, António
dc.subject.por.fl_str_mv COVID-19
SARS-CoV-2
Coronavirus
Organizing pneumonia
Corticosteroids
Portugal
topic COVID-19
SARS-CoV-2
Coronavirus
Organizing pneumonia
Corticosteroids
Portugal
description © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-09T17:05:55Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46250
url http://hdl.handle.net/10451/46250
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respir Med Case Rep. 2021;32:101359
10.1016/j.rmcr.2021.101359
2213-0071
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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