TSH anti-receptor antibodies in Graves' disease.

Detalhes bibliográficos
Autor(a) principal: Sérgio, M R
Data de Publicação: 1996
Outros Autores: Godinho, C, Guerra, L, Agapito, A, Fonseca, F, Costa, C
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603
Resumo: The purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. TRAb was tested by an isotopic receptor assay-TRAK Henning-in 80 newly diagnosed, untreated Graves disease patients (group I), 63 with other thyroid diseases (group II) and 60 controls (group III). In group I, 11 patients were TRAb negative and 7 were considered in the gray area (TRAb between 9 and 14 U/L). In group II, only 2 patients had TRAb 9 U/l and all controls were TRAb negative. For statistical analysis patients with TRAb in gray area were excluded. Sensitivity and specificity for this assay were 84.5 and 100% respectively. Predictive value of 100% affords certainty that a hyperthyroid patient with a positive TRAb has Graves disease, not sequining a scintigram.
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spelling TSH anti-receptor antibodies in Graves' disease.Anticorpos anti-receptor da TSH na doença de Graves.The purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. TRAb was tested by an isotopic receptor assay-TRAK Henning-in 80 newly diagnosed, untreated Graves disease patients (group I), 63 with other thyroid diseases (group II) and 60 controls (group III). In group I, 11 patients were TRAb negative and 7 were considered in the gray area (TRAb between 9 and 14 U/L). In group II, only 2 patients had TRAb 9 U/l and all controls were TRAb negative. For statistical analysis patients with TRAb in gray area were excluded. Sensitivity and specificity for this assay were 84.5 and 100% respectively. Predictive value of 100% affords certainty that a hyperthyroid patient with a positive TRAb has Graves disease, not sequining a scintigram.The purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. TRAb was tested by an isotopic receptor assay-TRAK Henning-in 80 newly diagnosed, untreated Graves disease patients (group I), 63 with other thyroid diseases (group II) and 60 controls (group III). In group I, 11 patients were TRAb negative and 7 were considered in the gray area (TRAb between 9 and 14 U/L). In group II, only 2 patients had TRAb 9 U/l and all controls were TRAb negative. For statistical analysis patients with TRAb in gray area were excluded. Sensitivity and specificity for this assay were 84.5 and 100% respectively. Predictive value of 100% affords certainty that a hyperthyroid patient with a positive TRAb has Graves disease, not sequining a scintigram.Ordem dos Médicos1996-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603oai:ojs.www.actamedicaportuguesa.com:article/2603Acta Médica Portuguesa; Vol. 9 No. 7-9 (1996): Julho-Setembro; 229-31Acta Médica Portuguesa; Vol. 9 N.º 7-9 (1996): Julho-Setembro; 229-311646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603/2015Sérgio, M RGodinho, CGuerra, LAgapito, AFonseca, FCosta, Cinfo:eu-repo/semantics/openAccess2022-12-20T11:00:49ZPortal AgregadorONG
dc.title.none.fl_str_mv TSH anti-receptor antibodies in Graves' disease.
Anticorpos anti-receptor da TSH na doença de Graves.
title TSH anti-receptor antibodies in Graves' disease.
spellingShingle TSH anti-receptor antibodies in Graves' disease.
Sérgio, M R
title_short TSH anti-receptor antibodies in Graves' disease.
title_full TSH anti-receptor antibodies in Graves' disease.
title_fullStr TSH anti-receptor antibodies in Graves' disease.
title_full_unstemmed TSH anti-receptor antibodies in Graves' disease.
title_sort TSH anti-receptor antibodies in Graves' disease.
author Sérgio, M R
author_facet Sérgio, M R
Godinho, C
Guerra, L
Agapito, A
Fonseca, F
Costa, C
author_role author
author2 Godinho, C
Guerra, L
Agapito, A
Fonseca, F
Costa, C
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sérgio, M R
Godinho, C
Guerra, L
Agapito, A
Fonseca, F
Costa, C
description The purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. TRAb was tested by an isotopic receptor assay-TRAK Henning-in 80 newly diagnosed, untreated Graves disease patients (group I), 63 with other thyroid diseases (group II) and 60 controls (group III). In group I, 11 patients were TRAb negative and 7 were considered in the gray area (TRAb between 9 and 14 U/L). In group II, only 2 patients had TRAb 9 U/l and all controls were TRAb negative. For statistical analysis patients with TRAb in gray area were excluded. Sensitivity and specificity for this assay were 84.5 and 100% respectively. Predictive value of 100% affords certainty that a hyperthyroid patient with a positive TRAb has Graves disease, not sequining a scintigram.
publishDate 1996
dc.date.none.fl_str_mv 1996-09-30
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603
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url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/2603
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2603/2015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 9 No. 7-9 (1996): Julho-Setembro; 229-31
Acta Médica Portuguesa; Vol. 9 N.º 7-9 (1996): Julho-Setembro; 229-31
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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