Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/18669 |
Resumo: | Leaf fractions of Garcinia brasiliensis were evaluated concerning their antioxidant, antimicrobial, anti inflammatory and cytotoxic properties, and the most active fraction was then fully characterized regarding its phenolic composition using HPLC-DAD-ESI/MSn. The ethyl acetate fraction from partitioning of the methanolic leaf extract revealed a strong antioxidant activity that was comparable to Trolox, the positive control. This fraction was also able to show a significant antimicrobial activity against Gram-positive and Gram-negative bacteria and the fungus Candida albicans. However, the dichloromethane fraction was found to present the highest anti-inflammatory (83 ± 9 µg mL−1) and cytotoxic activities, thus presenting slight toxicity using a non-tumor cell line. Regarding the phenolic profile, the ethyl acetate fraction presented twelve flavonoids, with morelloflavone-7’’-O-glucoside (52.1 ± 0.4 mg g−1) and gardinia biflavonoid 2a glucoside (27.5 ± 0.2 mg g−1) being the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications. |
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Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, BrazilLeaf fractions of Garcinia brasiliensis were evaluated concerning their antioxidant, antimicrobial, anti inflammatory and cytotoxic properties, and the most active fraction was then fully characterized regarding its phenolic composition using HPLC-DAD-ESI/MSn. The ethyl acetate fraction from partitioning of the methanolic leaf extract revealed a strong antioxidant activity that was comparable to Trolox, the positive control. This fraction was also able to show a significant antimicrobial activity against Gram-positive and Gram-negative bacteria and the fungus Candida albicans. However, the dichloromethane fraction was found to present the highest anti-inflammatory (83 ± 9 µg mL−1) and cytotoxic activities, thus presenting slight toxicity using a non-tumor cell line. Regarding the phenolic profile, the ethyl acetate fraction presented twelve flavonoids, with morelloflavone-7’’-O-glucoside (52.1 ± 0.4 mg g−1) and gardinia biflavonoid 2a glucoside (27.5 ± 0.2 mg g−1) being the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros’s contract; to the FEDER-Interreg España- Portugal programme for financial support through the project 0377_Iberphenol_6_E.Biblioteca Digital do IPBZan, Renato AndréFernandes, ÂngelaJedoz, StephanieOludemi, TaofiqCalhelha, Ricardo C.Pires, Tânia C.S.Alves, Maria JoséMartins, Roberto Carlos CamposBarros, LillianFerreira, Isabel C.F.R.2018-01-19T10:00:00Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/18669engZan, Renato André; Fernandes, Ângela; Jedoz, Stephanie; Oludemi, Taofiq; Calhelha, Ricardo C.; Pires, Tânia C.S.P.; Alves, Maria José; Martins, Roberto Carlos Campos; Barros, Lillian; Ferreira, Isabel C.F.R. (2018) - Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil. Food and Function. ISSN 2042-6496. 9, p. 5621-56282042-649610.1039/c8fo01474dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:42:52Zoai:bibliotecadigital.ipb.pt:10198/18669Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:09:03.059968Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
title |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
spellingShingle |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil Zan, Renato André |
title_short |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
title_full |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
title_fullStr |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
title_full_unstemmed |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
title_sort |
Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil |
author |
Zan, Renato André |
author_facet |
Zan, Renato André Fernandes, Ângela Jedoz, Stephanie Oludemi, Taofiq Calhelha, Ricardo C. Pires, Tânia C.S. Alves, Maria José Martins, Roberto Carlos Campos Barros, Lillian Ferreira, Isabel C.F.R. |
author_role |
author |
author2 |
Fernandes, Ângela Jedoz, Stephanie Oludemi, Taofiq Calhelha, Ricardo C. Pires, Tânia C.S. Alves, Maria José Martins, Roberto Carlos Campos Barros, Lillian Ferreira, Isabel C.F.R. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Zan, Renato André Fernandes, Ângela Jedoz, Stephanie Oludemi, Taofiq Calhelha, Ricardo C. Pires, Tânia C.S. Alves, Maria José Martins, Roberto Carlos Campos Barros, Lillian Ferreira, Isabel C.F.R. |
description |
Leaf fractions of Garcinia brasiliensis were evaluated concerning their antioxidant, antimicrobial, anti inflammatory and cytotoxic properties, and the most active fraction was then fully characterized regarding its phenolic composition using HPLC-DAD-ESI/MSn. The ethyl acetate fraction from partitioning of the methanolic leaf extract revealed a strong antioxidant activity that was comparable to Trolox, the positive control. This fraction was also able to show a significant antimicrobial activity against Gram-positive and Gram-negative bacteria and the fungus Candida albicans. However, the dichloromethane fraction was found to present the highest anti-inflammatory (83 ± 9 µg mL−1) and cytotoxic activities, thus presenting slight toxicity using a non-tumor cell line. Regarding the phenolic profile, the ethyl acetate fraction presented twelve flavonoids, with morelloflavone-7’’-O-glucoside (52.1 ± 0.4 mg g−1) and gardinia biflavonoid 2a glucoside (27.5 ± 0.2 mg g−1) being the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/18669 |
url |
http://hdl.handle.net/10198/18669 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Zan, Renato André; Fernandes, Ângela; Jedoz, Stephanie; Oludemi, Taofiq; Calhelha, Ricardo C.; Pires, Tânia C.S.P.; Alves, Maria José; Martins, Roberto Carlos Campos; Barros, Lillian; Ferreira, Isabel C.F.R. (2018) - Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil. Food and Function. ISSN 2042-6496. 9, p. 5621-5628 2042-6496 10.1039/c8fo01474d |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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