Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/24342 |
Resumo: | Cherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the phenolic profile, in vitro antioxidant and tyrosinase inhibitory potential, and in vivo diuretic activity of 70% hydroethanolic cherry stems extract and cherry stems decoction (CSD). LC-DAD-ESI/MSn analysis revealed the presence of flavonoid-type compounds as main constituents for both preparations, especially flavanones (naringenin glycosides). Antioxidant activity evaluated through DPPH, ABTS, and FRAP methods was superior for cherry stems extract, probably due to the presence of phenolic-derived compounds in higher amounts than CSD. On the other hand, tyrosinase inhibitory potential and diuretic effect exerted by CSD were stronger, highlighting that other types of hydrophilic secondary metabolites are responsible for this bioactivity. Overall, our findings indicate that CS preparations could be used as promising mild diuretic agents and encourage further investigations regarding the correlation between their chemical composition and bioactive potential. |
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Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipitesby-productsCerasus sp.cherry stemsdiuretic activitypolyphenolsCherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the phenolic profile, in vitro antioxidant and tyrosinase inhibitory potential, and in vivo diuretic activity of 70% hydroethanolic cherry stems extract and cherry stems decoction (CSD). LC-DAD-ESI/MSn analysis revealed the presence of flavonoid-type compounds as main constituents for both preparations, especially flavanones (naringenin glycosides). Antioxidant activity evaluated through DPPH, ABTS, and FRAP methods was superior for cherry stems extract, probably due to the presence of phenolic-derived compounds in higher amounts than CSD. On the other hand, tyrosinase inhibitory potential and diuretic effect exerted by CSD were stronger, highlighting that other types of hydrophilic secondary metabolites are responsible for this bioactivity. Overall, our findings indicate that CS preparations could be used as promising mild diuretic agents and encourage further investigations regarding the correlation between their chemical composition and bioactive potential.This work was supported by a Grant of the Romanian Ministry of Education and Research, CCCDI—UEFISCDI, project number PN-III-P2-2.1-PED-2019-5360, within PNCDI III.” The authors MID, LB, and ICFRF are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and FCT/MCTES (PIDDAC); national funding by F.C.T. and P.I., through the institutional scientific employment program-contract for MID and LB contracts. To FEDER-Interreg Es-paña- Portugal programme for financial support through the project TRANSCoLAB 0612_TRANS_CO_LAB_2_P.Biblioteca Digital do IPBBabotă, MihaiVoştinaru, OliviuPăltinean, RamonaMihali, CosminDias, Maria InêsBarros, LillianFerreira, Isabel C.F.R.Mocan, AndreiCrişan, OvidiuNicula, CristinaCrişan, Gianina2018-01-19T10:00:00Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/24342engBabotă, Mihai; Voştinaru, Oliviu; Păltinean, Ramona; Mihali, Cosmin; Dias, Maria Inês; Barros, Lillian; Ferreira, Isabel C.F.R.; Mocan, Andrei; Crişan, Ovidiu; Nicula, Cristina; Crişan, Gianina (2021). Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites. Frontiers in Pharmacology. ISSN 1663-9812. 12, p. 1-1110.3389/fphar.2021.647947info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:54:27Zoai:bibliotecadigital.ipb.pt:10198/24342Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:15:11.613940Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
title |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
spellingShingle |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites Babotă, Mihai by-products Cerasus sp. cherry stems diuretic activity polyphenols |
title_short |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
title_full |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
title_fullStr |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
title_full_unstemmed |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
title_sort |
Chemical composition, diuretic, and antityrosinase activity of traditionally used romanian cerasorum stipites |
author |
Babotă, Mihai |
author_facet |
Babotă, Mihai Voştinaru, Oliviu Păltinean, Ramona Mihali, Cosmin Dias, Maria Inês Barros, Lillian Ferreira, Isabel C.F.R. Mocan, Andrei Crişan, Ovidiu Nicula, Cristina Crişan, Gianina |
author_role |
author |
author2 |
Voştinaru, Oliviu Păltinean, Ramona Mihali, Cosmin Dias, Maria Inês Barros, Lillian Ferreira, Isabel C.F.R. Mocan, Andrei Crişan, Ovidiu Nicula, Cristina Crişan, Gianina |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Babotă, Mihai Voştinaru, Oliviu Păltinean, Ramona Mihali, Cosmin Dias, Maria Inês Barros, Lillian Ferreira, Isabel C.F.R. Mocan, Andrei Crişan, Ovidiu Nicula, Cristina Crişan, Gianina |
dc.subject.por.fl_str_mv |
by-products Cerasus sp. cherry stems diuretic activity polyphenols |
topic |
by-products Cerasus sp. cherry stems diuretic activity polyphenols |
description |
Cherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the phenolic profile, in vitro antioxidant and tyrosinase inhibitory potential, and in vivo diuretic activity of 70% hydroethanolic cherry stems extract and cherry stems decoction (CSD). LC-DAD-ESI/MSn analysis revealed the presence of flavonoid-type compounds as main constituents for both preparations, especially flavanones (naringenin glycosides). Antioxidant activity evaluated through DPPH, ABTS, and FRAP methods was superior for cherry stems extract, probably due to the presence of phenolic-derived compounds in higher amounts than CSD. On the other hand, tyrosinase inhibitory potential and diuretic effect exerted by CSD were stronger, highlighting that other types of hydrophilic secondary metabolites are responsible for this bioactivity. Overall, our findings indicate that CS preparations could be used as promising mild diuretic agents and encourage further investigations regarding the correlation between their chemical composition and bioactive potential. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/24342 |
url |
http://hdl.handle.net/10198/24342 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Babotă, Mihai; Voştinaru, Oliviu; Păltinean, Ramona; Mihali, Cosmin; Dias, Maria Inês; Barros, Lillian; Ferreira, Isabel C.F.R.; Mocan, Andrei; Crişan, Ovidiu; Nicula, Cristina; Crişan, Gianina (2021). Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites. Frontiers in Pharmacology. ISSN 1663-9812. 12, p. 1-11 10.3389/fphar.2021.647947 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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