Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Armanda Viana
Data de Publicação: 2022
Outros Autores: Valerio-Bolas, Ana, Alexandre-Pires, Graça, Aires Pereira, Maria, Nunes, Telmo, Ligeiro, Dario, Pereira da Fonseca, Isabel, Santos-Gomes, Gabriela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24309
Resumo: Research Areas: Life Sciences & Biomedicine
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spelling Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasitesBlood macrophagesKupffer cellsInnate immunityLeishmania infantumZoonotic visceral leishmaniasisResearch Areas: Life Sciences & BiomedicineL. infantum is the aetiological agent of zoonotic visceral leishmaniasis (ZVL), a disease that affects humans and dogs. Leishmania parasites are well adapted to aggressive conditions inside the phagolysosome and can control the immune activation of macrophages (MØs). Although MØs are highly active phagocytic cells with the capacity to destroy pathogens, they additionally comprise the host cells for Leishmania infection, replication, and stable establishment in the mammal host. The present study compares, for the first time, the innate immune response to L. infantum infection of two different macrophage lineages: the blood macrophages and the liver macrophages (Kupffer cells, KC). Our findings showed that L. infantum takes advantage of the natural predisposition of blood-MØs to phagocyte pathogens. However, parasites rapidly subvert the mechanisms of MØs immune activation. On the other hand, KCs, which are primed for immune tolerance, are not extensively activated and can overcome the dormancy induced by the parasite, exhibiting a selection of immune mechanisms, such as extracellular trap formation. Altogether, KCs reveal a different pattern of response in contrast with blood-MØs when confronting L. infantum parasites. In addition, KCs response appears to be more efficient in managing parasite infection, thus contributing to the ability of the liver to naturally restrain Leishmania disseminationMDPIRepositório da Universidade de LisboaRodrigues, Armanda VianaValerio-Bolas, AnaAlexandre-Pires, GraçaAires Pereira, MariaNunes, TelmoLigeiro, DarioPereira da Fonseca, IsabelSantos-Gomes, Gabriela2022-05-14T22:34:33Z2022-01-092022-01-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24309engRodrigues AV, Valério-Bolas A, Alexandre-Pires G, Aires Pereira M, Nunes T, Ligeiro D, Pereira da Fonseca I, Santos-Gomes G. 2022. Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites. Biology, 11(1):100. DOI 10.3390/biology1101010010.3390/biology110101002079-7737info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:58Zoai:www.repository.utl.pt:10400.5/24309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:23.444330Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
title Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
spellingShingle Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
Rodrigues, Armanda Viana
Blood macrophages
Kupffer cells
Innate immunity
Leishmania infantum
Zoonotic visceral leishmaniasis
title_short Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
title_full Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
title_fullStr Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
title_full_unstemmed Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
title_sort Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
author Rodrigues, Armanda Viana
author_facet Rodrigues, Armanda Viana
Valerio-Bolas, Ana
Alexandre-Pires, Graça
Aires Pereira, Maria
Nunes, Telmo
Ligeiro, Dario
Pereira da Fonseca, Isabel
Santos-Gomes, Gabriela
author_role author
author2 Valerio-Bolas, Ana
Alexandre-Pires, Graça
Aires Pereira, Maria
Nunes, Telmo
Ligeiro, Dario
Pereira da Fonseca, Isabel
Santos-Gomes, Gabriela
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Armanda Viana
Valerio-Bolas, Ana
Alexandre-Pires, Graça
Aires Pereira, Maria
Nunes, Telmo
Ligeiro, Dario
Pereira da Fonseca, Isabel
Santos-Gomes, Gabriela
dc.subject.por.fl_str_mv Blood macrophages
Kupffer cells
Innate immunity
Leishmania infantum
Zoonotic visceral leishmaniasis
topic Blood macrophages
Kupffer cells
Innate immunity
Leishmania infantum
Zoonotic visceral leishmaniasis
description Research Areas: Life Sciences & Biomedicine
publishDate 2022
dc.date.none.fl_str_mv 2022-05-14T22:34:33Z
2022-01-09
2022-01-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24309
url http://hdl.handle.net/10400.5/24309
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues AV, Valério-Bolas A, Alexandre-Pires G, Aires Pereira M, Nunes T, Ligeiro D, Pereira da Fonseca I, Santos-Gomes G. 2022. Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites. Biology, 11(1):100. DOI 10.3390/biology11010100
10.3390/biology11010100
2079-7737
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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