Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50785 |
Resumo: | © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs =-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs =-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.This study was funded by a Memorabel grant from Deltaplan Dementie (The Netherlands Organisation for Health Research and Development, and Alzheimer Nederland grant number 7330598105), National Institutes of Health (Grants AG010124, AG032953, AG043503, NS088341, AG017586, AG052943, AG038490), the Wyncote Foundation, Dana Foundation, Brightfocus Foundation, Penn Institute on Aging, Pla estratègic de recerca i innovació en salut 2016-2020, Catalan Department of Health (grant number SLT002/16/00408), Italian Ministry of Health (Ricerca Corrente) and the German Federal Ministry of Education and Research (FTLDc 01GI1007A). MS was supported by the Else Kröner-Fresenius-Stiftung. CW was supported by the Vaillant StiftungBMJ Publishing Group Ltd.Repositório da Universidade de LisboaMeeter, Lieke H. H.Steketee, Rebecca M. E.Salkovic, DinaVos, Maartje E.Grossman, MurrayMcMillan, Corey T.Irwin, David J.Boxer, Adam L.Rojas, Julio C.Olney, Nicholas T.Karydas, AnnaMiller, Bruce L.Pijnenburg, Yolande A. L.Barkhof, FrederikSánchez-Valle, RaquelLladó, AlbertBorrego-Ecija, SergiDiehl-Schmid, JanineGrimmer, TimoGoldhardt, OliverSantillo, Alexander F.Hansson, OskarVestberg, SusanneBorroni, BarbaraPadovani, AlessandroGalimberti, DanielaScarpini, ElioRohrer, Jonathan D.Woollacott, Ione O. C.Synofzik, MatthisWilke, CarloDe Mendonça, AlexandreVandenberghe, RikBenussi, LuisaGhidoni, RobertaBinetti, GiulianoNiessen, Wiro J.Papma, Janne M.Seelaar, HarroJiskoot, Lize C.de Jong, Frank JanDonker Kaat, LauraDel Campo, MartaTeunissen, Charlotte E.Bron, Esther E.Van den Berg, EstherVan Swieten, John C.2022-01-12T14:59:21Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50785engJ Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-10040022-305010.1136/jnnp-2018-3197841468-330Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:08Zoai:repositorio.ul.pt:10451/50785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:10.389838Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
title |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
spellingShingle |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia Meeter, Lieke H. H. |
title_short |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
title_full |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
title_fullStr |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
title_full_unstemmed |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
title_sort |
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia |
author |
Meeter, Lieke H. H. |
author_facet |
Meeter, Lieke H. H. Steketee, Rebecca M. E. Salkovic, Dina Vos, Maartje E. Grossman, Murray McMillan, Corey T. Irwin, David J. Boxer, Adam L. Rojas, Julio C. Olney, Nicholas T. Karydas, Anna Miller, Bruce L. Pijnenburg, Yolande A. L. Barkhof, Frederik Sánchez-Valle, Raquel Lladó, Albert Borrego-Ecija, Sergi Diehl-Schmid, Janine Grimmer, Timo Goldhardt, Oliver Santillo, Alexander F. Hansson, Oskar Vestberg, Susanne Borroni, Barbara Padovani, Alessandro Galimberti, Daniela Scarpini, Elio Rohrer, Jonathan D. Woollacott, Ione O. C. Synofzik, Matthis Wilke, Carlo De Mendonça, Alexandre Vandenberghe, Rik Benussi, Luisa Ghidoni, Roberta Binetti, Giuliano Niessen, Wiro J. Papma, Janne M. Seelaar, Harro Jiskoot, Lize C. de Jong, Frank Jan Donker Kaat, Laura Del Campo, Marta Teunissen, Charlotte E. Bron, Esther E. Van den Berg, Esther Van Swieten, John C. |
author_role |
author |
author2 |
Steketee, Rebecca M. E. Salkovic, Dina Vos, Maartje E. Grossman, Murray McMillan, Corey T. Irwin, David J. Boxer, Adam L. Rojas, Julio C. Olney, Nicholas T. Karydas, Anna Miller, Bruce L. Pijnenburg, Yolande A. L. Barkhof, Frederik Sánchez-Valle, Raquel Lladó, Albert Borrego-Ecija, Sergi Diehl-Schmid, Janine Grimmer, Timo Goldhardt, Oliver Santillo, Alexander F. Hansson, Oskar Vestberg, Susanne Borroni, Barbara Padovani, Alessandro Galimberti, Daniela Scarpini, Elio Rohrer, Jonathan D. Woollacott, Ione O. C. Synofzik, Matthis Wilke, Carlo De Mendonça, Alexandre Vandenberghe, Rik Benussi, Luisa Ghidoni, Roberta Binetti, Giuliano Niessen, Wiro J. Papma, Janne M. Seelaar, Harro Jiskoot, Lize C. de Jong, Frank Jan Donker Kaat, Laura Del Campo, Marta Teunissen, Charlotte E. Bron, Esther E. Van den Berg, Esther Van Swieten, John C. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Meeter, Lieke H. H. Steketee, Rebecca M. E. Salkovic, Dina Vos, Maartje E. Grossman, Murray McMillan, Corey T. Irwin, David J. Boxer, Adam L. Rojas, Julio C. Olney, Nicholas T. Karydas, Anna Miller, Bruce L. Pijnenburg, Yolande A. L. Barkhof, Frederik Sánchez-Valle, Raquel Lladó, Albert Borrego-Ecija, Sergi Diehl-Schmid, Janine Grimmer, Timo Goldhardt, Oliver Santillo, Alexander F. Hansson, Oskar Vestberg, Susanne Borroni, Barbara Padovani, Alessandro Galimberti, Daniela Scarpini, Elio Rohrer, Jonathan D. Woollacott, Ione O. C. Synofzik, Matthis Wilke, Carlo De Mendonça, Alexandre Vandenberghe, Rik Benussi, Luisa Ghidoni, Roberta Binetti, Giuliano Niessen, Wiro J. Papma, Janne M. Seelaar, Harro Jiskoot, Lize C. de Jong, Frank Jan Donker Kaat, Laura Del Campo, Marta Teunissen, Charlotte E. Bron, Esther E. Van den Berg, Esther Van Swieten, John C. |
description |
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2022-01-12T14:59:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50785 |
url |
http://hdl.handle.net/10451/50785 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-1004 0022-3050 10.1136/jnnp-2018-319784 1468-330X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group Ltd. |
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BMJ Publishing Group Ltd. |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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