Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

Detalhes bibliográficos
Autor(a) principal: Meeter, Lieke H. H.
Data de Publicação: 2019
Outros Autores: Steketee, Rebecca M. E., Salkovic, Dina, Vos, Maartje E., Grossman, Murray, McMillan, Corey T., Irwin, David J., Boxer, Adam L., Rojas, Julio C., Olney, Nicholas T., Karydas, Anna, Miller, Bruce L., Pijnenburg, Yolande A. L., Barkhof, Frederik, Sánchez-Valle, Raquel, Lladó, Albert, Borrego-Ecija, Sergi, Diehl-Schmid, Janine, Grimmer, Timo, Goldhardt, Oliver, Santillo, Alexander F., Hansson, Oskar, Vestberg, Susanne, Borroni, Barbara, Padovani, Alessandro, Galimberti, Daniela, Scarpini, Elio, Rohrer, Jonathan D., Woollacott, Ione O. C., Synofzik, Matthis, Wilke, Carlo, De Mendonça, Alexandre, Vandenberghe, Rik, Benussi, Luisa, Ghidoni, Roberta, Binetti, Giuliano, Niessen, Wiro J., Papma, Janne M., Seelaar, Harro, Jiskoot, Lize C., de Jong, Frank Jan, Donker Kaat, Laura, Del Campo, Marta, Teunissen, Charlotte E., Bron, Esther E., Van den Berg, Esther, Van Swieten, John C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50785
Resumo: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
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spelling Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs =-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs =-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.This study was funded by a Memorabel grant from Deltaplan Dementie (The Netherlands Organisation for Health Research and Development, and Alzheimer Nederland grant number 7330598105), National Institutes of Health (Grants AG010124, AG032953, AG043503, NS088341, AG017586, AG052943, AG038490), the Wyncote Foundation, Dana Foundation, Brightfocus Foundation, Penn Institute on Aging, Pla estratègic de recerca i innovació en salut 2016-2020, Catalan Department of Health (grant number SLT002/16/00408), Italian Ministry of Health (Ricerca Corrente) and the German Federal Ministry of Education and Research (FTLDc 01GI1007A). MS was supported by the Else Kröner-Fresenius-Stiftung. CW was supported by the Vaillant StiftungBMJ Publishing Group Ltd.Repositório da Universidade de LisboaMeeter, Lieke H. H.Steketee, Rebecca M. E.Salkovic, DinaVos, Maartje E.Grossman, MurrayMcMillan, Corey T.Irwin, David J.Boxer, Adam L.Rojas, Julio C.Olney, Nicholas T.Karydas, AnnaMiller, Bruce L.Pijnenburg, Yolande A. L.Barkhof, FrederikSánchez-Valle, RaquelLladó, AlbertBorrego-Ecija, SergiDiehl-Schmid, JanineGrimmer, TimoGoldhardt, OliverSantillo, Alexander F.Hansson, OskarVestberg, SusanneBorroni, BarbaraPadovani, AlessandroGalimberti, DanielaScarpini, ElioRohrer, Jonathan D.Woollacott, Ione O. C.Synofzik, MatthisWilke, CarloDe Mendonça, AlexandreVandenberghe, RikBenussi, LuisaGhidoni, RobertaBinetti, GiulianoNiessen, Wiro J.Papma, Janne M.Seelaar, HarroJiskoot, Lize C.de Jong, Frank JanDonker Kaat, LauraDel Campo, MartaTeunissen, Charlotte E.Bron, Esther E.Van den Berg, EstherVan Swieten, John C.2022-01-12T14:59:21Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50785engJ Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-10040022-305010.1136/jnnp-2018-3197841468-330Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:08Zoai:repositorio.ul.pt:10451/50785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:10.389838Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
title Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
spellingShingle Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
Meeter, Lieke H. H.
title_short Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
title_full Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
title_fullStr Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
title_full_unstemmed Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
title_sort Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
author Meeter, Lieke H. H.
author_facet Meeter, Lieke H. H.
Steketee, Rebecca M. E.
Salkovic, Dina
Vos, Maartje E.
Grossman, Murray
McMillan, Corey T.
Irwin, David J.
Boxer, Adam L.
Rojas, Julio C.
Olney, Nicholas T.
Karydas, Anna
Miller, Bruce L.
Pijnenburg, Yolande A. L.
Barkhof, Frederik
Sánchez-Valle, Raquel
Lladó, Albert
Borrego-Ecija, Sergi
Diehl-Schmid, Janine
Grimmer, Timo
Goldhardt, Oliver
Santillo, Alexander F.
Hansson, Oskar
Vestberg, Susanne
Borroni, Barbara
Padovani, Alessandro
Galimberti, Daniela
Scarpini, Elio
Rohrer, Jonathan D.
Woollacott, Ione O. C.
Synofzik, Matthis
Wilke, Carlo
De Mendonça, Alexandre
Vandenberghe, Rik
Benussi, Luisa
Ghidoni, Roberta
Binetti, Giuliano
Niessen, Wiro J.
Papma, Janne M.
Seelaar, Harro
Jiskoot, Lize C.
de Jong, Frank Jan
Donker Kaat, Laura
Del Campo, Marta
Teunissen, Charlotte E.
Bron, Esther E.
Van den Berg, Esther
Van Swieten, John C.
author_role author
author2 Steketee, Rebecca M. E.
Salkovic, Dina
Vos, Maartje E.
Grossman, Murray
McMillan, Corey T.
Irwin, David J.
Boxer, Adam L.
Rojas, Julio C.
Olney, Nicholas T.
Karydas, Anna
Miller, Bruce L.
Pijnenburg, Yolande A. L.
Barkhof, Frederik
Sánchez-Valle, Raquel
Lladó, Albert
Borrego-Ecija, Sergi
Diehl-Schmid, Janine
Grimmer, Timo
Goldhardt, Oliver
Santillo, Alexander F.
Hansson, Oskar
Vestberg, Susanne
Borroni, Barbara
Padovani, Alessandro
Galimberti, Daniela
Scarpini, Elio
Rohrer, Jonathan D.
Woollacott, Ione O. C.
Synofzik, Matthis
Wilke, Carlo
De Mendonça, Alexandre
Vandenberghe, Rik
Benussi, Luisa
Ghidoni, Roberta
Binetti, Giuliano
Niessen, Wiro J.
Papma, Janne M.
Seelaar, Harro
Jiskoot, Lize C.
de Jong, Frank Jan
Donker Kaat, Laura
Del Campo, Marta
Teunissen, Charlotte E.
Bron, Esther E.
Van den Berg, Esther
Van Swieten, John C.
author2_role author
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author
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Meeter, Lieke H. H.
Steketee, Rebecca M. E.
Salkovic, Dina
Vos, Maartje E.
Grossman, Murray
McMillan, Corey T.
Irwin, David J.
Boxer, Adam L.
Rojas, Julio C.
Olney, Nicholas T.
Karydas, Anna
Miller, Bruce L.
Pijnenburg, Yolande A. L.
Barkhof, Frederik
Sánchez-Valle, Raquel
Lladó, Albert
Borrego-Ecija, Sergi
Diehl-Schmid, Janine
Grimmer, Timo
Goldhardt, Oliver
Santillo, Alexander F.
Hansson, Oskar
Vestberg, Susanne
Borroni, Barbara
Padovani, Alessandro
Galimberti, Daniela
Scarpini, Elio
Rohrer, Jonathan D.
Woollacott, Ione O. C.
Synofzik, Matthis
Wilke, Carlo
De Mendonça, Alexandre
Vandenberghe, Rik
Benussi, Luisa
Ghidoni, Roberta
Binetti, Giuliano
Niessen, Wiro J.
Papma, Janne M.
Seelaar, Harro
Jiskoot, Lize C.
de Jong, Frank Jan
Donker Kaat, Laura
Del Campo, Marta
Teunissen, Charlotte E.
Bron, Esther E.
Van den Berg, Esther
Van Swieten, John C.
description © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-01-12T14:59:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50785
url http://hdl.handle.net/10451/50785
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-1004
0022-3050
10.1136/jnnp-2018-319784
1468-330X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group Ltd.
publisher.none.fl_str_mv BMJ Publishing Group Ltd.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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