Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions
Main Author: | |
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Publication Date: | 2010 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/1822/29358 |
Summary: | Thyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the value of LVD in benign and malignant thyroid lesions, we analyzed 110 thyroidectomy specimens using D2-40, a specific marker for lymphatic vessels and vascular endothelial growth factor C (VEGF-C), the most potent molecule of lymphatic proliferation. LVD was significantly different between papillary and follicular carcinomas in total (p = 0.045) and peritumoral area (p = 0.042). Follicular adenoma and follicular carcinoma showed an important difference of intra- (p = 0.019) and peritumoral (p = 0.033) LVD. VEGF-C was more markedly expressed in malignancies than in benign lesions (p = 0.0001). Almost all cancers with high positive VEGF-C expression also exhibited increased peritumoral LVD (p = 0.049) when compared with the benign lesions. Indeed, the high peritumoral LVD of malignant thyroid lesions is an important finding for surgery planning and supports the practice of total thyroidectomy in malignant thyroid neoplasm's since the lymphatic peritumoral vessels definitely are an escape path for tumor cells. |
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Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesionsLymphatic vessel densityVEGF-CThyroidThyroid cancerVascular endothelial growth factorTumor lymphangiogenesisScience & TechnologyThyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the value of LVD in benign and malignant thyroid lesions, we analyzed 110 thyroidectomy specimens using D2-40, a specific marker for lymphatic vessels and vascular endothelial growth factor C (VEGF-C), the most potent molecule of lymphatic proliferation. LVD was significantly different between papillary and follicular carcinomas in total (p = 0.045) and peritumoral area (p = 0.042). Follicular adenoma and follicular carcinoma showed an important difference of intra- (p = 0.019) and peritumoral (p = 0.033) LVD. VEGF-C was more markedly expressed in malignancies than in benign lesions (p = 0.0001). Almost all cancers with high positive VEGF-C expression also exhibited increased peritumoral LVD (p = 0.049) when compared with the benign lesions. Indeed, the high peritumoral LVD of malignant thyroid lesions is an important finding for surgery planning and supports the practice of total thyroidectomy in malignant thyroid neoplasm's since the lymphatic peritumoral vessels definitely are an escape path for tumor cells.Humana PressUniversidade do MinhoGarcia, Eduardo AnselmoSimões, KleberWakamatsu, AldaRessio, Rodrigo AlbergariaAlves, Venâncio Avancini FerreiraLongatto Filho, AdhemarCamargo, Roberto Souza20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29358eng1046-397610.1007/s12022-010-9116-920336393http://link.springer.com/article/10.1007%2Fs12022-010-9116-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:18Zoai:repositorium.sdum.uminho.pt:1822/29358Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:40:46.115017Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
title |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
spellingShingle |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions Garcia, Eduardo Anselmo Lymphatic vessel density VEGF-C Thyroid Thyroid cancer Vascular endothelial growth factor Tumor lymphangiogenesis Science & Technology |
title_short |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
title_full |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
title_fullStr |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
title_full_unstemmed |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
title_sort |
Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions |
author |
Garcia, Eduardo Anselmo |
author_facet |
Garcia, Eduardo Anselmo Simões, Kleber Wakamatsu, Alda Ressio, Rodrigo Albergaria Alves, Venâncio Avancini Ferreira Longatto Filho, Adhemar Camargo, Roberto Souza |
author_role |
author |
author2 |
Simões, Kleber Wakamatsu, Alda Ressio, Rodrigo Albergaria Alves, Venâncio Avancini Ferreira Longatto Filho, Adhemar Camargo, Roberto Souza |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Garcia, Eduardo Anselmo Simões, Kleber Wakamatsu, Alda Ressio, Rodrigo Albergaria Alves, Venâncio Avancini Ferreira Longatto Filho, Adhemar Camargo, Roberto Souza |
dc.subject.por.fl_str_mv |
Lymphatic vessel density VEGF-C Thyroid Thyroid cancer Vascular endothelial growth factor Tumor lymphangiogenesis Science & Technology |
topic |
Lymphatic vessel density VEGF-C Thyroid Thyroid cancer Vascular endothelial growth factor Tumor lymphangiogenesis Science & Technology |
description |
Thyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the value of LVD in benign and malignant thyroid lesions, we analyzed 110 thyroidectomy specimens using D2-40, a specific marker for lymphatic vessels and vascular endothelial growth factor C (VEGF-C), the most potent molecule of lymphatic proliferation. LVD was significantly different between papillary and follicular carcinomas in total (p = 0.045) and peritumoral area (p = 0.042). Follicular adenoma and follicular carcinoma showed an important difference of intra- (p = 0.019) and peritumoral (p = 0.033) LVD. VEGF-C was more markedly expressed in malignancies than in benign lesions (p = 0.0001). Almost all cancers with high positive VEGF-C expression also exhibited increased peritumoral LVD (p = 0.049) when compared with the benign lesions. Indeed, the high peritumoral LVD of malignant thyroid lesions is an important finding for surgery planning and supports the practice of total thyroidectomy in malignant thyroid neoplasm's since the lymphatic peritumoral vessels definitely are an escape path for tumor cells. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/29358 |
url |
http://hdl.handle.net/1822/29358 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1046-3976 10.1007/s12022-010-9116-9 20336393 http://link.springer.com/article/10.1007%2Fs12022-010-9116-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Humana Press |
publisher.none.fl_str_mv |
Humana Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132954288455680 |