Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/20435 |
Resumo: | Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from cortical function lateralization. It is not known, however, if other pain-associated behavioral changes are differentially affected by left- and right-sided pain. To test this hypothesis, the performance of rats with a unilateral spared nerve injury neuropathy installed in the left (SNI-L) or in the right (SNI-R) side was compared in anxiety (elevated-plus maze) and cognitive (spatial working and reference memory, attentional set-shifting task, and delay-to-signal impulsivity task) behavioral paradigms. Results show that SNI-L animals presented an increased anxiety-like profile while maintaining preserved cognitive function. On the contrary, SNI-R animals presented cognitive deficits in all tasks except in the reference memory, but displayed a normal anxiety-like profile. Our results show that left- and right-sided neuropathic pain differentially affects emotional behavior, which is in accordance with previous observations in human subjects, both in experimentally induced pain and in chronic pain conditions. Additionally, our results demonstrate that the cognitive function deterioration |
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Differential effects of left/right neuropathy on rats’ anxiety and cognitive behaviorCognitive behaviorEmotional behaviorLateralizationNeuropathic painRodentScience & TechnologyChronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from cortical function lateralization. It is not known, however, if other pain-associated behavioral changes are differentially affected by left- and right-sided pain. To test this hypothesis, the performance of rats with a unilateral spared nerve injury neuropathy installed in the left (SNI-L) or in the right (SNI-R) side was compared in anxiety (elevated-plus maze) and cognitive (spatial working and reference memory, attentional set-shifting task, and delay-to-signal impulsivity task) behavioral paradigms. Results show that SNI-L animals presented an increased anxiety-like profile while maintaining preserved cognitive function. On the contrary, SNI-R animals presented cognitive deficits in all tasks except in the reference memory, but displayed a normal anxiety-like profile. Our results show that left- and right-sided neuropathic pain differentially affects emotional behavior, which is in accordance with previous observations in human subjects, both in experimentally induced pain and in chronic pain conditions. Additionally, our results demonstrate that the cognitive function deteriorationThis work was funded by the Portuguese Science Foundation Project PTDC/SAU-NEU/108557/2008, COMPETE and FEDER, and Grant SFRH/BD/29166/2006ElsevierUniversidade do MinhoLeite-Almeida, HugoCerqueira, JoãoWei, HongRibeiro, Nuno CostaMartins, Helena AnjosSousa, NunoPertovaara, AnttiAlmeida, Armando2012-112012-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20435eng0304-395910.1016/j.pain.2012.07.00722925700http://dx.doi.org/10.1016/j.pain.2012.07.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:04ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
title |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
spellingShingle |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior Leite-Almeida, Hugo Cognitive behavior Emotional behavior Lateralization Neuropathic pain Rodent Science & Technology |
title_short |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
title_full |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
title_fullStr |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
title_full_unstemmed |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
title_sort |
Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior |
author |
Leite-Almeida, Hugo |
author_facet |
Leite-Almeida, Hugo Cerqueira, João Wei, Hong Ribeiro, Nuno Costa Martins, Helena Anjos Sousa, Nuno Pertovaara, Antti Almeida, Armando |
author_role |
author |
author2 |
Cerqueira, João Wei, Hong Ribeiro, Nuno Costa Martins, Helena Anjos Sousa, Nuno Pertovaara, Antti Almeida, Armando |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Leite-Almeida, Hugo Cerqueira, João Wei, Hong Ribeiro, Nuno Costa Martins, Helena Anjos Sousa, Nuno Pertovaara, Antti Almeida, Armando |
dc.subject.por.fl_str_mv |
Cognitive behavior Emotional behavior Lateralization Neuropathic pain Rodent Science & Technology |
topic |
Cognitive behavior Emotional behavior Lateralization Neuropathic pain Rodent Science & Technology |
description |
Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from cortical function lateralization. It is not known, however, if other pain-associated behavioral changes are differentially affected by left- and right-sided pain. To test this hypothesis, the performance of rats with a unilateral spared nerve injury neuropathy installed in the left (SNI-L) or in the right (SNI-R) side was compared in anxiety (elevated-plus maze) and cognitive (spatial working and reference memory, attentional set-shifting task, and delay-to-signal impulsivity task) behavioral paradigms. Results show that SNI-L animals presented an increased anxiety-like profile while maintaining preserved cognitive function. On the contrary, SNI-R animals presented cognitive deficits in all tasks except in the reference memory, but displayed a normal anxiety-like profile. Our results show that left- and right-sided neuropathic pain differentially affects emotional behavior, which is in accordance with previous observations in human subjects, both in experimentally induced pain and in chronic pain conditions. Additionally, our results demonstrate that the cognitive function deterioration |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11 2012-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/20435 |
url |
http://hdl.handle.net/1822/20435 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0304-3959 10.1016/j.pain.2012.07.007 22925700 http://dx.doi.org/10.1016/j.pain.2012.07.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303649985232896 |