Non-Hodgkin's lymphoma and Hodgkin disease - Consequence or associotion?

• Autor(a) principal: Alves, J.
• Data de Publicação: 1997
• Outros Autores: Lúcio, P., Frade, M. J., Panarra, A., Ventura, A., Riscado, M.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/2248
• topic: doença de Hodgkin; linfoma não Hodgkin; Linfoma composto; linfoma simultâneo; Linfoma sequencial; Hodgkin disease; non-Hodgkin lym­phoma; lymphoma composite; simultaneous lym­phoma; sequencial lymphoma

The occurrence of non-Hodgkin lymphoma in patients previously treated for Hodgkin's disea­se has already been described and is explained by an iatrogenic immunologic deficit. The authors describe a 60 year-old patient with Hodgkin's disease ( sclero-nodular) which in the course of therapy with MOPP developed a supe­rior vena cava syndrome dueto an "explosive proliferation" of mediastinal and cervical ade­ nopathies, histopathologically corresponding to a high-grade lymphoma B. The authors discuss the possible direct asso­ciation of both conditions, based in a common pathology. The conclusions clearly indicate the evidence of this association in the clinical case described, and emphasize the need to reevalua­te concepts, nowadays given as acquired, con­cerning the immunology and pathogenesis of the lympho proliferative syndromes.