Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)

Bibliographic Details
Main Author: Walker, Valentin
Publication Date: 2018
Other Authors: Crijns, Anne, Langendijk, Johannes, Spoor, Daan, Vliegenthart, Rozemarijn, Combs, Stephanie E., Mayinger, Michael, Eraso, Arantxa, Guedea, Ferran, Fiuza, Manuela, Santos, Susana Constantino Rosa, Tamarat, Radia, Laurier, Dominique, Ferrières, Jean, Mousseaux, Elie, Cardis, Elisabeth, Jacob, Sophie
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10451/38736
Summary: © Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 01.10.2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
id RCAP_7013fb8fa07b37f66ae5c6aba9d9d103
oai_identifier_str oai:repositorio.ul.pt:10451/38736
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)BiomarkersBreast cancerCardiotoxicityCardiac diagnostic imagingRadiotherapyRadiation dosimetry© Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 01.10.2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.Background: Breast cancer is the most common cancer among women, and radiotherapy plays a major role in its treatment. However, breast cancer radiotherapy can lead to incidental irradiation of the heart, resulting in an increased risk for a variety of heart diseases arising many years after radiotherapy. Therefore, identifying breast cancer patients at the highest risk for radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention, which may contribute to healthy aging. There is still a need for precise knowledge on the relationship between radiation dose to specific cardiac structures and early subclinical cardiac changes and their occurrence over time that could finally lead to cardiac complications. Objective: The MEDIRAD EARLY HEART study aims to identify and validate new cardiac imaging and circulating biomarkers of radiation-induced cardiovascular changes arising within first 2 years of breast cancer radiotherapy and to develop risk models integrating these biomarkers combined with precise dose metrics of cardiac structures based on three-dimensional dosimetry. Methods: The EARLY HEART study is a multicenter, prospective cohort study in which 250 women treated for breast cancer and followed for 2 years after radiotherapy will be included. Women treated with radiotherapy without chemotherapy for a unilateral breast cancer and aged 40-75 years meet the inclusion criteria. Baseline and follow-up data include cardiac measurements based on two-dimensional speckle-tracking echocardiography, computed tomography coronary angiography, cardiac magnetic resonance imaging, and a wide panel of circulating biomarkers of cardiac injury. The absorbed dose will be evaluated globally for the heart and different substructures. Furthermore, the dose-response relationship will allow modeling the radiation-induced occurrence and evolution of subclinical cardiac lesions and biomarkers to develop prediction models. Results: This study details the protocol of the MEDIRAD EARLY HEART study and presents the main limits and advantages of this international project. The inclusion of patients began in 2017. Preliminary results are expected to be published in 2019, and complete analysis should be published in 2021. Conclusions: The MEDIRAD EARLY HEART study will allow identifying the main cardiac imaging and blood-based determinants of radiation-induced cardiac injuries to better propose primary and secondary preventive measures in order to contribute to enhanced patient care and quality of life. Trial Registration: ClinicalTrials.gov NCT03297346; https://clinicaltrials.gov/ct2/show/NCT03297346 (Archived by WebCite at http://www.webcitation.org/72KS7MIUU) Registered Report Identifier: RR1-10.2196/9906JMIR PublicationsRepositório da Universidade de LisboaWalker, ValentinCrijns, AnneLangendijk, JohannesSpoor, DaanVliegenthart, RozemarijnCombs, Stephanie E.Mayinger, MichaelEraso, ArantxaGuedea, FerranFiuza, ManuelaSantos, Susana Constantino RosaTamarat, RadiaLaurier, DominiqueFerrières, JeanMousseaux, ElieCardis, ElisabethJacob, Sophie2019-06-18T16:03:37Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/38736engJMIR Res Protoc 2018;7(10):e1781929-074810.2196/resprot.9906info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:36:44Zoai:repositorio.ul.pt:10451/38736Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:52:32.844665Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
title Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
spellingShingle Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
Walker, Valentin
Biomarkers
Breast cancer
Cardiotoxicity
Cardiac diagnostic imaging
Radiotherapy
Radiation dosimetry
title_short Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
title_full Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
title_fullStr Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
title_full_unstemmed Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
title_sort Early detection of cardiovascular changes after radiotherapy for breast cancer : protocol for a european multicenter prospective cohort study (MEDIRAD EARLY HEART Study)
author Walker, Valentin
author_facet Walker, Valentin
Crijns, Anne
Langendijk, Johannes
Spoor, Daan
Vliegenthart, Rozemarijn
Combs, Stephanie E.
Mayinger, Michael
Eraso, Arantxa
Guedea, Ferran
Fiuza, Manuela
Santos, Susana Constantino Rosa
Tamarat, Radia
Laurier, Dominique
Ferrières, Jean
Mousseaux, Elie
Cardis, Elisabeth
Jacob, Sophie
author_role author
author2 Crijns, Anne
Langendijk, Johannes
Spoor, Daan
Vliegenthart, Rozemarijn
Combs, Stephanie E.
Mayinger, Michael
Eraso, Arantxa
Guedea, Ferran
Fiuza, Manuela
Santos, Susana Constantino Rosa
Tamarat, Radia
Laurier, Dominique
Ferrières, Jean
Mousseaux, Elie
Cardis, Elisabeth
Jacob, Sophie
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Walker, Valentin
Crijns, Anne
Langendijk, Johannes
Spoor, Daan
Vliegenthart, Rozemarijn
Combs, Stephanie E.
Mayinger, Michael
Eraso, Arantxa
Guedea, Ferran
Fiuza, Manuela
Santos, Susana Constantino Rosa
Tamarat, Radia
Laurier, Dominique
Ferrières, Jean
Mousseaux, Elie
Cardis, Elisabeth
Jacob, Sophie
dc.subject.por.fl_str_mv Biomarkers
Breast cancer
Cardiotoxicity
Cardiac diagnostic imaging
Radiotherapy
Radiation dosimetry
topic Biomarkers
Breast cancer
Cardiotoxicity
Cardiac diagnostic imaging
Radiotherapy
Radiation dosimetry
description © Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 01.10.2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-06-18T16:03:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/38736
url http://hdl.handle.net/10451/38736
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv JMIR Res Protoc 2018;7(10):e178
1929-0748
10.2196/resprot.9906
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv JMIR Publications
publisher.none.fl_str_mv JMIR Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134462006525952