TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis

Detalhes bibliográficos
Autor(a) principal: Coelho, Maria Teixeira
Data de Publicação: 2011
Outros Autores: Cruz, Andrea, Carmona, J. A., Sousa, Carole Lara Veiga de, Pereira, Daniela Maria Ramos, Saraiva, Ana Laura, Veldhoen, Marc, Pedrosa, Jorge, Castro, António G., Saraiva, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/17431
Resumo: The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.
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spelling TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosisTuberculosisTLRIL-23CytokinesScience & TechnologyThe authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-producing T cells, IL-17-producing T cells (Th17) have been observed during mycobacterial infections. Nevertheless, their contribution for the host immune response to mycobacteria as well as the signals triggering M. tuberculosis -specific Th17 cell differentiation and maintenance are not fully understood. We show that signaling via Toll-like receptor (TLR) 2 has a major impact on the regulation of p19 (IL-23) expression in response to M. tuberculosis and therefore on the establishment of Th17 cell responses to M. tuberculosis infection. Diminished Th17 responses in the lung of M. tuberculosis -infected TLR2-deficient animals were not caused by defective cell differentiation in the draining lymph node (LN) but rather by reduced maintenance at the site of infection. Consistent with the decreased numbers of Th17 cells in the lungs of infected TLR2-deficient animals, we observed reduced expression of CXCL9, CXCL10 and CXCL11, chemokines involved in recall responses to M. tuberculosis. Our data provides insights into the TLR2 role in infection with M. tuberculosis, with implications in pathophysiology of the disease and vaccine design.Fundação para a Ciência e Tecnologia, Portugal (Project Grants PTDC/SAU/70895/2006 to AGC and PTDC/BIA-BCM/102776/2008 to MS; and Personal Grants SRFH/BD/33034/2006 to MTC; SFRH/BPD/3306/2007 to AC; SFRH/BD/35981/2007 to JC; SFRH/BI/33456/2008 to CS and PTDC/SAU-MII/70895/2006 to DRP) and by the Health Service of Fundação Calouste Gulbenkian. MS is a Ciência 2007 Fellow.Oxford University PressUniversidade do MinhoCoelho, Maria TeixeiraCruz, AndreaCarmona, J. A.Sousa, Carole Lara Veiga dePereira, Daniela Maria RamosSaraiva, Ana LauraVeldhoen, MarcPedrosa, JorgeCastro, António G.Saraiva, Margarida2011-022011-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/17431eng0953-817810.1093/intimm/dxq45921156751http://intimm.oxfordjournals.org/content/23/2/89.abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:09:37Zoai:repositorium.sdum.uminho.pt:1822/17431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:01:03.186083Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
title TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
spellingShingle TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
Coelho, Maria Teixeira
Tuberculosis
TLR
IL-23
Cytokines
Science & Technology
title_short TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
title_full TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
title_fullStr TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
title_full_unstemmed TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
title_sort TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis
author Coelho, Maria Teixeira
author_facet Coelho, Maria Teixeira
Cruz, Andrea
Carmona, J. A.
Sousa, Carole Lara Veiga de
Pereira, Daniela Maria Ramos
Saraiva, Ana Laura
Veldhoen, Marc
Pedrosa, Jorge
Castro, António G.
Saraiva, Margarida
author_role author
author2 Cruz, Andrea
Carmona, J. A.
Sousa, Carole Lara Veiga de
Pereira, Daniela Maria Ramos
Saraiva, Ana Laura
Veldhoen, Marc
Pedrosa, Jorge
Castro, António G.
Saraiva, Margarida
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Coelho, Maria Teixeira
Cruz, Andrea
Carmona, J. A.
Sousa, Carole Lara Veiga de
Pereira, Daniela Maria Ramos
Saraiva, Ana Laura
Veldhoen, Marc
Pedrosa, Jorge
Castro, António G.
Saraiva, Margarida
dc.subject.por.fl_str_mv Tuberculosis
TLR
IL-23
Cytokines
Science & Technology
topic Tuberculosis
TLR
IL-23
Cytokines
Science & Technology
description The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
2011-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/17431
url http://hdl.handle.net/1822/17431
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0953-8178
10.1093/intimm/dxq459
21156751
http://intimm.oxfordjournals.org/content/23/2/89.abstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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