Intestinal barrier interactions with specialized CD8 T Cells

Bibliographic Details
Main Author: Konjar, Spela
Publication Date: 2017
Other Authors: Ferreira, Cristina, Blankenhaus, Birte, Veldhoen, Marc
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10451/49575
Summary: Copyright: © 2017 Konjar, Ferreira, Blankenhaus and Veldhoen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Intestinal barrier interactions with specialized CD8 T CellsCD8+ T-lymphocytesEpithelial cellsInflammatory bowel diseaseIntraepithelial lymphocytesMucosal immunologyCopyright: © 2017 Konjar, Ferreira, Blankenhaus and Veldhoen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The trillions of microorganisms that reside in the gastrointestinal tract, essential for nutrient absorption, are kept under control by a single cell barrier and large amounts of immune cells. Intestinal epithelial cells (IECs) are critical in establishing an environment supporting microbial colonization and immunological tolerance. A large population of CD8+ T cells is in direct and constant contact with the IECs and the intraepithelial lymphocytes (IELs). Due to their location, at the interphase of the intestinal lumen and external environment and the host tissues, they seem ideally positioned to balance immune tolerance and protection to preserve the fragile intestinal barrier from invasion as well as immunopathology. IELs are a heterogeneous population, with a large innate-like contribution of unknown specificity, intercalated with antigen-specific tissue-resident memory T cells. In this review, we provide a comprehensive overview of IEL physiology and how they interact with the IECs and contribute to immune surveillance to preserve intestinal homeostasis and host-microbial relationships.Members of the Veldhoen laboratory are supported by European Union H2020 ERA project (N°667824—EXCELLtoINNOV), publication costs were provided by LISBOA-01-0145-FEDER-007391, projeto cofinanciado pelo FEDER através POR Lisboa 2020—Programa Operacional Regional de Lisboa, do PORTUGAL 2020, e pela Fundação para a Ciência e a Tecnologia.FrontiersRepositório da Universidade de LisboaKonjar, SpelaFerreira, CristinaBlankenhaus, BirteVeldhoen, Marc2021-09-22T16:50:01Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49575engFront Immunol. 2017 Oct 11;8:128110.3389/fimmu.2017.012811664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:28Zoai:repositorio.ul.pt:10451/49575Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:12.384076Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Intestinal barrier interactions with specialized CD8 T Cells
title Intestinal barrier interactions with specialized CD8 T Cells
spellingShingle Intestinal barrier interactions with specialized CD8 T Cells
Konjar, Spela
CD8+ T-lymphocytes
Epithelial cells
Inflammatory bowel disease
Intraepithelial lymphocytes
Mucosal immunology
title_short Intestinal barrier interactions with specialized CD8 T Cells
title_full Intestinal barrier interactions with specialized CD8 T Cells
title_fullStr Intestinal barrier interactions with specialized CD8 T Cells
title_full_unstemmed Intestinal barrier interactions with specialized CD8 T Cells
title_sort Intestinal barrier interactions with specialized CD8 T Cells
author Konjar, Spela
author_facet Konjar, Spela
Ferreira, Cristina
Blankenhaus, Birte
Veldhoen, Marc
author_role author
author2 Ferreira, Cristina
Blankenhaus, Birte
Veldhoen, Marc
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Konjar, Spela
Ferreira, Cristina
Blankenhaus, Birte
Veldhoen, Marc
dc.subject.por.fl_str_mv CD8+ T-lymphocytes
Epithelial cells
Inflammatory bowel disease
Intraepithelial lymphocytes
Mucosal immunology
topic CD8+ T-lymphocytes
Epithelial cells
Inflammatory bowel disease
Intraepithelial lymphocytes
Mucosal immunology
description Copyright: © 2017 Konjar, Ferreira, Blankenhaus and Veldhoen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2021-09-22T16:50:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49575
url http://hdl.handle.net/10451/49575
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol. 2017 Oct 11;8:1281
10.3389/fimmu.2017.01281
1664-3224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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