Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

Detalhes bibliográficos
Autor(a) principal: Cammann, Victoria L.
Data de Publicação: 2021
Outros Autores: Scheitz, Jan F., von Rennenberg, Regina, Jäncke, Lutz, Nolte, Christian H., Szawan, Konrad A., Stengl, Helena, Würdinger, Michael, Endres, Matthias, Templin, Christian, Ghadri, Jelena R., Citro, Rodolfo, Vecchione, Carmine, Bossone, Eduardo, Gili, Sebastiano, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Miłosz, Noutsias, Michel, Knorr, Maike, Jansen, Thomas, D’Ascenzo, Fabrizio, Dichtl, Wolfgang, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang, Pott, Alexander, Meyer, Philippe, Roffi, Marco, Banning, Adrian, Wolfrum, Mathias, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Napp, L. Christian, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clément, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Poledniková, Karolina, Toušek, Petr, Winchester, David E., Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Hauck, Christian, Paolini, Carla, Bilato, Claudio, Kobayashi, Yoshio, Kato, Ken, Shoji, Toshihiro, Ishibashi, Iwao, Takahara, Masayuki, Himi, Toshiharu, Din, Jehangir, Al-Shammari, Ali, Prasad, Abhiram, Rihal, Charanjit S., Liu, Kan, Schulze, P. Christian, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Pestana, Gonçalo, Nguyen, Thanh H., Böhm, Michael, Maier, Lars S., Pinto, Fausto J., Widimský, Petr, Felix, Stephan B., Braun-Dullaeus, Ruediger C., Rottbauer, Wolfgang, Hasenfuß, Gerd, Pieske, Burkert M., Schunkert, Heribert, Budnik, Monika, Opolski, Grzegorz, Borggrefe, Martin, Thiele, Holger, Bauersachs, Johann, Katus, Hugo A., Horowitz, John D., Di Mario, Carlo, Münzel, Thomas, Crea, Filippo, Bax, Jeroen J., Scherff, Frank, Niederseer, David, Lüscher, Thomas F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50787
Resumo: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness.The International Takotsubo Registry was supported by the Biss Davies Charitable Trust. Dr. Scheitz has been supported by the Corona Foundation. Dr. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation.Springer NatureRepositório da Universidade de LisboaCammann, Victoria L.Scheitz, Jan F.von Rennenberg, ReginaJäncke, LutzNolte, Christian H.Szawan, Konrad A.Stengl, HelenaWürdinger, MichaelEndres, MatthiasTemplin, ChristianGhadri, Jelena R.Citro, RodolfoVecchione, CarmineBossone, EduardoGili, SebastianoNeuhaus, MichaelFranke, JenniferMeder, BenjaminJaguszewski, MiłoszNoutsias, MichelKnorr, MaikeJansen, ThomasD’Ascenzo, FabrizioDichtl, WolfgangBurgdorf, ChristofKherad, BehrouzTschöpe, CarstenSarcon, AnnahitaShinbane, JeroldRajan, LawrenceMichels, GuidoPfister, RomanCuneo, AlessandroJacobshagen, ClaudiusKarakas, MahirKoenig, WolfgangPott, AlexanderMeyer, PhilippeRoffi, MarcoBanning, AdrianWolfrum, MathiasCuculi, FlorimKobza, RichardFischer, Thomas A.Vasankari, TuijaAiraksinen, K. E. JuhaniNapp, L. ChristianDworakowski, RafalMacCarthy, PhilipKaiser, ChristophOsswald, StefanGaliuto, LeonardaChan, ChristinaBridgman, PaulBeug, DanielDelmas, ClémentLairez, OlivierGilyarova, EkaterinaShilova, AlexandraGilyarov, MikhailEl-Battrawy, IbrahimAkin, IbrahimPoledniková, KarolinaToušek, PetrWinchester, David E.Galuszka, JanUkena, ChristianPoglajen, GregorCarrilho-Ferreira, PedroHauck, ChristianPaolini, CarlaBilato, ClaudioKobayashi, YoshioKato, KenShoji, ToshihiroIshibashi, IwaoTakahara, MasayukiHimi, ToshiharuDin, JehangirAl-Shammari, AliPrasad, AbhiramRihal, Charanjit S.Liu, KanSchulze, P. ChristianBianco, MatteoJörg, LucasRickli, HansPestana, GonçaloNguyen, Thanh H.Böhm, MichaelMaier, Lars S.Pinto, Fausto J.Widimský, PetrFelix, Stephan B.Braun-Dullaeus, Ruediger C.Rottbauer, WolfgangHasenfuß, GerdPieske, Burkert M.Schunkert, HeribertBudnik, MonikaOpolski, GrzegorzBorggrefe, MartinThiele, HolgerBauersachs, JohannKatus, Hugo A.Horowitz, John D.Di Mario, CarloMünzel, ThomasCrea, FilippoBax, Jeroen J.Scherff, FrankNiederseer, DavidLüscher, Thomas F.2022-01-12T15:15:27Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50787engSci Rep. 2021 Dec 7;11(1):2355510.1038/s41598-021-01496-92045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:09Zoai:repositorio.ul.pt:10451/50787Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:10.809743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
title Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
spellingShingle Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
Cammann, Victoria L.
title_short Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
title_full Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
title_fullStr Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
title_full_unstemmed Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
title_sort Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
author Cammann, Victoria L.
author_facet Cammann, Victoria L.
Scheitz, Jan F.
von Rennenberg, Regina
Jäncke, Lutz
Nolte, Christian H.
Szawan, Konrad A.
Stengl, Helena
Würdinger, Michael
Endres, Matthias
Templin, Christian
Ghadri, Jelena R.
Citro, Rodolfo
Vecchione, Carmine
Bossone, Eduardo
Gili, Sebastiano
Neuhaus, Michael
Franke, Jennifer
Meder, Benjamin
Jaguszewski, Miłosz
Noutsias, Michel
Knorr, Maike
Jansen, Thomas
D’Ascenzo, Fabrizio
Dichtl, Wolfgang
Burgdorf, Christof
Kherad, Behrouz
Tschöpe, Carsten
Sarcon, Annahita
Shinbane, Jerold
Rajan, Lawrence
Michels, Guido
Pfister, Roman
Cuneo, Alessandro
Jacobshagen, Claudius
Karakas, Mahir
Koenig, Wolfgang
Pott, Alexander
Meyer, Philippe
Roffi, Marco
Banning, Adrian
Wolfrum, Mathias
Cuculi, Florim
Kobza, Richard
Fischer, Thomas A.
Vasankari, Tuija
Airaksinen, K. E. Juhani
Napp, L. Christian
Dworakowski, Rafal
MacCarthy, Philip
Kaiser, Christoph
Osswald, Stefan
Galiuto, Leonarda
Chan, Christina
Bridgman, Paul
Beug, Daniel
Delmas, Clément
Lairez, Olivier
Gilyarova, Ekaterina
Shilova, Alexandra
Gilyarov, Mikhail
El-Battrawy, Ibrahim
Akin, Ibrahim
Poledniková, Karolina
Toušek, Petr
Winchester, David E.
Galuszka, Jan
Ukena, Christian
Poglajen, Gregor
Carrilho-Ferreira, Pedro
Hauck, Christian
Paolini, Carla
Bilato, Claudio
Kobayashi, Yoshio
Kato, Ken
Shoji, Toshihiro
Ishibashi, Iwao
Takahara, Masayuki
Himi, Toshiharu
Din, Jehangir
Al-Shammari, Ali
Prasad, Abhiram
Rihal, Charanjit S.
Liu, Kan
Schulze, P. Christian
Bianco, Matteo
Jörg, Lucas
Rickli, Hans
Pestana, Gonçalo
Nguyen, Thanh H.
Böhm, Michael
Maier, Lars S.
Pinto, Fausto J.
Widimský, Petr
Felix, Stephan B.
Braun-Dullaeus, Ruediger C.
Rottbauer, Wolfgang
Hasenfuß, Gerd
Pieske, Burkert M.
Schunkert, Heribert
Budnik, Monika
Opolski, Grzegorz
Borggrefe, Martin
Thiele, Holger
Bauersachs, Johann
Katus, Hugo A.
Horowitz, John D.
Di Mario, Carlo
Münzel, Thomas
Crea, Filippo
Bax, Jeroen J.
Scherff, Frank
Niederseer, David
Lüscher, Thomas F.
author_role author
author2 Scheitz, Jan F.
von Rennenberg, Regina
Jäncke, Lutz
Nolte, Christian H.
Szawan, Konrad A.
Stengl, Helena
Würdinger, Michael
Endres, Matthias
Templin, Christian
Ghadri, Jelena R.
Citro, Rodolfo
Vecchione, Carmine
Bossone, Eduardo
Gili, Sebastiano
Neuhaus, Michael
Franke, Jennifer
Meder, Benjamin
Jaguszewski, Miłosz
Noutsias, Michel
Knorr, Maike
Jansen, Thomas
D’Ascenzo, Fabrizio
Dichtl, Wolfgang
Burgdorf, Christof
Kherad, Behrouz
Tschöpe, Carsten
Sarcon, Annahita
Shinbane, Jerold
Rajan, Lawrence
Michels, Guido
Pfister, Roman
Cuneo, Alessandro
Jacobshagen, Claudius
Karakas, Mahir
Koenig, Wolfgang
Pott, Alexander
Meyer, Philippe
Roffi, Marco
Banning, Adrian
Wolfrum, Mathias
Cuculi, Florim
Kobza, Richard
Fischer, Thomas A.
Vasankari, Tuija
Airaksinen, K. E. Juhani
Napp, L. Christian
Dworakowski, Rafal
MacCarthy, Philip
Kaiser, Christoph
Osswald, Stefan
Galiuto, Leonarda
Chan, Christina
Bridgman, Paul
Beug, Daniel
Delmas, Clément
Lairez, Olivier
Gilyarova, Ekaterina
Shilova, Alexandra
Gilyarov, Mikhail
El-Battrawy, Ibrahim
Akin, Ibrahim
Poledniková, Karolina
Toušek, Petr
Winchester, David E.
Galuszka, Jan
Ukena, Christian
Poglajen, Gregor
Carrilho-Ferreira, Pedro
Hauck, Christian
Paolini, Carla
Bilato, Claudio
Kobayashi, Yoshio
Kato, Ken
Shoji, Toshihiro
Ishibashi, Iwao
Takahara, Masayuki
Himi, Toshiharu
Din, Jehangir
Al-Shammari, Ali
Prasad, Abhiram
Rihal, Charanjit S.
Liu, Kan
Schulze, P. Christian
Bianco, Matteo
Jörg, Lucas
Rickli, Hans
Pestana, Gonçalo
Nguyen, Thanh H.
Böhm, Michael
Maier, Lars S.
Pinto, Fausto J.
Widimský, Petr
Felix, Stephan B.
Braun-Dullaeus, Ruediger C.
Rottbauer, Wolfgang
Hasenfuß, Gerd
Pieske, Burkert M.
Schunkert, Heribert
Budnik, Monika
Opolski, Grzegorz
Borggrefe, Martin
Thiele, Holger
Bauersachs, Johann
Katus, Hugo A.
Horowitz, John D.
Di Mario, Carlo
Münzel, Thomas
Crea, Filippo
Bax, Jeroen J.
Scherff, Frank
Niederseer, David
Lüscher, Thomas F.
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cammann, Victoria L.
Scheitz, Jan F.
von Rennenberg, Regina
Jäncke, Lutz
Nolte, Christian H.
Szawan, Konrad A.
Stengl, Helena
Würdinger, Michael
Endres, Matthias
Templin, Christian
Ghadri, Jelena R.
Citro, Rodolfo
Vecchione, Carmine
Bossone, Eduardo
Gili, Sebastiano
Neuhaus, Michael
Franke, Jennifer
Meder, Benjamin
Jaguszewski, Miłosz
Noutsias, Michel
Knorr, Maike
Jansen, Thomas
D’Ascenzo, Fabrizio
Dichtl, Wolfgang
Burgdorf, Christof
Kherad, Behrouz
Tschöpe, Carsten
Sarcon, Annahita
Shinbane, Jerold
Rajan, Lawrence
Michels, Guido
Pfister, Roman
Cuneo, Alessandro
Jacobshagen, Claudius
Karakas, Mahir
Koenig, Wolfgang
Pott, Alexander
Meyer, Philippe
Roffi, Marco
Banning, Adrian
Wolfrum, Mathias
Cuculi, Florim
Kobza, Richard
Fischer, Thomas A.
Vasankari, Tuija
Airaksinen, K. E. Juhani
Napp, L. Christian
Dworakowski, Rafal
MacCarthy, Philip
Kaiser, Christoph
Osswald, Stefan
Galiuto, Leonarda
Chan, Christina
Bridgman, Paul
Beug, Daniel
Delmas, Clément
Lairez, Olivier
Gilyarova, Ekaterina
Shilova, Alexandra
Gilyarov, Mikhail
El-Battrawy, Ibrahim
Akin, Ibrahim
Poledniková, Karolina
Toušek, Petr
Winchester, David E.
Galuszka, Jan
Ukena, Christian
Poglajen, Gregor
Carrilho-Ferreira, Pedro
Hauck, Christian
Paolini, Carla
Bilato, Claudio
Kobayashi, Yoshio
Kato, Ken
Shoji, Toshihiro
Ishibashi, Iwao
Takahara, Masayuki
Himi, Toshiharu
Din, Jehangir
Al-Shammari, Ali
Prasad, Abhiram
Rihal, Charanjit S.
Liu, Kan
Schulze, P. Christian
Bianco, Matteo
Jörg, Lucas
Rickli, Hans
Pestana, Gonçalo
Nguyen, Thanh H.
Böhm, Michael
Maier, Lars S.
Pinto, Fausto J.
Widimský, Petr
Felix, Stephan B.
Braun-Dullaeus, Ruediger C.
Rottbauer, Wolfgang
Hasenfuß, Gerd
Pieske, Burkert M.
Schunkert, Heribert
Budnik, Monika
Opolski, Grzegorz
Borggrefe, Martin
Thiele, Holger
Bauersachs, Johann
Katus, Hugo A.
Horowitz, John D.
Di Mario, Carlo
Münzel, Thomas
Crea, Filippo
Bax, Jeroen J.
Scherff, Frank
Niederseer, David
Lüscher, Thomas F.
description © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-01-12T15:15:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50787
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