Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50787 |
Resumo: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
id |
RCAP_73f9431adfdda994f4e44c10c5a214c1 |
---|---|
oai_identifier_str |
oai:repositorio.ul.pt:10451/50787 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness.The International Takotsubo Registry was supported by the Biss Davies Charitable Trust. Dr. Scheitz has been supported by the Corona Foundation. Dr. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation.Springer NatureRepositório da Universidade de LisboaCammann, Victoria L.Scheitz, Jan F.von Rennenberg, ReginaJäncke, LutzNolte, Christian H.Szawan, Konrad A.Stengl, HelenaWürdinger, MichaelEndres, MatthiasTemplin, ChristianGhadri, Jelena R.Citro, RodolfoVecchione, CarmineBossone, EduardoGili, SebastianoNeuhaus, MichaelFranke, JenniferMeder, BenjaminJaguszewski, MiłoszNoutsias, MichelKnorr, MaikeJansen, ThomasD’Ascenzo, FabrizioDichtl, WolfgangBurgdorf, ChristofKherad, BehrouzTschöpe, CarstenSarcon, AnnahitaShinbane, JeroldRajan, LawrenceMichels, GuidoPfister, RomanCuneo, AlessandroJacobshagen, ClaudiusKarakas, MahirKoenig, WolfgangPott, AlexanderMeyer, PhilippeRoffi, MarcoBanning, AdrianWolfrum, MathiasCuculi, FlorimKobza, RichardFischer, Thomas A.Vasankari, TuijaAiraksinen, K. E. JuhaniNapp, L. ChristianDworakowski, RafalMacCarthy, PhilipKaiser, ChristophOsswald, StefanGaliuto, LeonardaChan, ChristinaBridgman, PaulBeug, DanielDelmas, ClémentLairez, OlivierGilyarova, EkaterinaShilova, AlexandraGilyarov, MikhailEl-Battrawy, IbrahimAkin, IbrahimPoledniková, KarolinaToušek, PetrWinchester, David E.Galuszka, JanUkena, ChristianPoglajen, GregorCarrilho-Ferreira, PedroHauck, ChristianPaolini, CarlaBilato, ClaudioKobayashi, YoshioKato, KenShoji, ToshihiroIshibashi, IwaoTakahara, MasayukiHimi, ToshiharuDin, JehangirAl-Shammari, AliPrasad, AbhiramRihal, Charanjit S.Liu, KanSchulze, P. ChristianBianco, MatteoJörg, LucasRickli, HansPestana, GonçaloNguyen, Thanh H.Böhm, MichaelMaier, Lars S.Pinto, Fausto J.Widimský, PetrFelix, Stephan B.Braun-Dullaeus, Ruediger C.Rottbauer, WolfgangHasenfuß, GerdPieske, Burkert M.Schunkert, HeribertBudnik, MonikaOpolski, GrzegorzBorggrefe, MartinThiele, HolgerBauersachs, JohannKatus, Hugo A.Horowitz, John D.Di Mario, CarloMünzel, ThomasCrea, FilippoBax, Jeroen J.Scherff, FrankNiederseer, DavidLüscher, Thomas F.2022-01-12T15:15:27Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50787engSci Rep. 2021 Dec 7;11(1):2355510.1038/s41598-021-01496-92045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:09Zoai:repositorio.ul.pt:10451/50787Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:10.809743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
title |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
spellingShingle |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome Cammann, Victoria L. |
title_short |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
title_full |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
title_fullStr |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
title_full_unstemmed |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
title_sort |
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome |
author |
Cammann, Victoria L. |
author_facet |
Cammann, Victoria L. Scheitz, Jan F. von Rennenberg, Regina Jäncke, Lutz Nolte, Christian H. Szawan, Konrad A. Stengl, Helena Würdinger, Michael Endres, Matthias Templin, Christian Ghadri, Jelena R. Citro, Rodolfo Vecchione, Carmine Bossone, Eduardo Gili, Sebastiano Neuhaus, Michael Franke, Jennifer Meder, Benjamin Jaguszewski, Miłosz Noutsias, Michel Knorr, Maike Jansen, Thomas D’Ascenzo, Fabrizio Dichtl, Wolfgang Burgdorf, Christof Kherad, Behrouz Tschöpe, Carsten Sarcon, Annahita Shinbane, Jerold Rajan, Lawrence Michels, Guido Pfister, Roman Cuneo, Alessandro Jacobshagen, Claudius Karakas, Mahir Koenig, Wolfgang Pott, Alexander Meyer, Philippe Roffi, Marco Banning, Adrian Wolfrum, Mathias Cuculi, Florim Kobza, Richard Fischer, Thomas A. Vasankari, Tuija Airaksinen, K. E. Juhani Napp, L. Christian Dworakowski, Rafal MacCarthy, Philip Kaiser, Christoph Osswald, Stefan Galiuto, Leonarda Chan, Christina Bridgman, Paul Beug, Daniel Delmas, Clément Lairez, Olivier Gilyarova, Ekaterina Shilova, Alexandra Gilyarov, Mikhail El-Battrawy, Ibrahim Akin, Ibrahim Poledniková, Karolina Toušek, Petr Winchester, David E. Galuszka, Jan Ukena, Christian Poglajen, Gregor Carrilho-Ferreira, Pedro Hauck, Christian Paolini, Carla Bilato, Claudio Kobayashi, Yoshio Kato, Ken Shoji, Toshihiro Ishibashi, Iwao Takahara, Masayuki Himi, Toshiharu Din, Jehangir Al-Shammari, Ali Prasad, Abhiram Rihal, Charanjit S. Liu, Kan Schulze, P. Christian Bianco, Matteo Jörg, Lucas Rickli, Hans Pestana, Gonçalo Nguyen, Thanh H. Böhm, Michael Maier, Lars S. Pinto, Fausto J. Widimský, Petr Felix, Stephan B. Braun-Dullaeus, Ruediger C. Rottbauer, Wolfgang Hasenfuß, Gerd Pieske, Burkert M. Schunkert, Heribert Budnik, Monika Opolski, Grzegorz Borggrefe, Martin Thiele, Holger Bauersachs, Johann Katus, Hugo A. Horowitz, John D. Di Mario, Carlo Münzel, Thomas Crea, Filippo Bax, Jeroen J. Scherff, Frank Niederseer, David Lüscher, Thomas F. |
author_role |
author |
author2 |
Scheitz, Jan F. von Rennenberg, Regina Jäncke, Lutz Nolte, Christian H. Szawan, Konrad A. Stengl, Helena Würdinger, Michael Endres, Matthias Templin, Christian Ghadri, Jelena R. Citro, Rodolfo Vecchione, Carmine Bossone, Eduardo Gili, Sebastiano Neuhaus, Michael Franke, Jennifer Meder, Benjamin Jaguszewski, Miłosz Noutsias, Michel Knorr, Maike Jansen, Thomas D’Ascenzo, Fabrizio Dichtl, Wolfgang Burgdorf, Christof Kherad, Behrouz Tschöpe, Carsten Sarcon, Annahita Shinbane, Jerold Rajan, Lawrence Michels, Guido Pfister, Roman Cuneo, Alessandro Jacobshagen, Claudius Karakas, Mahir Koenig, Wolfgang Pott, Alexander Meyer, Philippe Roffi, Marco Banning, Adrian Wolfrum, Mathias Cuculi, Florim Kobza, Richard Fischer, Thomas A. Vasankari, Tuija Airaksinen, K. E. Juhani Napp, L. Christian Dworakowski, Rafal MacCarthy, Philip Kaiser, Christoph Osswald, Stefan Galiuto, Leonarda Chan, Christina Bridgman, Paul Beug, Daniel Delmas, Clément Lairez, Olivier Gilyarova, Ekaterina Shilova, Alexandra Gilyarov, Mikhail El-Battrawy, Ibrahim Akin, Ibrahim Poledniková, Karolina Toušek, Petr Winchester, David E. Galuszka, Jan Ukena, Christian Poglajen, Gregor Carrilho-Ferreira, Pedro Hauck, Christian Paolini, Carla Bilato, Claudio Kobayashi, Yoshio Kato, Ken Shoji, Toshihiro Ishibashi, Iwao Takahara, Masayuki Himi, Toshiharu Din, Jehangir Al-Shammari, Ali Prasad, Abhiram Rihal, Charanjit S. Liu, Kan Schulze, P. Christian Bianco, Matteo Jörg, Lucas Rickli, Hans Pestana, Gonçalo Nguyen, Thanh H. Böhm, Michael Maier, Lars S. Pinto, Fausto J. Widimský, Petr Felix, Stephan B. Braun-Dullaeus, Ruediger C. Rottbauer, Wolfgang Hasenfuß, Gerd Pieske, Burkert M. Schunkert, Heribert Budnik, Monika Opolski, Grzegorz Borggrefe, Martin Thiele, Holger Bauersachs, Johann Katus, Hugo A. Horowitz, John D. Di Mario, Carlo Münzel, Thomas Crea, Filippo Bax, Jeroen J. Scherff, Frank Niederseer, David Lüscher, Thomas F. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Cammann, Victoria L. Scheitz, Jan F. von Rennenberg, Regina Jäncke, Lutz Nolte, Christian H. Szawan, Konrad A. Stengl, Helena Würdinger, Michael Endres, Matthias Templin, Christian Ghadri, Jelena R. Citro, Rodolfo Vecchione, Carmine Bossone, Eduardo Gili, Sebastiano Neuhaus, Michael Franke, Jennifer Meder, Benjamin Jaguszewski, Miłosz Noutsias, Michel Knorr, Maike Jansen, Thomas D’Ascenzo, Fabrizio Dichtl, Wolfgang Burgdorf, Christof Kherad, Behrouz Tschöpe, Carsten Sarcon, Annahita Shinbane, Jerold Rajan, Lawrence Michels, Guido Pfister, Roman Cuneo, Alessandro Jacobshagen, Claudius Karakas, Mahir Koenig, Wolfgang Pott, Alexander Meyer, Philippe Roffi, Marco Banning, Adrian Wolfrum, Mathias Cuculi, Florim Kobza, Richard Fischer, Thomas A. Vasankari, Tuija Airaksinen, K. E. Juhani Napp, L. Christian Dworakowski, Rafal MacCarthy, Philip Kaiser, Christoph Osswald, Stefan Galiuto, Leonarda Chan, Christina Bridgman, Paul Beug, Daniel Delmas, Clément Lairez, Olivier Gilyarova, Ekaterina Shilova, Alexandra Gilyarov, Mikhail El-Battrawy, Ibrahim Akin, Ibrahim Poledniková, Karolina Toušek, Petr Winchester, David E. Galuszka, Jan Ukena, Christian Poglajen, Gregor Carrilho-Ferreira, Pedro Hauck, Christian Paolini, Carla Bilato, Claudio Kobayashi, Yoshio Kato, Ken Shoji, Toshihiro Ishibashi, Iwao Takahara, Masayuki Himi, Toshiharu Din, Jehangir Al-Shammari, Ali Prasad, Abhiram Rihal, Charanjit S. Liu, Kan Schulze, P. Christian Bianco, Matteo Jörg, Lucas Rickli, Hans Pestana, Gonçalo Nguyen, Thanh H. Böhm, Michael Maier, Lars S. Pinto, Fausto J. Widimský, Petr Felix, Stephan B. Braun-Dullaeus, Ruediger C. Rottbauer, Wolfgang Hasenfuß, Gerd Pieske, Burkert M. Schunkert, Heribert Budnik, Monika Opolski, Grzegorz Borggrefe, Martin Thiele, Holger Bauersachs, Johann Katus, Hugo A. Horowitz, John D. Di Mario, Carlo Münzel, Thomas Crea, Filippo Bax, Jeroen J. Scherff, Frank Niederseer, David Lüscher, Thomas F. |
description |
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-01-12T15:15:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50787 |
url |
http://hdl.handle.net/10451/50787 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sci Rep. 2021 Dec 7;11(1):23555 10.1038/s41598-021-01496-9 2045-2322 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134571276533760 |