Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis
Main Author: | |
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Publication Date: | 2014 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.16/1827 |
Summary: | BACKGROUND: Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport. METHODS: We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified. RESULTS: Effluent HGF negatively correlated with UF (r=-0.80, p=0.009) and FWT (r=-0.69, p=0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p=0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p=0.08). FWT≤45% without clinical UFF was documented in some patients who also had increased effluent HGF. CONCLUSIONS: Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration. |
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Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysisHepatocyte growth factorPeritoneal membraneUltrafiltration failureWater transportBACKGROUND: Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport. METHODS: We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified. RESULTS: Effluent HGF negatively correlated with UF (r=-0.80, p=0.009) and FWT (r=-0.69, p=0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p=0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p=0.08). FWT≤45% without clinical UFF was documented in some patients who also had increased effluent HGF. CONCLUSIONS: Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration.This study was partially performed with the help of investigations grants from Sociedade Portuguesa de Nefrologia. This work was also supported by UMIB/ICBAS – University of Porto (UP). Multidisciplinary Unit for Biomedical Research (UMIB) is funded by grants from Foundation for Science and Technology (Fcomp-01-0124-FEDER-015896)BioMed CentralRepositório Científico do Centro Hospitalar Universitário de Santo AntónioBernardo, A.Oliveira, J.Santos, O.Carvalho, M.Cabrita, A.Rodrigues, A.2015-07-21T11:23:17Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1827engBMC Nephrol. 2014;15:2011471-236910.1186/1471-2369-15-201info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:57:37Zoai:repositorio.chporto.pt:10400.16/1827Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:09.520283Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
title |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
spellingShingle |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis Bernardo, A. Hepatocyte growth factor Peritoneal membrane Ultrafiltration failure Water transport |
title_short |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
title_full |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
title_fullStr |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
title_full_unstemmed |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
title_sort |
Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis |
author |
Bernardo, A. |
author_facet |
Bernardo, A. Oliveira, J. Santos, O. Carvalho, M. Cabrita, A. Rodrigues, A. |
author_role |
author |
author2 |
Oliveira, J. Santos, O. Carvalho, M. Cabrita, A. Rodrigues, A. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Bernardo, A. Oliveira, J. Santos, O. Carvalho, M. Cabrita, A. Rodrigues, A. |
dc.subject.por.fl_str_mv |
Hepatocyte growth factor Peritoneal membrane Ultrafiltration failure Water transport |
topic |
Hepatocyte growth factor Peritoneal membrane Ultrafiltration failure Water transport |
description |
BACKGROUND: Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport. METHODS: We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified. RESULTS: Effluent HGF negatively correlated with UF (r=-0.80, p=0.009) and FWT (r=-0.69, p=0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p=0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p=0.08). FWT≤45% without clinical UFF was documented in some patients who also had increased effluent HGF. CONCLUSIONS: Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2015-07-21T11:23:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/1827 |
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http://hdl.handle.net/10400.16/1827 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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BMC Nephrol. 2014;15:201 1471-2369 10.1186/1471-2369-15-201 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BioMed Central |
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BioMed Central |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133643341299712 |