The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer

Detalhes bibliográficos
Autor(a) principal: Silva, Inês Hilário
Data de Publicação: 2013
Outros Autores: Silva, Cristina Nogueira, Figueiredo, Tiago, Lombo, Liliana, Faustino, Ilda, Catarino, Raquel, Nogueira, Augusto, Pereira, Deolinda, Medeiros, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/28252
Resumo: Uncorrected proof
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spelling The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancercervical cancerGGHPolymorphismCisplatin responseolymorphismScience & TechnologyUncorrected proofAims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the clinical data of 167 patients with bulky cervical cancer submitted to cisplatin-based chemoradiotherapy. The genotypes of GGH -401C > T SNP were determined by real-time PCR and statistical analysis was performed by chi(2) test and survival analysis. Results: The genotypes of GGH-401C > T were significantly associated with the response to platinum-based chemoradiotherapy. Treatment response was higher in patients carrying the CC genotype, who presented a significant increased chance of treatment response (survival time in months/genotype: 91 for CC Vs 72 for CT/TT; p = 0.035, log rank test). A Cox regression analysis accordingly showed that the presence of the T allele was significantly linked to a worse treatment response (HR = 3.036; CI 95% 1.032-8.934, p = 0.044). Conclusions: The results of our study suggested the potential interest of GGH -401C > T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy. (c) 2012 Elsevier B.V. All rights reserved.The authors thank the Liga Portuguesa Contra o Cancro - Centro Regional do Norte (LPCC - Portuguese League against Cancer). We gratefully acknowledge the funding of this work by the Minister of Health of Portugal (Comissao de Fomento da Investigacao em Cuidados de Saude).ElsevierUniversidade do MinhoSilva, Inês HilárioSilva, Cristina NogueiraFigueiredo, TiagoLombo, LilianaFaustino, IldaCatarino, RaquelNogueira, AugustoPereira, DeolindaMedeiros, Rui20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/28252eng0378-111910.1016/j.gene.2012.10.03823107767http://www.journals.elsevier.com/gene/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:46:03ZPortal AgregadorONG
dc.title.none.fl_str_mv The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
title The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
spellingShingle The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
Silva, Inês Hilário
cervical cancer
GGH
Polymorphism
Cisplatin response
olymorphism
Science & Technology
title_short The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
title_full The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
title_fullStr The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
title_full_unstemmed The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
title_sort The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer
author Silva, Inês Hilário
author_facet Silva, Inês Hilário
Silva, Cristina Nogueira
Figueiredo, Tiago
Lombo, Liliana
Faustino, Ilda
Catarino, Raquel
Nogueira, Augusto
Pereira, Deolinda
Medeiros, Rui
author_role author
author2 Silva, Cristina Nogueira
Figueiredo, Tiago
Lombo, Liliana
Faustino, Ilda
Catarino, Raquel
Nogueira, Augusto
Pereira, Deolinda
Medeiros, Rui
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Inês Hilário
Silva, Cristina Nogueira
Figueiredo, Tiago
Lombo, Liliana
Faustino, Ilda
Catarino, Raquel
Nogueira, Augusto
Pereira, Deolinda
Medeiros, Rui
dc.subject.por.fl_str_mv cervical cancer
GGH
Polymorphism
Cisplatin response
olymorphism
Science & Technology
topic cervical cancer
GGH
Polymorphism
Cisplatin response
olymorphism
Science & Technology
description Uncorrected proof
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/28252
url http://hdl.handle.net/1822/28252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-1119
10.1016/j.gene.2012.10.038
23107767
http://www.journals.elsevier.com/gene/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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