Urinary porphyrin excretion in normal children and adolescentes

Detalhes bibliográficos
Autor(a) principal: Woods, James S.
Data de Publicação: 2009
Outros Autores: Martin, Michael D., Leroux, Brian G., DeRouen, Timothy A., Bernardo, Mario F., Luis, Henrique S., Leitão, Jorge G., Simmonds, P. Lynne, Rue, Tessa C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/34275
Resumo: Background—Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable. Methods—Subjects were participants in a prospective, randomized, controlled clinical trial of dental materials safety, 8 to 12 y at inception, who were followed longitudinally for 7 y after baseline with an extensive battery of neurobehavioral, neurological, renal function and urinary porphyrin assessments. Porphyrins were quantified by HPLC. Linear regression analyses were used to measure associations of porphyrin levels with age and gender. Results—Mean concentrations, 95% confidence intervals, and 10th 50th, and 90th percentiles for all 5 typically excreted urinary porphyrins are presented by year of age and by gender. Unadjusted urinary concentrations (μg/l) of all 5 porphyrins remained relatively constant throughout the age range of 8–18 y for both males and females. In contrast, creatinine-adjusted urinary porphyrin concentrations (μg/g) declined significantly throughout this age range in both genders. Boys had significantly higher pentacarboxyl- and copro- porphyrin levels compared with girls both before and after creatinine adjustment. Conclusions—Normative longitudinal data provided herein may facilitate the clinical assessment of pediatric metabolic disorders and may be of particular relevance in evaluating porphyrin changes as a biological indicator of disease or xenobiotic exposures among children and adolescents.
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spelling Urinary porphyrin excretion in normal children and adolescentesUrinePorphyrinsChildrenAdolescentsBackground—Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable. Methods—Subjects were participants in a prospective, randomized, controlled clinical trial of dental materials safety, 8 to 12 y at inception, who were followed longitudinally for 7 y after baseline with an extensive battery of neurobehavioral, neurological, renal function and urinary porphyrin assessments. Porphyrins were quantified by HPLC. Linear regression analyses were used to measure associations of porphyrin levels with age and gender. Results—Mean concentrations, 95% confidence intervals, and 10th 50th, and 90th percentiles for all 5 typically excreted urinary porphyrins are presented by year of age and by gender. Unadjusted urinary concentrations (μg/l) of all 5 porphyrins remained relatively constant throughout the age range of 8–18 y for both males and females. In contrast, creatinine-adjusted urinary porphyrin concentrations (μg/g) declined significantly throughout this age range in both genders. Boys had significantly higher pentacarboxyl- and copro- porphyrin levels compared with girls both before and after creatinine adjustment. Conclusions—Normative longitudinal data provided herein may facilitate the clinical assessment of pediatric metabolic disorders and may be of particular relevance in evaluating porphyrin changes as a biological indicator of disease or xenobiotic exposures among children and adolescents.Repositório da Universidade de LisboaWoods, James S.Martin, Michael D.Leroux, Brian G.DeRouen, Timothy A.Bernardo, Mario F.Luis, Henrique S.Leitão, Jorge G.Simmonds, P. LynneRue, Tessa C.2018-07-20T15:01:37Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/34275engWoods JS, Martin MD, Leroux BG, et al. Urinary porphyrin excretion in normal children and adolescentes. Clin Chim Acta. 2009;405(1-2):104-109.10.1016/j.cca.2009.04.014.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:29:05Zoai:repositorio.ul.pt:10451/34275Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:48:50.389651Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Urinary porphyrin excretion in normal children and adolescentes
title Urinary porphyrin excretion in normal children and adolescentes
spellingShingle Urinary porphyrin excretion in normal children and adolescentes
Woods, James S.
Urine
Porphyrins
Children
Adolescents
title_short Urinary porphyrin excretion in normal children and adolescentes
title_full Urinary porphyrin excretion in normal children and adolescentes
title_fullStr Urinary porphyrin excretion in normal children and adolescentes
title_full_unstemmed Urinary porphyrin excretion in normal children and adolescentes
title_sort Urinary porphyrin excretion in normal children and adolescentes
author Woods, James S.
author_facet Woods, James S.
Martin, Michael D.
Leroux, Brian G.
DeRouen, Timothy A.
Bernardo, Mario F.
Luis, Henrique S.
Leitão, Jorge G.
Simmonds, P. Lynne
Rue, Tessa C.
author_role author
author2 Martin, Michael D.
Leroux, Brian G.
DeRouen, Timothy A.
Bernardo, Mario F.
Luis, Henrique S.
Leitão, Jorge G.
Simmonds, P. Lynne
Rue, Tessa C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Woods, James S.
Martin, Michael D.
Leroux, Brian G.
DeRouen, Timothy A.
Bernardo, Mario F.
Luis, Henrique S.
Leitão, Jorge G.
Simmonds, P. Lynne
Rue, Tessa C.
dc.subject.por.fl_str_mv Urine
Porphyrins
Children
Adolescents
topic Urine
Porphyrins
Children
Adolescents
description Background—Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable. Methods—Subjects were participants in a prospective, randomized, controlled clinical trial of dental materials safety, 8 to 12 y at inception, who were followed longitudinally for 7 y after baseline with an extensive battery of neurobehavioral, neurological, renal function and urinary porphyrin assessments. Porphyrins were quantified by HPLC. Linear regression analyses were used to measure associations of porphyrin levels with age and gender. Results—Mean concentrations, 95% confidence intervals, and 10th 50th, and 90th percentiles for all 5 typically excreted urinary porphyrins are presented by year of age and by gender. Unadjusted urinary concentrations (μg/l) of all 5 porphyrins remained relatively constant throughout the age range of 8–18 y for both males and females. In contrast, creatinine-adjusted urinary porphyrin concentrations (μg/g) declined significantly throughout this age range in both genders. Boys had significantly higher pentacarboxyl- and copro- porphyrin levels compared with girls both before and after creatinine adjustment. Conclusions—Normative longitudinal data provided herein may facilitate the clinical assessment of pediatric metabolic disorders and may be of particular relevance in evaluating porphyrin changes as a biological indicator of disease or xenobiotic exposures among children and adolescents.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2018-07-20T15:01:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/34275
url http://hdl.handle.net/10451/34275
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Woods JS, Martin MD, Leroux BG, et al. Urinary porphyrin excretion in normal children and adolescentes. Clin Chim Acta. 2009;405(1-2):104-109.
10.1016/j.cca.2009.04.014.
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