Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?

Detalhes bibliográficos
Autor(a) principal: Rocha, Jaqueline
Data de Publicação: 2022
Outros Autores: Ferreira, Catarina, Mil-Homens, Dalila, Busquets, Antonio, Fialho, Arsénio M, Henriques, Isabel, Gomila, Margarita, Manaia, Célia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/98759
https://doi.org/10.1186/s12864-021-08279-6
Resumo: Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses.
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spelling Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?Antibiotic resistanceClinicalComparative genomicsKlebsiella pneumoniaeWastewaterAnti-Bacterial AgentsCephalosporinsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsWaste Waterbeta-LactamasesKlebsiella InfectionsKlebsiella pneumoniaeKlebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses.This work was also financed by FCT in the scope of the project UIDB/04565/2020 and UIDP/04565/2020 of the Research Unit Institute for Bioengineering and Biosciences - iBB and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB. The authors also acknowledge FCT (STARE Water JPI/0001/2013, NanoDiaBac ENMed/0001/2014, UID/Multi/50016/2019, UIDP/50017/2020 + UIDB/50017/2020). JR was supported by the International PhD Programme in Biotechnology BIOTECH.DOC (NORTE 08 5369 FSE 000007) and by FEMS Research and Training Grant (FEMS GO 2017 008).BMC2022-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/98759http://hdl.handle.net/10316/98759https://doi.org/10.1186/s12864-021-08279-6eng1471-2164Rocha, JaquelineFerreira, CatarinaMil-Homens, DalilaBusquets, AntonioFialho, Arsénio MHenriques, IsabelGomila, MargaritaManaia, Célia M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-02-08T21:42:26Zoai:estudogeral.uc.pt:10316/98759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:16:30.625788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
title Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
spellingShingle Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
Rocha, Jaqueline
Antibiotic resistance
Clinical
Comparative genomics
Klebsiella pneumoniae
Wastewater
Anti-Bacterial Agents
Cephalosporins
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Waste Water
beta-Lactamases
Klebsiella Infections
Klebsiella pneumoniae
title_short Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
title_full Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
title_fullStr Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
title_full_unstemmed Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
title_sort Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
author Rocha, Jaqueline
author_facet Rocha, Jaqueline
Ferreira, Catarina
Mil-Homens, Dalila
Busquets, Antonio
Fialho, Arsénio M
Henriques, Isabel
Gomila, Margarita
Manaia, Célia M.
author_role author
author2 Ferreira, Catarina
Mil-Homens, Dalila
Busquets, Antonio
Fialho, Arsénio M
Henriques, Isabel
Gomila, Margarita
Manaia, Célia M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Jaqueline
Ferreira, Catarina
Mil-Homens, Dalila
Busquets, Antonio
Fialho, Arsénio M
Henriques, Isabel
Gomila, Margarita
Manaia, Célia M.
dc.subject.por.fl_str_mv Antibiotic resistance
Clinical
Comparative genomics
Klebsiella pneumoniae
Wastewater
Anti-Bacterial Agents
Cephalosporins
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Waste Water
beta-Lactamases
Klebsiella Infections
Klebsiella pneumoniae
topic Antibiotic resistance
Clinical
Comparative genomics
Klebsiella pneumoniae
Wastewater
Anti-Bacterial Agents
Cephalosporins
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Waste Water
beta-Lactamases
Klebsiella Infections
Klebsiella pneumoniae
description Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/98759
http://hdl.handle.net/10316/98759
https://doi.org/10.1186/s12864-021-08279-6
url http://hdl.handle.net/10316/98759
https://doi.org/10.1186/s12864-021-08279-6
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2164
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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