Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors

Detalhes bibliográficos
Autor(a) principal: Torrente, María
Data de Publicação: 2022
Outros Autores: Blanco, Mariola, Franco, Fabio, Garitaonaindia, Yago, Calvo, Virginia, Collazo-Lorduy, Ana, Gutiérrez, Lourdes, Sánchez, Juan Cristóbal, González-del-Alba, Aranzazu, Hernández, Roberto, Méndez, Miriam, Cantos, Blanca, Núñez, Beatriz, Sousa, Pedro A. C., Provencio, Mariano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/148293
Resumo: Funding Information: This article is part of the CLARIFY project, supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement number 875160. Publisher Copyright: Copyright © 2022 Torrente, Blanco, Franco, Garitaonaindia, Calvo, Collazo-Lorduy, Gutiérrez, Sánchez, González-del-Alba, Hernández, Méndez, Cantos, Núñez, Sousa and Provencio.
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spelling Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitorscardiotoxicitycardiovascular eventimmune checkpoint inhibitorsmyocarditisrisk factorsCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingFunding Information: This article is part of the CLARIFY project, supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement number 875160. Publisher Copyright: Copyright © 2022 Torrente, Blanco, Franco, Garitaonaindia, Calvo, Collazo-Lorduy, Gutiérrez, Sánchez, González-del-Alba, Hernández, Méndez, Cantos, Núñez, Sousa and Provencio.Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, despite their excellent therapeutic effect, these medications typically result in a broad spectrum of toxicity reactions. Immune-related cardiotoxicity is uncommon but can be potentially fatal, and its true incidence is underestimated in clinical trials. The aim of this study is to assess the incidence and identify risk factors for developing a cardiac event in patients treated with ICIs. Methods: We conducted a single-institution retrospective study, including patients treated with ICIs in our center. The main outcomes were cardiac events (CE) and cardiovascular death. Results: A total of 378 patients were analyzed. The incidence of CE was 16.7%, during a median follow-up of 50.5 months. The multivariable analysis showed that age, a history of arrhythmia or ischemic heart disease, and prior immune-related adverse events were significantly associated with CE. Conclusion: CE during ICI treatment are more common than currently appreciated. A complete initial cardiovascular evaluation is recommended, especially in high-risk patients, being necessary a multidisciplinary approach of a specialized cardio-oncology team.DEE - Departamento de Engenharia Electrotécnica e de ComputadoresRUNTorrente, MaríaBlanco, MariolaFranco, FabioGaritaonaindia, YagoCalvo, VirginiaCollazo-Lorduy, AnaGutiérrez, LourdesSánchez, Juan CristóbalGonzález-del-Alba, AranzazuHernández, RobertoMéndez, MiriamCantos, BlancaNúñez, BeatrizSousa, Pedro A. C.Provencio, Mariano2023-01-27T22:20:13Z2022-12-012022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/148293eng2297-055XPURE: 51567363https://doi.org/10.3389/fcvm.2022.1062858info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:43Zoai:run.unl.pt:10362/148293Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:19.048789Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
title Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
spellingShingle Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
Torrente, María
cardiotoxicity
cardiovascular event
immune checkpoint inhibitors
myocarditis
risk factors
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
title_short Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
title_full Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
title_fullStr Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
title_full_unstemmed Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
title_sort Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors
author Torrente, María
author_facet Torrente, María
Blanco, Mariola
Franco, Fabio
Garitaonaindia, Yago
Calvo, Virginia
Collazo-Lorduy, Ana
Gutiérrez, Lourdes
Sánchez, Juan Cristóbal
González-del-Alba, Aranzazu
Hernández, Roberto
Méndez, Miriam
Cantos, Blanca
Núñez, Beatriz
Sousa, Pedro A. C.
Provencio, Mariano
author_role author
author2 Blanco, Mariola
Franco, Fabio
Garitaonaindia, Yago
Calvo, Virginia
Collazo-Lorduy, Ana
Gutiérrez, Lourdes
Sánchez, Juan Cristóbal
González-del-Alba, Aranzazu
Hernández, Roberto
Méndez, Miriam
Cantos, Blanca
Núñez, Beatriz
Sousa, Pedro A. C.
Provencio, Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DEE - Departamento de Engenharia Electrotécnica e de Computadores
RUN
dc.contributor.author.fl_str_mv Torrente, María
Blanco, Mariola
Franco, Fabio
Garitaonaindia, Yago
Calvo, Virginia
Collazo-Lorduy, Ana
Gutiérrez, Lourdes
Sánchez, Juan Cristóbal
González-del-Alba, Aranzazu
Hernández, Roberto
Méndez, Miriam
Cantos, Blanca
Núñez, Beatriz
Sousa, Pedro A. C.
Provencio, Mariano
dc.subject.por.fl_str_mv cardiotoxicity
cardiovascular event
immune checkpoint inhibitors
myocarditis
risk factors
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
topic cardiotoxicity
cardiovascular event
immune checkpoint inhibitors
myocarditis
risk factors
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
description Funding Information: This article is part of the CLARIFY project, supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement number 875160. Publisher Copyright: Copyright © 2022 Torrente, Blanco, Franco, Garitaonaindia, Calvo, Collazo-Lorduy, Gutiérrez, Sánchez, González-del-Alba, Hernández, Méndez, Cantos, Núñez, Sousa and Provencio.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-01
2022-12-01T00:00:00Z
2023-01-27T22:20:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/148293
url http://hdl.handle.net/10362/148293
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2297-055X
PURE: 51567363
https://doi.org/10.3389/fcvm.2022.1062858
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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