Limited host availability disrupts the genetic correlation between virulence and transmission

Detalhes bibliográficos
Autor(a) principal: Godinho, Diogo
Data de Publicação: 2023
Outros Autores: Rodrigues, Leonor R, Lefevre, Sophie, Delteil, Laurane, Mira, André, De mendonça fragata almeida, Inês, Magalhães, sara, Duncan, Alison
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58348
Resumo: Virulence is expected to be linked to parasite fitness via transmission. However, it is not clear whether this relationship is genetically determined, nor if it differs when transmission occurs continuously during, or only at the end of, the infection period. Here, we used inbred lines of the macroparasitic spider mite Tetranychus urticae to disentangle genetic vs. nongenetic correlations among traits, while varying parasite density and opportunities for transmission. A positive genetic correlation between virulence and the number of transmitting stages produced was found under continuous transmission. However, if transmission occurred only at the end of the infection period, this genetic correlation disappeared. Instead, we observed a negative relationship between virulence and the num ber of transmitting stages, driven by density dependence. Thus, within-host density dependence caused by reduced opportunities for transmission may hamper selection for higher virulence, providing a novel explanation as to why limited host availability leads to lower virulence
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spelling Limited host availability disrupts the genetic correlation between virulence and transmissionVirulence is expected to be linked to parasite fitness via transmission. However, it is not clear whether this relationship is genetically determined, nor if it differs when transmission occurs continuously during, or only at the end of, the infection period. Here, we used inbred lines of the macroparasitic spider mite Tetranychus urticae to disentangle genetic vs. nongenetic correlations among traits, while varying parasite density and opportunities for transmission. A positive genetic correlation between virulence and the number of transmitting stages produced was found under continuous transmission. However, if transmission occurred only at the end of the infection period, this genetic correlation disappeared. Instead, we observed a negative relationship between virulence and the num ber of transmitting stages, driven by density dependence. Thus, within-host density dependence caused by reduced opportunities for transmission may hamper selection for higher virulence, providing a novel explanation as to why limited host availability leads to lower virulenceOxford University PressRepositório da Universidade de LisboaGodinho, DiogoRodrigues, Leonor RLefevre, SophieDelteil, LauraneMira, AndréDe mendonça fragata almeida, InêsMagalhães, saraDuncan, Alison2023-06-27T14:51:18Z2023-012023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58348engGodinho DP, Rodrigues LR, Lefèvre S, Delteil L, Mira AF, Fragata IR, Magalhães S, Duncan AB. Limited host availability disrupts the genetic correlation between virulence and transmission. Evol Lett. 2023 Jan 31;7(1):58-66. doi: 10.1093/evlett/qrac008. PMID: 37065437; PMCID: PMC10091498.10.1093/evlett/qrac008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:07:10Zoai:repositorio.ul.pt:10451/58348Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:38.598569Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Limited host availability disrupts the genetic correlation between virulence and transmission
title Limited host availability disrupts the genetic correlation between virulence and transmission
spellingShingle Limited host availability disrupts the genetic correlation between virulence and transmission
Godinho, Diogo
title_short Limited host availability disrupts the genetic correlation between virulence and transmission
title_full Limited host availability disrupts the genetic correlation between virulence and transmission
title_fullStr Limited host availability disrupts the genetic correlation between virulence and transmission
title_full_unstemmed Limited host availability disrupts the genetic correlation between virulence and transmission
title_sort Limited host availability disrupts the genetic correlation between virulence and transmission
author Godinho, Diogo
author_facet Godinho, Diogo
Rodrigues, Leonor R
Lefevre, Sophie
Delteil, Laurane
Mira, André
De mendonça fragata almeida, Inês
Magalhães, sara
Duncan, Alison
author_role author
author2 Rodrigues, Leonor R
Lefevre, Sophie
Delteil, Laurane
Mira, André
De mendonça fragata almeida, Inês
Magalhães, sara
Duncan, Alison
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Godinho, Diogo
Rodrigues, Leonor R
Lefevre, Sophie
Delteil, Laurane
Mira, André
De mendonça fragata almeida, Inês
Magalhães, sara
Duncan, Alison
description Virulence is expected to be linked to parasite fitness via transmission. However, it is not clear whether this relationship is genetically determined, nor if it differs when transmission occurs continuously during, or only at the end of, the infection period. Here, we used inbred lines of the macroparasitic spider mite Tetranychus urticae to disentangle genetic vs. nongenetic correlations among traits, while varying parasite density and opportunities for transmission. A positive genetic correlation between virulence and the number of transmitting stages produced was found under continuous transmission. However, if transmission occurred only at the end of the infection period, this genetic correlation disappeared. Instead, we observed a negative relationship between virulence and the num ber of transmitting stages, driven by density dependence. Thus, within-host density dependence caused by reduced opportunities for transmission may hamper selection for higher virulence, providing a novel explanation as to why limited host availability leads to lower virulence
publishDate 2023
dc.date.none.fl_str_mv 2023-06-27T14:51:18Z
2023-01
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58348
url http://hdl.handle.net/10451/58348
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Godinho DP, Rodrigues LR, Lefèvre S, Delteil L, Mira AF, Fragata IR, Magalhães S, Duncan AB. Limited host availability disrupts the genetic correlation between virulence and transmission. Evol Lett. 2023 Jan 31;7(1):58-66. doi: 10.1093/evlett/qrac008. PMID: 37065437; PMCID: PMC10091498.
10.1093/evlett/qrac008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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