Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/7919 |
Resumo: | Objective: The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement among 4 cytology laboratories participating in the LAMS Study. Study Design: The study was an interlaboratory exchange of specially designed 5 slide sets, each comprising 20 (conventional cytology) slides. At the first step, 80 slides (with "clear-cut" cases) were divided into four sets (A, B, C, D) of 20 specimens, each including inadequate and negative cases as well as in different proportions of all diagnostic TBS 2001 categories. In the second round, a fifth set (E) of 20 slides ("difficult cases") was designed, with all diagnostic categories, ASC and AGC included. Common measures of reproducibility (? and weighted ?), accuracy (SE, SP, PPV, NPV) and 3 indices of diagnostic variability were calculated for sets A-D and set E, separately. Results: For the 5 slide sets together, the weighted ? was 0.8 (95% CI 0.76-0.85), which is the lower limit of the "almost perfect" ranking of ? statistics, indicating an excellent interlaboratory agreement. The interlaboratory reproducibility was lower only for the difficult set (E). Similarly, the sensitivity for set E (70.0%) was lower than that (92.1%) for sets A-D. The diagnostic variability indices were not substantially different between the difficult (set E) and clear-cut (sets A-D) cases. Conclusion: High interlaboratory reproducibility was obtained for sets A-D ("clear-cut" cases), while more interlaboratory variation was evident in the difficult samples. The new CONQUISTADOR software is a valuable tool in calculating the indicators needed in this intralaboratory and interlaboratory QC. © The International Academy of Cytology. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening studyDiagnostic accuracy indexKappaQuality controlPap smearPerformance indicatorsReproducibilitySoftwareScience & TechnologyObjective: The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement among 4 cytology laboratories participating in the LAMS Study. Study Design: The study was an interlaboratory exchange of specially designed 5 slide sets, each comprising 20 (conventional cytology) slides. At the first step, 80 slides (with "clear-cut" cases) were divided into four sets (A, B, C, D) of 20 specimens, each including inadequate and negative cases as well as in different proportions of all diagnostic TBS 2001 categories. In the second round, a fifth set (E) of 20 slides ("difficult cases") was designed, with all diagnostic categories, ASC and AGC included. Common measures of reproducibility (? and weighted ?), accuracy (SE, SP, PPV, NPV) and 3 indices of diagnostic variability were calculated for sets A-D and set E, separately. Results: For the 5 slide sets together, the weighted ? was 0.8 (95% CI 0.76-0.85), which is the lower limit of the "almost perfect" ranking of ? statistics, indicating an excellent interlaboratory agreement. The interlaboratory reproducibility was lower only for the difficult set (E). Similarly, the sensitivity for set E (70.0%) was lower than that (92.1%) for sets A-D. The diagnostic variability indices were not substantially different between the difficult (set E) and clear-cut (sets A-D) cases. Conclusion: High interlaboratory reproducibility was obtained for sets A-D ("clear-cut" cases), while more interlaboratory variation was evident in the difficult samples. The new CONQUISTADOR software is a valuable tool in calculating the indicators needed in this intralaboratory and interlaboratory QC. © The International Academy of Cytology.European Commission - INCO-DEV Programme Contract ICA4-CT-2001-10013Learning Activity Management System (LAMS)Karger PublishersUniversidade do MinhoAlderisio, M.Branca, M.Eržen, M.Longatto Filho, AdhemarDerchain, S. F.Tatti, S.Vighi, S.Roteli-Martins, C.Leoncini, L.Maeda, Marina Yoshiê SakamotoMontis, D. M.Gontijo, R.Sarian, L. O.Syrjänen, K.2007-112007-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/7919eng"Acta Cytologica". ISSN 0001-5547. 51:6 (Nov. 2007) 872–881.0001-554710.1159/000325863http://www.acta-cytol.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:55Zoai:repositorium.sdum.uminho.pt:1822/7919Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:04.568757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
title |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
spellingShingle |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study Alderisio, M. Diagnostic accuracy index Kappa Quality control Pap smear Performance indicators Reproducibility Software Science & Technology |
title_short |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
title_full |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
title_fullStr |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
title_full_unstemmed |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
title_sort |
Interlaboratory quality control in gynecologic cytopathology using the novel conquistador software : interobserver reproducibility in the Latin American screening study |
author |
Alderisio, M. |
author_facet |
Alderisio, M. Branca, M. Eržen, M. Longatto Filho, Adhemar Derchain, S. F. Tatti, S. Vighi, S. Roteli-Martins, C. Leoncini, L. Maeda, Marina Yoshiê Sakamoto Montis, D. M. Gontijo, R. Sarian, L. O. Syrjänen, K. |
author_role |
author |
author2 |
Branca, M. Eržen, M. Longatto Filho, Adhemar Derchain, S. F. Tatti, S. Vighi, S. Roteli-Martins, C. Leoncini, L. Maeda, Marina Yoshiê Sakamoto Montis, D. M. Gontijo, R. Sarian, L. O. Syrjänen, K. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Alderisio, M. Branca, M. Eržen, M. Longatto Filho, Adhemar Derchain, S. F. Tatti, S. Vighi, S. Roteli-Martins, C. Leoncini, L. Maeda, Marina Yoshiê Sakamoto Montis, D. M. Gontijo, R. Sarian, L. O. Syrjänen, K. |
dc.subject.por.fl_str_mv |
Diagnostic accuracy index Kappa Quality control Pap smear Performance indicators Reproducibility Software Science & Technology |
topic |
Diagnostic accuracy index Kappa Quality control Pap smear Performance indicators Reproducibility Software Science & Technology |
description |
Objective: The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement among 4 cytology laboratories participating in the LAMS Study. Study Design: The study was an interlaboratory exchange of specially designed 5 slide sets, each comprising 20 (conventional cytology) slides. At the first step, 80 slides (with "clear-cut" cases) were divided into four sets (A, B, C, D) of 20 specimens, each including inadequate and negative cases as well as in different proportions of all diagnostic TBS 2001 categories. In the second round, a fifth set (E) of 20 slides ("difficult cases") was designed, with all diagnostic categories, ASC and AGC included. Common measures of reproducibility (? and weighted ?), accuracy (SE, SP, PPV, NPV) and 3 indices of diagnostic variability were calculated for sets A-D and set E, separately. Results: For the 5 slide sets together, the weighted ? was 0.8 (95% CI 0.76-0.85), which is the lower limit of the "almost perfect" ranking of ? statistics, indicating an excellent interlaboratory agreement. The interlaboratory reproducibility was lower only for the difficult set (E). Similarly, the sensitivity for set E (70.0%) was lower than that (92.1%) for sets A-D. The diagnostic variability indices were not substantially different between the difficult (set E) and clear-cut (sets A-D) cases. Conclusion: High interlaboratory reproducibility was obtained for sets A-D ("clear-cut" cases), while more interlaboratory variation was evident in the difficult samples. The new CONQUISTADOR software is a valuable tool in calculating the indicators needed in this intralaboratory and interlaboratory QC. © The International Academy of Cytology. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-11 2007-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/7919 |
url |
http://hdl.handle.net/1822/7919 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Acta Cytologica". ISSN 0001-5547. 51:6 (Nov. 2007) 872–881. 0001-5547 10.1159/000325863 http://www.acta-cytol.com/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger Publishers |
publisher.none.fl_str_mv |
Karger Publishers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132581960089600 |