Effects of the ketogenic diet in the treatment of gliomas: a systematic review

Bibliographic Details
Main Author: Sargaço, Beatriz
Publication Date: 2022
Other Authors: Oliveira, Patrícia, Antunes, Maria Da Luz, Moreira, Ana Catarina
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10400.21/14346
Summary: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Effects of the ketogenic diet in the treatment of gliomas: a systematic reviewNutritionDieteticsKetogenic dietGliomaGlioblastomaSurvivalFCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet stimulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft® Excel® was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life.MDPIRCIPLSargaço, BeatrizOliveira, PatríciaAntunes, Maria Da LuzMoreira, Ana Catarina2022-02-28T12:33:30Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14346engSargaço B, Oliveira PA, Antunes ML, Moreira AC. Effects of the ketogenic diet in the treatment of gliomas: a systematic review. Nutrients. 2022;14(5):1007.10.3390/nu14051007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:23Zoai:repositorio.ipl.pt:10400.21/14346Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:10.047700Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of the ketogenic diet in the treatment of gliomas: a systematic review
title Effects of the ketogenic diet in the treatment of gliomas: a systematic review
spellingShingle Effects of the ketogenic diet in the treatment of gliomas: a systematic review
Sargaço, Beatriz
Nutrition
Dietetics
Ketogenic diet
Glioma
Glioblastoma
Survival
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Effects of the ketogenic diet in the treatment of gliomas: a systematic review
title_full Effects of the ketogenic diet in the treatment of gliomas: a systematic review
title_fullStr Effects of the ketogenic diet in the treatment of gliomas: a systematic review
title_full_unstemmed Effects of the ketogenic diet in the treatment of gliomas: a systematic review
title_sort Effects of the ketogenic diet in the treatment of gliomas: a systematic review
author Sargaço, Beatriz
author_facet Sargaço, Beatriz
Oliveira, Patrícia
Antunes, Maria Da Luz
Moreira, Ana Catarina
author_role author
author2 Oliveira, Patrícia
Antunes, Maria Da Luz
Moreira, Ana Catarina
author2_role author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Sargaço, Beatriz
Oliveira, Patrícia
Antunes, Maria Da Luz
Moreira, Ana Catarina
dc.subject.por.fl_str_mv Nutrition
Dietetics
Ketogenic diet
Glioma
Glioblastoma
Survival
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Nutrition
Dietetics
Ketogenic diet
Glioma
Glioblastoma
Survival
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-28T12:33:30Z
2022-02
2022-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14346
url http://hdl.handle.net/10400.21/14346
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sargaço B, Oliveira PA, Antunes ML, Moreira AC. Effects of the ketogenic diet in the treatment of gliomas: a systematic review. Nutrients. 2022;14(5):1007.
10.3390/nu14051007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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