Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/157227 |
Resumo: | Funding Information: This work was supported, in part, by the Bill and Melinda Gates Foundation, through PATH subaward number: GAT.2111-01707508-SUB. Under the grant conditions of the foundation, a Creative Commons Attribution 4.0 generic license has already been assigned to the author accepted manuscript version that might arise from this submission. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill and Melinda Gates Foundation. Publisher Copyright: © 2023 by the authors. |
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Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in MozambiqueA Modelling Studycervical cancercost-effectivenessmodellingMozambiquepapillomavirusUNIVACvaccinationQR180 ImmunologyRJ101 Child Health. Child health servicesRC0254 Neoplasms. Tumors. Oncology (including Cancer)RM Therapeutics. PharmacologyImmunologyPharmacologyDrug DiscoveryInfectious DiseasesPharmacology (medical)Pediatrics, Perinatology, and Child HealthSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesFunding Information: This work was supported, in part, by the Bill and Melinda Gates Foundation, through PATH subaward number: GAT.2111-01707508-SUB. Under the grant conditions of the foundation, a Creative Commons Attribution 4.0 generic license has already been assigned to the author accepted manuscript version that might arise from this submission. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill and Melinda Gates Foundation. Publisher Copyright: © 2023 by the authors.Mozambique has one of the highest rates of cervical cancer in the world. Human papillomavirus (HPV) vaccination was introduced in 2021. This study evaluated the health and economic impact of the current HPV vaccine (GARDASIL® hereafter referred to as GARDASIL-4) and two other vaccines (CECOLIN® and CERVARIX®) that could be used in the future. A static cohort model was used to estimate the costs and benefits of vaccinating girls in Mozambique over the period 2022–2031. The primary outcome measure was the incremental cost per disability-adjusted life-year averted from a government perspective. We conducted deterministic and probabilistic sensitivity analyses. Without cross-protection, all three vaccines averted approximately 54% cervical cancer cases and deaths. With cross-protection, CERVARIX averted 70% of cases and deaths. Without Gavi support, the discounted vaccine program costs ranged from 60 million to 81 million USD. Vaccine program costs were approximately 37 million USD for all vaccines with Gavi support. Without cross-protection, CECOLIN was dominant, being cost-effective with or without Gavi support. With cross-protection and Gavi support, CERVARIX was dominant and cost-saving. With cross-protection and no Gavi support, CECOLIN had the most favorable cost-effectiveness ratio. Conclusions: At a willingness-to-pay (WTP) threshold set at 35% of Gross Domestic Product (GDP) per capita, HPV vaccination is cost-effective in Mozambique. The optimal vaccine choice depends on cross-protection assumptions.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Population health, policies and services (PPS)RUNGuimarães, Esperança LourençoChissaque, AssucênioPecenka, ClintDebellut, FrédéricSchuind, AnneVaz, BasíliaBanze, ArlindoRangeiro, RicardinaMariano, ArleteLorenzoni, CesaltinaCarrilho, CarlaMartins, Maria do Rosário Oliveirade Deus, NilsaClark, Andrew2023-09-01T22:16:05Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/157227eng2076-393XPURE: 70443083https://doi.org/10.3390/vaccines11061058info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:39:32Zoai:run.unl.pt:10362/157227Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:37.788004Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique A Modelling Study |
| title |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| spellingShingle |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique Guimarães, Esperança Lourenço cervical cancer cost-effectiveness modelling Mozambique papillomavirus UNIVAC vaccination QR180 Immunology RJ101 Child Health. Child health services RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) Pediatrics, Perinatology, and Child Health SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| title_short |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| title_full |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| title_fullStr |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| title_full_unstemmed |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| title_sort |
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique |
| author |
Guimarães, Esperança Lourenço |
| author_facet |
Guimarães, Esperança Lourenço Chissaque, Assucênio Pecenka, Clint Debellut, Frédéric Schuind, Anne Vaz, Basília Banze, Arlindo Rangeiro, Ricardina Mariano, Arlete Lorenzoni, Cesaltina Carrilho, Carla Martins, Maria do Rosário Oliveira de Deus, Nilsa Clark, Andrew |
| author_role |
author |
| author2 |
Chissaque, Assucênio Pecenka, Clint Debellut, Frédéric Schuind, Anne Vaz, Basília Banze, Arlindo Rangeiro, Ricardina Mariano, Arlete Lorenzoni, Cesaltina Carrilho, Carla Martins, Maria do Rosário Oliveira de Deus, Nilsa Clark, Andrew |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Population health, policies and services (PPS) RUN |
| dc.contributor.author.fl_str_mv |
Guimarães, Esperança Lourenço Chissaque, Assucênio Pecenka, Clint Debellut, Frédéric Schuind, Anne Vaz, Basília Banze, Arlindo Rangeiro, Ricardina Mariano, Arlete Lorenzoni, Cesaltina Carrilho, Carla Martins, Maria do Rosário Oliveira de Deus, Nilsa Clark, Andrew |
| dc.subject.por.fl_str_mv |
cervical cancer cost-effectiveness modelling Mozambique papillomavirus UNIVAC vaccination QR180 Immunology RJ101 Child Health. Child health services RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) Pediatrics, Perinatology, and Child Health SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| topic |
cervical cancer cost-effectiveness modelling Mozambique papillomavirus UNIVAC vaccination QR180 Immunology RJ101 Child Health. Child health services RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) Pediatrics, Perinatology, and Child Health SDG 3 - Good Health and Well-being SDG 10 - Reduced Inequalities |
| description |
Funding Information: This work was supported, in part, by the Bill and Melinda Gates Foundation, through PATH subaward number: GAT.2111-01707508-SUB. Under the grant conditions of the foundation, a Creative Commons Attribution 4.0 generic license has already been assigned to the author accepted manuscript version that might arise from this submission. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill and Melinda Gates Foundation. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-01T22:16:05Z 2023-06 2023-06-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/157227 |
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http://hdl.handle.net/10362/157227 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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2076-393X PURE: 70443083 https://doi.org/10.3390/vaccines11061058 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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16 application/pdf |
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