Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109298 https://doi.org/10.5935/0100-4042.20150056 |
Resumo: | Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media. |
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Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micellesaluminum phthalocyanine chloridepolymeric micellesself-aggregationphotodynamic therapyAluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media.Sociedade Brasileira de Quimica2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109298http://hdl.handle.net/10316/109298https://doi.org/10.5935/0100-4042.20150056eng0100-4042Vilsinski, Bruno H.Gerola, Adriana P.Lemos, Évelin O.Barbosa, Patrícia M.Campanholi, Katieli S. S.César, Gabriel B.Tessaro, André L.Hioka, NoboruCaetano, Wilkerinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-09T10:25:38Zoai:estudogeral.uc.pt:10316/109298Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:30.369388Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
title |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
spellingShingle |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles Vilsinski, Bruno H. aluminum phthalocyanine chloride polymeric micelles self-aggregation photodynamic therapy |
title_short |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
title_full |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
title_fullStr |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
title_full_unstemmed |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
title_sort |
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles |
author |
Vilsinski, Bruno H. |
author_facet |
Vilsinski, Bruno H. Gerola, Adriana P. Lemos, Évelin O. Barbosa, Patrícia M. Campanholi, Katieli S. S. César, Gabriel B. Tessaro, André L. Hioka, Noboru Caetano, Wilker |
author_role |
author |
author2 |
Gerola, Adriana P. Lemos, Évelin O. Barbosa, Patrícia M. Campanholi, Katieli S. S. César, Gabriel B. Tessaro, André L. Hioka, Noboru Caetano, Wilker |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vilsinski, Bruno H. Gerola, Adriana P. Lemos, Évelin O. Barbosa, Patrícia M. Campanholi, Katieli S. S. César, Gabriel B. Tessaro, André L. Hioka, Noboru Caetano, Wilker |
dc.subject.por.fl_str_mv |
aluminum phthalocyanine chloride polymeric micelles self-aggregation photodynamic therapy |
topic |
aluminum phthalocyanine chloride polymeric micelles self-aggregation photodynamic therapy |
description |
Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109298 http://hdl.handle.net/10316/109298 https://doi.org/10.5935/0100-4042.20150056 |
url |
http://hdl.handle.net/10316/109298 https://doi.org/10.5935/0100-4042.20150056 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0100-4042 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Quimica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Quimica |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134137501614080 |