Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

Detalhes bibliográficos
Autor(a) principal: Dioli, Chrysoula
Data de Publicação: 2017
Outros Autores: Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., Ferreiro, E., Borges, S., Mateus-Pinheiro, A., Rodrigues, A. J., Sousa, Nuno, Peixoto, João Miguel Seiça Bessa, Pinto, Luísa, Sotiropoulos, I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/51555
Resumo: uncorrected proof
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spelling Tau-dependent suppression of adult neurogenesis in the stressed hippocampusCiências Médicas::Medicina ClínicaScience & Technologyuncorrected proofStress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain.Portuguese Foundation for Science and Technology (FCT) Investigator grants (IF/01799/2013, IF/00883/2013, IF/01079/2014, respectively). This work was funded by FCT research grants 'PTDC/SAU-NMC/113934/2009' (IS), the Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), the Project Estratégico co-funded by FCT (PEst-C/SAU/LA0026/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298) as well as the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER)info:eu-repo/semantics/publishedVersionNature Publishing GroupUniversidade do MinhoDioli, ChrysoulaPatrício, P.Trindade, R.Pinto, L. G.Silva, J. M.Morais, M.Ferreiro, E.Borges, S.Mateus-Pinheiro, A.Rodrigues, A. J.Sousa, NunoPeixoto, João Miguel Seiça BessaPinto, LuísaSotiropoulos, I.2017-05-282017-05-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/51555engDioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., ... & Sousa, N. (2017). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry, 22(8), 11101359-418410.1038/mp.2017.10328555078https://www.nature.com/articles/mp2017103info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:01Zoai:repositorium.sdum.uminho.pt:1822/51555Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:50:56.187902Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
title Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
spellingShingle Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
Dioli, Chrysoula
Ciências Médicas::Medicina Clínica
Science & Technology
title_short Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
title_full Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
title_fullStr Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
title_full_unstemmed Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
title_sort Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
author Dioli, Chrysoula
author_facet Dioli, Chrysoula
Patrício, P.
Trindade, R.
Pinto, L. G.
Silva, J. M.
Morais, M.
Ferreiro, E.
Borges, S.
Mateus-Pinheiro, A.
Rodrigues, A. J.
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Pinto, Luísa
Sotiropoulos, I.
author_role author
author2 Patrício, P.
Trindade, R.
Pinto, L. G.
Silva, J. M.
Morais, M.
Ferreiro, E.
Borges, S.
Mateus-Pinheiro, A.
Rodrigues, A. J.
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Pinto, Luísa
Sotiropoulos, I.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Dioli, Chrysoula
Patrício, P.
Trindade, R.
Pinto, L. G.
Silva, J. M.
Morais, M.
Ferreiro, E.
Borges, S.
Mateus-Pinheiro, A.
Rodrigues, A. J.
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Pinto, Luísa
Sotiropoulos, I.
dc.subject.por.fl_str_mv Ciências Médicas::Medicina Clínica
Science & Technology
topic Ciências Médicas::Medicina Clínica
Science & Technology
description uncorrected proof
publishDate 2017
dc.date.none.fl_str_mv 2017-05-28
2017-05-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/51555
url http://hdl.handle.net/1822/51555
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., ... & Sousa, N. (2017). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry, 22(8), 1110
1359-4184
10.1038/mp.2017.103
28555078
https://www.nature.com/articles/mp2017103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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