Integrated biomimetic carbon nanotube composites for in vivo systems
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/5042 |
Resumo: | As interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and chemical characteristics. Here, we demonstrate the highly successful capacity for in vivo implantation of a new carbon nanotube-based composite that is, itself, integrated with a hydroxyapatite-polymethyl methacrylate to create a nanocomposite. The success of this approach is grounded in finely tailoring the physical and chemical properties of this composite for the critical demands of biological integration. This is accomplished through controlling the surface modification scheme, which affects the interactions between carbon nanotubes and the hydroxyapatite-polymethyl methacrylate. Furthermore, we carefully examine cellular response with respect to adhesion and proliferation to examine in vitro compatibility capacity. Our results indicate that this new composite accelerates cell maturation through providing a mechanically competent bone matrix; this likely facilitates osteointegration in vivo. We believe that these results will have applications in a diversity of areas including carbon nanotube, regeneration, chemistry, and engineering research. |
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Integrated biomimetic carbon nanotube composites for in vivo systemsPMMACarbon-nanotube compositeHydroxyapatitein vivoin vitroOsteointegrationBiocompatibilityBone cementAs interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and chemical characteristics. Here, we demonstrate the highly successful capacity for in vivo implantation of a new carbon nanotube-based composite that is, itself, integrated with a hydroxyapatite-polymethyl methacrylate to create a nanocomposite. The success of this approach is grounded in finely tailoring the physical and chemical properties of this composite for the critical demands of biological integration. This is accomplished through controlling the surface modification scheme, which affects the interactions between carbon nanotubes and the hydroxyapatite-polymethyl methacrylate. Furthermore, we carefully examine cellular response with respect to adhesion and proliferation to examine in vitro compatibility capacity. Our results indicate that this new composite accelerates cell maturation through providing a mechanically competent bone matrix; this likely facilitates osteointegration in vivo. We believe that these results will have applications in a diversity of areas including carbon nanotube, regeneration, chemistry, and engineering research.The Royal Society of Chemistry2012-01-11T12:13:49Z2010-11-01T00:00:00Z2010-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/5042eng2040-3364Singh, Manoj KumarGracio, JoseLeDuc, PhilipGonçalves, Paula P.Marques, Paula A. A. P.Gonçalves, GilMarques, FilipaSilva, Virgilia S.Capela e Silva, FernandoReis, JoanaPotes, JoseSousa, Antónioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:06:24Zoai:ria.ua.pt:10773/5042Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:42:53.615298Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Integrated biomimetic carbon nanotube composites for in vivo systems |
title |
Integrated biomimetic carbon nanotube composites for in vivo systems |
spellingShingle |
Integrated biomimetic carbon nanotube composites for in vivo systems Singh, Manoj Kumar PMMA Carbon-nanotube composite Hydroxyapatite in vivo in vitro Osteointegration Biocompatibility Bone cement |
title_short |
Integrated biomimetic carbon nanotube composites for in vivo systems |
title_full |
Integrated biomimetic carbon nanotube composites for in vivo systems |
title_fullStr |
Integrated biomimetic carbon nanotube composites for in vivo systems |
title_full_unstemmed |
Integrated biomimetic carbon nanotube composites for in vivo systems |
title_sort |
Integrated biomimetic carbon nanotube composites for in vivo systems |
author |
Singh, Manoj Kumar |
author_facet |
Singh, Manoj Kumar Gracio, Jose LeDuc, Philip Gonçalves, Paula P. Marques, Paula A. A. P. Gonçalves, Gil Marques, Filipa Silva, Virgilia S. Capela e Silva, Fernando Reis, Joana Potes, Jose Sousa, António |
author_role |
author |
author2 |
Gracio, Jose LeDuc, Philip Gonçalves, Paula P. Marques, Paula A. A. P. Gonçalves, Gil Marques, Filipa Silva, Virgilia S. Capela e Silva, Fernando Reis, Joana Potes, Jose Sousa, António |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Singh, Manoj Kumar Gracio, Jose LeDuc, Philip Gonçalves, Paula P. Marques, Paula A. A. P. Gonçalves, Gil Marques, Filipa Silva, Virgilia S. Capela e Silva, Fernando Reis, Joana Potes, Jose Sousa, António |
dc.subject.por.fl_str_mv |
PMMA Carbon-nanotube composite Hydroxyapatite in vivo in vitro Osteointegration Biocompatibility Bone cement |
topic |
PMMA Carbon-nanotube composite Hydroxyapatite in vivo in vitro Osteointegration Biocompatibility Bone cement |
description |
As interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and chemical characteristics. Here, we demonstrate the highly successful capacity for in vivo implantation of a new carbon nanotube-based composite that is, itself, integrated with a hydroxyapatite-polymethyl methacrylate to create a nanocomposite. The success of this approach is grounded in finely tailoring the physical and chemical properties of this composite for the critical demands of biological integration. This is accomplished through controlling the surface modification scheme, which affects the interactions between carbon nanotubes and the hydroxyapatite-polymethyl methacrylate. Furthermore, we carefully examine cellular response with respect to adhesion and proliferation to examine in vitro compatibility capacity. Our results indicate that this new composite accelerates cell maturation through providing a mechanically competent bone matrix; this likely facilitates osteointegration in vivo. We believe that these results will have applications in a diversity of areas including carbon nanotube, regeneration, chemistry, and engineering research. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-11-01T00:00:00Z 2010-11 2012-01-11T12:13:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/5042 |
url |
http://hdl.handle.net/10773/5042 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2040-3364 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
The Royal Society of Chemistry |
publisher.none.fl_str_mv |
The Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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