Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/15080 |
Resumo: | Objective and design: The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods: PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed RESULTS: Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies were listed after the exclusion of duplicates, and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites such as the aminoacid L-tyrosine and the lipidic compound 2-monolinolenin. Conclusion: This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, which contributes as a basis for choosing compounds and directing further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic. |
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Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping reviewACE-IICoronavirusSecondary metaboliteTreatmentObjective and design: The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods: PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed RESULTS: Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies were listed after the exclusion of duplicates, and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites such as the aminoacid L-tyrosine and the lipidic compound 2-monolinolenin. Conclusion: This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, which contributes as a basis for choosing compounds and directing further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic.Springer NatureRCIPLMatos, Pedro Henrique deSilva, Thalita Prates daMansano, Amanda BenitesGancedo, Naiara CássiaTonin, FernandaPelloso, Fernando CastilhoPetruco, Marcus ViniciusMelo, Eduardo Borges deFernandez-Llimos, FernandoSanches, Andreia Cristina ConegeroMello, João Carlos Palazzo deChierrito, DaniellyAraújo, Daniela Cristina de Medeiros2022-11-08T17:10:42Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/15080engMatos PH, Silva TP, Mansano AB, Gancedo NC, Tonin FS, Castilho Pelloso F, et al. Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review. Inflamm Res. 2022;71(12):1489-500.10.1007/s00011-022-01642-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:12:09Zoai:repositorio.ipl.pt:10400.21/15080Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:48.876708Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
title |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
spellingShingle |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review Matos, Pedro Henrique de ACE-II Coronavirus Secondary metabolite Treatment |
title_short |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
title_full |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
title_fullStr |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
title_full_unstemmed |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
title_sort |
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review |
author |
Matos, Pedro Henrique de |
author_facet |
Matos, Pedro Henrique de Silva, Thalita Prates da Mansano, Amanda Benites Gancedo, Naiara Cássia Tonin, Fernanda Pelloso, Fernando Castilho Petruco, Marcus Vinicius Melo, Eduardo Borges de Fernandez-Llimos, Fernando Sanches, Andreia Cristina Conegero Mello, João Carlos Palazzo de Chierrito, Danielly Araújo, Daniela Cristina de Medeiros |
author_role |
author |
author2 |
Silva, Thalita Prates da Mansano, Amanda Benites Gancedo, Naiara Cássia Tonin, Fernanda Pelloso, Fernando Castilho Petruco, Marcus Vinicius Melo, Eduardo Borges de Fernandez-Llimos, Fernando Sanches, Andreia Cristina Conegero Mello, João Carlos Palazzo de Chierrito, Danielly Araújo, Daniela Cristina de Medeiros |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Matos, Pedro Henrique de Silva, Thalita Prates da Mansano, Amanda Benites Gancedo, Naiara Cássia Tonin, Fernanda Pelloso, Fernando Castilho Petruco, Marcus Vinicius Melo, Eduardo Borges de Fernandez-Llimos, Fernando Sanches, Andreia Cristina Conegero Mello, João Carlos Palazzo de Chierrito, Danielly Araújo, Daniela Cristina de Medeiros |
dc.subject.por.fl_str_mv |
ACE-II Coronavirus Secondary metabolite Treatment |
topic |
ACE-II Coronavirus Secondary metabolite Treatment |
description |
Objective and design: The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods: PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed RESULTS: Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies were listed after the exclusion of duplicates, and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites such as the aminoacid L-tyrosine and the lipidic compound 2-monolinolenin. Conclusion: This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, which contributes as a basis for choosing compounds and directing further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-08T17:10:42Z 2022-12 2022-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/15080 |
url |
http://hdl.handle.net/10400.21/15080 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Matos PH, Silva TP, Mansano AB, Gancedo NC, Tonin FS, Castilho Pelloso F, et al. Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review. Inflamm Res. 2022;71(12):1489-500. 10.1007/s00011-022-01642-7 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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