Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method

Detalhes bibliográficos
Autor(a) principal: Ferro, Amadeu Borges
Data de Publicação: 2016
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/6257
Resumo: Immunohistochemistry (IHC) is the group of techniques that use antibodies as specific reagents to identify and demonstrate several cell and tissue components that are antigens. This linking allows locating and identifying the in situ presence of various substances by means of color that is associated with the formed antigen-antibody complexes. The practical value of this biotechnology area, widely used in Pathology and Oncology, in diagnostic, prognostic, theranostic and research context, results from the possibility of combining a colour marker with an antibody without causing any damage to specific binding established between antibody and antigen. This provides the microscopic observation of the target locations where the antibody and hence the antigen are present. IHC is presented as a powerful means for identification of several cellular and tissue structures that can be associated with pathologies, and of the consequences, at functional and morphological level, of these same elements action.
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spelling Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex methodImmunohistochemistryAntigen retrievalDetection systemImmunohistochemistry (IHC) is the group of techniques that use antibodies as specific reagents to identify and demonstrate several cell and tissue components that are antigens. This linking allows locating and identifying the in situ presence of various substances by means of color that is associated with the formed antigen-antibody complexes. The practical value of this biotechnology area, widely used in Pathology and Oncology, in diagnostic, prognostic, theranostic and research context, results from the possibility of combining a colour marker with an antibody without causing any damage to specific binding established between antibody and antigen. This provides the microscopic observation of the target locations where the antibody and hence the antigen are present. IHC is presented as a powerful means for identification of several cellular and tissue structures that can be associated with pathologies, and of the consequences, at functional and morphological level, of these same elements action.BioaccentRCIPLFerro, Amadeu Borges2016-06-29T14:50:40Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/6257engFerro AB. Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method. BAOJ Cancer Res Ther. 2016;2(5):22.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:50:50Zoai:repositorio.ipl.pt:10400.21/6257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:15:25.343436Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
title Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
spellingShingle Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
Ferro, Amadeu Borges
Immunohistochemistry
Antigen retrieval
Detection system
title_short Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
title_full Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
title_fullStr Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
title_full_unstemmed Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
title_sort Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method
author Ferro, Amadeu Borges
author_facet Ferro, Amadeu Borges
author_role author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Ferro, Amadeu Borges
dc.subject.por.fl_str_mv Immunohistochemistry
Antigen retrieval
Detection system
topic Immunohistochemistry
Antigen retrieval
Detection system
description Immunohistochemistry (IHC) is the group of techniques that use antibodies as specific reagents to identify and demonstrate several cell and tissue components that are antigens. This linking allows locating and identifying the in situ presence of various substances by means of color that is associated with the formed antigen-antibody complexes. The practical value of this biotechnology area, widely used in Pathology and Oncology, in diagnostic, prognostic, theranostic and research context, results from the possibility of combining a colour marker with an antibody without causing any damage to specific binding established between antibody and antigen. This provides the microscopic observation of the target locations where the antibody and hence the antigen are present. IHC is presented as a powerful means for identification of several cellular and tissue structures that can be associated with pathologies, and of the consequences, at functional and morphological level, of these same elements action.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-29T14:50:40Z
2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/6257
url http://hdl.handle.net/10400.21/6257
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ferro AB. Oncology research and clinical decisions based on immunohistochemistry: the importance of the technical aspects that support a complex method. BAOJ Cancer Res Ther. 2016;2(5):22.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bioaccent
publisher.none.fl_str_mv Bioaccent
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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