In vivo antioxidant activity of phenolic compounds: facts and gaps
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40244 |
Resumo: | Background: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research. Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin. Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided. Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce. |
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In vivo antioxidant activity of phenolic compounds: facts and gapsAging-related diseasesAntioxidant activityIn vivo studiesPhenolic extracts/compoundsBioavailabilityScience & TechnologyBackground: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research. Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin. Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided. Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce.The authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012), L. Barros researcher contract under "Programa Compromisso com Ciencia - 2008" and financial support to the research centre CIMO (strategic project Pest-OE/AGR/UI0690/2014).Elsevier B.V.Universidade do MinhoMartins, NatáliaBarros, LillianFerreira, Isabel C. F. R.2016-022016-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40244engMartins, N.; Barros, Lillian; Ferreira, Isabel C. F. R., In vivo antioxidant activity of phenolic compounds: facts and gaps. Trends in Food Science and Technology, 48, 1-12, 20160924-224410.1016/j.tifs.2015.11.008http://www.journals.elsevier.com/trends-in-food-science-and-technology/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:06:23ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
title |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
spellingShingle |
In vivo antioxidant activity of phenolic compounds: facts and gaps Martins, Natália Aging-related diseases Antioxidant activity In vivo studies Phenolic extracts/compounds Bioavailability Science & Technology |
title_short |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
title_full |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
title_fullStr |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
title_full_unstemmed |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
title_sort |
In vivo antioxidant activity of phenolic compounds: facts and gaps |
author |
Martins, Natália |
author_facet |
Martins, Natália Barros, Lillian Ferreira, Isabel C. F. R. |
author_role |
author |
author2 |
Barros, Lillian Ferreira, Isabel C. F. R. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Martins, Natália Barros, Lillian Ferreira, Isabel C. F. R. |
dc.subject.por.fl_str_mv |
Aging-related diseases Antioxidant activity In vivo studies Phenolic extracts/compounds Bioavailability Science & Technology |
topic |
Aging-related diseases Antioxidant activity In vivo studies Phenolic extracts/compounds Bioavailability Science & Technology |
description |
Background: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research. Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin. Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided. Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02 2016-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40244 |
url |
http://hdl.handle.net/1822/40244 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Martins, N.; Barros, Lillian; Ferreira, Isabel C. F. R., In vivo antioxidant activity of phenolic compounds: facts and gaps. Trends in Food Science and Technology, 48, 1-12, 2016 0924-2244 10.1016/j.tifs.2015.11.008 http://www.journals.elsevier.com/trends-in-food-science-and-technology/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303682724921344 |