Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines

Detalhes bibliográficos
Autor(a) principal: Carvalho, Jóni Costa
Data de Publicação: 2021
Outros Autores: Cunha, Francisca, Coutinho, Iolanda Alen, Loureiro, Carlos, Faria, Emília, Bom, Ana Todo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096
Resumo: The first reports of hypersensitivity reactions following the rollout of COVID-19 vaccination programs have raised public concern. Given the recent availability and novel mechanisms of COVID-19 vaccines, there is limited data on possible hypersensitivity reactions. Although it seems rare, the incidence of anaphylaxis for approved COVID-19 vaccines has been suggested as being higher when compared to previous vaccines. Adequate risk assessment, recognition, classification, and management of hypersensitivity reactions is crucial to ensure safe immunization and avoid misinformation and vaccine hesitancy. In this review, we present an overview of the types of hypersensitivity reactions that can potentially occur due to vaccination and the possible allergenic components of COVID-19 vaccines, as well as a suggestion for causality and risk assessment for the BNT162b2, mRNA-1273 and AZD1222 vaccines.
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spelling Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 VaccinesReações de Hipersensibilidade a Vacinas: Evidência Atual e Recomendações para as Vacinas SARS-CoV-2AnaphylaxisCOVID-19 VaccinesHypersensitivitySARS-CoV-2AnafilaxiaHipersensibilidadeSARS-CoV-2Vacinas contra COVID-19The first reports of hypersensitivity reactions following the rollout of COVID-19 vaccination programs have raised public concern. Given the recent availability and novel mechanisms of COVID-19 vaccines, there is limited data on possible hypersensitivity reactions. Although it seems rare, the incidence of anaphylaxis for approved COVID-19 vaccines has been suggested as being higher when compared to previous vaccines. Adequate risk assessment, recognition, classification, and management of hypersensitivity reactions is crucial to ensure safe immunization and avoid misinformation and vaccine hesitancy. In this review, we present an overview of the types of hypersensitivity reactions that can potentially occur due to vaccination and the possible allergenic components of COVID-19 vaccines, as well as a suggestion for causality and risk assessment for the BNT162b2, mRNA-1273 and AZD1222 vaccines.Após o início dos programas de vacinação contra a COVID-19, os primeiros relatos de reações de hipersensibilidade suscitaram alguma preocupação. Dada a recente disponibilidade e os novos mecanismos das vacinas contra a COVID-19, existem poucos dados relativos a possíveis reações de hipersensibilidade. A incidência de anafilaxia às vacinas COVID-19 parece ser mais elevada comparativamente a vacinas anteriores, embora seja igualmente rara. Uma avaliação adequada dos riscos, reconhecimento, classificação e correta abordagem das reações de hipersensibilidade é crucial para garantir uma imunização segura e evitar desinformação e hesitação na vacinação. Nesta revisão, apresentamos uma visão geral das potenciais reações de hipersensibilidade que podem ocorrer após a vacinação com as vacinas BNT162b2, mRNA-1273 e AZD1222, os seus possíveis constituintes alergénicos, bem como uma sugestão de avaliação do risco em doentes alérgicos e causalidade.Ordem dos Médicos2021-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096oai:ojs.www.actamedicaportuguesa.com:article/16096Acta Médica Portuguesa; Vol. 34 No. 7-8 (2021): July-August; 541-547Acta Médica Portuguesa; Vol. 34 N.º 7-8 (2021): Julho-Agosto; 541-5471646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/6355https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13353https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13427https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13480Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCarvalho, Jóni CostaCunha, FranciscaCoutinho, Iolanda AlenLoureiro, CarlosFaria, EmíliaBom, Ana Todo2022-12-20T11:07:44Zoai:ojs.www.actamedicaportuguesa.com:article/16096Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:45.015804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
Reações de Hipersensibilidade a Vacinas: Evidência Atual e Recomendações para as Vacinas SARS-CoV-2
title Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
spellingShingle Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
Carvalho, Jóni Costa
Anaphylaxis
COVID-19 Vaccines
Hypersensitivity
SARS-CoV-2
Anafilaxia
Hipersensibilidade
SARS-CoV-2
Vacinas contra COVID-19
title_short Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
title_full Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
title_fullStr Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
title_full_unstemmed Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
title_sort Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
author Carvalho, Jóni Costa
author_facet Carvalho, Jóni Costa
Cunha, Francisca
Coutinho, Iolanda Alen
Loureiro, Carlos
Faria, Emília
Bom, Ana Todo
author_role author
author2 Cunha, Francisca
Coutinho, Iolanda Alen
Loureiro, Carlos
Faria, Emília
Bom, Ana Todo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Jóni Costa
Cunha, Francisca
Coutinho, Iolanda Alen
Loureiro, Carlos
Faria, Emília
Bom, Ana Todo
dc.subject.por.fl_str_mv Anaphylaxis
COVID-19 Vaccines
Hypersensitivity
SARS-CoV-2
Anafilaxia
Hipersensibilidade
SARS-CoV-2
Vacinas contra COVID-19
topic Anaphylaxis
COVID-19 Vaccines
Hypersensitivity
SARS-CoV-2
Anafilaxia
Hipersensibilidade
SARS-CoV-2
Vacinas contra COVID-19
description The first reports of hypersensitivity reactions following the rollout of COVID-19 vaccination programs have raised public concern. Given the recent availability and novel mechanisms of COVID-19 vaccines, there is limited data on possible hypersensitivity reactions. Although it seems rare, the incidence of anaphylaxis for approved COVID-19 vaccines has been suggested as being higher when compared to previous vaccines. Adequate risk assessment, recognition, classification, and management of hypersensitivity reactions is crucial to ensure safe immunization and avoid misinformation and vaccine hesitancy. In this review, we present an overview of the types of hypersensitivity reactions that can potentially occur due to vaccination and the possible allergenic components of COVID-19 vaccines, as well as a suggestion for causality and risk assessment for the BNT162b2, mRNA-1273 and AZD1222 vaccines.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096
oai:ojs.www.actamedicaportuguesa.com:article/16096
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/16096
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/6355
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13353
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13427
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16096/13480
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 34 No. 7-8 (2021): July-August; 541-547
Acta Médica Portuguesa; Vol. 34 N.º 7-8 (2021): Julho-Agosto; 541-547
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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