Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer

Detalhes bibliográficos
Autor(a) principal: Rocha-Rodrigues, S
Data de Publicação: 2021
Outros Autores: Matos, M, Afonso, J, Mendes-Ferreira, M, Abade, E, Teixeira, E, Silva, B, Murawska-Cialowicz, E, Oliveira, MJ, Ribeiro, R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152475
Resumo: Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo-and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.
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spelling Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancerCancerPeriprostatic fatPhysical activitySkeletal muscleTumor microenvironmentVisceral adiposityIncreased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo-and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.MDPI20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152475eng1661-659610.3390/ijms22094469Rocha-Rodrigues, SMatos, MAfonso, JMendes-Ferreira, MAbade, ETeixeira, ESilva, BMurawska-Cialowicz, EOliveira, MJRibeiro, Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-01T01:18:15ZPortal AgregadorONG
dc.title.none.fl_str_mv Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
title Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
spellingShingle Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
Rocha-Rodrigues, S
Cancer
Periprostatic fat
Physical activity
Skeletal muscle
Tumor microenvironment
Visceral adiposity
title_short Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
title_full Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
title_fullStr Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
title_full_unstemmed Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
title_sort Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercise training in prostate cancer
author Rocha-Rodrigues, S
author_facet Rocha-Rodrigues, S
Matos, M
Afonso, J
Mendes-Ferreira, M
Abade, E
Teixeira, E
Silva, B
Murawska-Cialowicz, E
Oliveira, MJ
Ribeiro, R
author_role author
author2 Matos, M
Afonso, J
Mendes-Ferreira, M
Abade, E
Teixeira, E
Silva, B
Murawska-Cialowicz, E
Oliveira, MJ
Ribeiro, R
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha-Rodrigues, S
Matos, M
Afonso, J
Mendes-Ferreira, M
Abade, E
Teixeira, E
Silva, B
Murawska-Cialowicz, E
Oliveira, MJ
Ribeiro, R
dc.subject.por.fl_str_mv Cancer
Periprostatic fat
Physical activity
Skeletal muscle
Tumor microenvironment
Visceral adiposity
topic Cancer
Periprostatic fat
Physical activity
Skeletal muscle
Tumor microenvironment
Visceral adiposity
description Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo-and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152475
url https://hdl.handle.net/10216/152475
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
10.3390/ijms22094469
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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