Effects of apigenin on gastric cancer cells

Detalhes bibliográficos
Autor(a) principal: Pratas, Ana
Data de Publicação: 2024
Outros Autores: Malhão, Beatriz, Palma, Raquel, Mendonça, Paula, Cervantes, Renata, Marques-Ramos, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/17102
Resumo: The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.
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spelling Effects of apigenin on gastric cancer cellsApigeninApoptosisCell proliferationGastric cancerMolecular targetsIPL/2021/GATumor_ESTeSLFCT_UIDB/05608/2020FCT_UIDP/05608/2020The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.Gastric Cancer (GC) is one of the most prevalent cancers worldwide. As the currently available therapeutic options are invasive, new and more benign options are being explored. One of which is Apigenin (Api), a natural flavonoid found in fruits and vegetables, such as celery, parsley, garlic, bell pepper, and chamomile tea. Api has known anti-inflammatory, -oxidant, and -proliferative properties in several diseases, and its potential as an anticancer compound has been explored. Here we systematize the available data regarding the effects of Api on GC cells, in terms of cell proliferation, apoptosis, Helicobacter pylori (H. pylori) infection, and molecular targets. From the literature, it is possible to conclude that Api inhibits cell growth in a dose- and time-dependent manner, which is accompanied by the reduction of clone formation and induction of apoptosis. This occurs through the Akt/Bad/Bcl2/Bax axis that activates the mitochondrial pathway of apoptosis, resulting in the restriction of cell proliferation. Additionally, it seems that the anti-proliferative potential of Api on GC cells is particularly relevant in a more aggressive GC phenotype but can also affect normal gastric cells. This indicates that this flavonoid must be used in low-to-moderate doses to avoid side effects induced by disturbance of the normal epithelium. In H. Pylori-infected cells, the literature demonstrates that Api reduces inflammation by diminishing the levels of H. pylori colonization, preventing NF-kB activation, and diminishing the production of reactive oxygen specimens (ROS). Accordingly, GC Api seems to regulate different hallmarks of cancer, such as cell proliferation, apoptosis, cell migration, inflammation, and oxidative stress, demonstrating its potential as an anti-GC compound.ElsevierRCIPLPratas, AnaMalhão, BeatrizPalma, RaquelMendonça, PaulaCervantes, RenataMarques-Ramos, Ana2024-02-12T12:26:27Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/17102engPratas A, Malhão B, Palma R, Mendonça P, Cervantes R, Marques-Ramos A. Effects of apigenin on gastric cancer cells. Biomed Pharmacother. 2024;172:116251.10.1016/j.biopha.2024.116251info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-21T02:17:14Zoai:repositorio.ipl.pt:10400.21/17102Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:38:13.077458Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of apigenin on gastric cancer cells
title Effects of apigenin on gastric cancer cells
spellingShingle Effects of apigenin on gastric cancer cells
Pratas, Ana
Apigenin
Apoptosis
Cell proliferation
Gastric cancer
Molecular targets
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Effects of apigenin on gastric cancer cells
title_full Effects of apigenin on gastric cancer cells
title_fullStr Effects of apigenin on gastric cancer cells
title_full_unstemmed Effects of apigenin on gastric cancer cells
title_sort Effects of apigenin on gastric cancer cells
author Pratas, Ana
author_facet Pratas, Ana
Malhão, Beatriz
Palma, Raquel
Mendonça, Paula
Cervantes, Renata
Marques-Ramos, Ana
author_role author
author2 Malhão, Beatriz
Palma, Raquel
Mendonça, Paula
Cervantes, Renata
Marques-Ramos, Ana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Pratas, Ana
Malhão, Beatriz
Palma, Raquel
Mendonça, Paula
Cervantes, Renata
Marques-Ramos, Ana
dc.subject.por.fl_str_mv Apigenin
Apoptosis
Cell proliferation
Gastric cancer
Molecular targets
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Apigenin
Apoptosis
Cell proliferation
Gastric cancer
Molecular targets
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-12T12:26:27Z
2024-02
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/17102
url http://hdl.handle.net/10400.21/17102
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pratas A, Malhão B, Palma R, Mendonça P, Cervantes R, Marques-Ramos A. Effects of apigenin on gastric cancer cells. Biomed Pharmacother. 2024;172:116251.
10.1016/j.biopha.2024.116251
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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