Familiar gastric cancer
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://revista.spcir.com/index.php/spcir/article/view/228 |
Resumo: | Gastric carcinoma shows familial clustering in 10% of the cases. In those families, the association between patterns of inheritance, the histopathological presentation of the tumours and the different models of carcinogenesis was analyzed, which culminated in the definition of a new entity, the Hereditary Diffuse Gastric Cancer. This syndrome has an autosomal dominant pattern of inheritance and is specifically associated with E-cadherin/CDH1 gene germline mutations in about one third of families displaying aggregation of diffuse gastric cancer. Mutation carriers have a 70% lifetime risk of developing diffuse gastric cancer, which is highly lethal, and female carriers have a 40% risk of developing lobular carcinoma of the breast. In this article, the current concepts and recent progress on the categorization, diagnostic approach and therapeutic intervention in Hereditary Diffuse Gastric Cancer are reviewed, highlighting the most relevant topics in clinical practice. Furthermore, the most controversial or challenging issues on this subject are discussed, namely the etiopathogenesis and the management of the other cases of familial aggregation. Keywords: gastric cancer; familial gastric cancer; E-cadherin; CDH1; hereditary diffuse gastric cancer; lobular carcinoma of the breast. |
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Familiar gastric cancerCancro gástrico familiarGastric carcinoma shows familial clustering in 10% of the cases. In those families, the association between patterns of inheritance, the histopathological presentation of the tumours and the different models of carcinogenesis was analyzed, which culminated in the definition of a new entity, the Hereditary Diffuse Gastric Cancer. This syndrome has an autosomal dominant pattern of inheritance and is specifically associated with E-cadherin/CDH1 gene germline mutations in about one third of families displaying aggregation of diffuse gastric cancer. Mutation carriers have a 70% lifetime risk of developing diffuse gastric cancer, which is highly lethal, and female carriers have a 40% risk of developing lobular carcinoma of the breast. In this article, the current concepts and recent progress on the categorization, diagnostic approach and therapeutic intervention in Hereditary Diffuse Gastric Cancer are reviewed, highlighting the most relevant topics in clinical practice. Furthermore, the most controversial or challenging issues on this subject are discussed, namely the etiopathogenesis and the management of the other cases of familial aggregation. Keywords: gastric cancer; familial gastric cancer; E-cadherin; CDH1; hereditary diffuse gastric cancer; lobular carcinoma of the breast. O carcinoma gástrico apresenta uma agregação familiar em 10% dos casos. Nessas famílias, diversos autores relacionaram padrões de hereditariedade e apresentação histopatológica dos tumores com diferentes modelos de carcinogénese, tendo definido uma nova entidade, o Cancro Gástrico Difuso Hereditário. Esta síndrome apresenta um padrão de hereditariedade autossómica dominante e associa-se especificamente a mutações germinativas do gene da caderina-E/CDH1 em cerca de um terço das famílias com agregação do carcinoma gástrico de tipo difuso em idade jovem. Os indivíduos portadores destas mutações têm uma probabilidade de 70% de virem a apresentar cancro gástrico de tipo difuso, geralmente associado a elevada letalidade. As mulheres portadoras destas mutações apresentam ainda um risco de 40% de virem a desenvolver carcinoma lobular da mama. Neste artigo, são revistos os conceitos actuais e os progressos recentes na categorização, abordagem diagnóstica e intervenção terapêutica nos casos de Cancro Gástrico Difuso Hereditário, com destaque para os aspectos mais relevantes para a prática clínica. Para além disso, abordam-se os pontos mais controversos deste tema, nomeadamente no que respeita à etiopatogénese e à actuação nos restantes casos de agregação familiar. Palavras-chave: cancro gástrico; cancro gástrico familiar; caderina-E; CDH1; cancro gástrico difuso hereditário; carcinoma lobular da mama. Sociedade Portuguesa de Cirurgia2009-03-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spcir.com/index.php/spcir/article/view/228Revista Portuguesa de Cirurgia; No 8 (2009): Março 2009 - II Série; 11-24Revista Portuguesa de Cirurgia; No 8 (2009): Março 2009 - II Série; 11-242183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spcir.com/index.php/spcir/article/view/228https://revista.spcir.com/index.php/spcir/article/view/228/227Copyright (c) 2016 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessRodrigues, Patricia Fernandes Dias de MadureiraCalado, António Herculano MoreiraOliveira, CarlaSousa, João António Pinto dePimenta, Amadeu Pinto de Araújo2023-09-07T16:46:08ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Familiar gastric cancer Cancro gástrico familiar |
title |
Familiar gastric cancer |
spellingShingle |
Familiar gastric cancer Rodrigues, Patricia Fernandes Dias de Madureira |
title_short |
Familiar gastric cancer |
title_full |
Familiar gastric cancer |
title_fullStr |
Familiar gastric cancer |
title_full_unstemmed |
Familiar gastric cancer |
title_sort |
Familiar gastric cancer |
author |
Rodrigues, Patricia Fernandes Dias de Madureira |
author_facet |
Rodrigues, Patricia Fernandes Dias de Madureira Calado, António Herculano Moreira Oliveira, Carla Sousa, João António Pinto de Pimenta, Amadeu Pinto de Araújo |
author_role |
author |
author2 |
Calado, António Herculano Moreira Oliveira, Carla Sousa, João António Pinto de Pimenta, Amadeu Pinto de Araújo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Patricia Fernandes Dias de Madureira Calado, António Herculano Moreira Oliveira, Carla Sousa, João António Pinto de Pimenta, Amadeu Pinto de Araújo |
description |
Gastric carcinoma shows familial clustering in 10% of the cases. In those families, the association between patterns of inheritance, the histopathological presentation of the tumours and the different models of carcinogenesis was analyzed, which culminated in the definition of a new entity, the Hereditary Diffuse Gastric Cancer. This syndrome has an autosomal dominant pattern of inheritance and is specifically associated with E-cadherin/CDH1 gene germline mutations in about one third of families displaying aggregation of diffuse gastric cancer. Mutation carriers have a 70% lifetime risk of developing diffuse gastric cancer, which is highly lethal, and female carriers have a 40% risk of developing lobular carcinoma of the breast. In this article, the current concepts and recent progress on the categorization, diagnostic approach and therapeutic intervention in Hereditary Diffuse Gastric Cancer are reviewed, highlighting the most relevant topics in clinical practice. Furthermore, the most controversial or challenging issues on this subject are discussed, namely the etiopathogenesis and the management of the other cases of familial aggregation. Keywords: gastric cancer; familial gastric cancer; E-cadherin; CDH1; hereditary diffuse gastric cancer; lobular carcinoma of the breast. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/228 |
url |
https://revista.spcir.com/index.php/spcir/article/view/228 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/228 https://revista.spcir.com/index.php/spcir/article/view/228/227 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Revista Portuguesa de Cirurgia info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Revista Portuguesa de Cirurgia |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
dc.source.none.fl_str_mv |
Revista Portuguesa de Cirurgia; No 8 (2009): Março 2009 - II Série; 11-24 Revista Portuguesa de Cirurgia; No 8 (2009): Março 2009 - II Série; 11-24 2183-1165 1646-6918 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777304691779043328 |