Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group

Detalhes bibliográficos
Autor(a) principal: Gampenrieder, S. P.
Data de Publicação: 2023
Outros Autores: Dezentjé, V., Lambertini, M., de Nonneville, A., Marhold, M., Le Du, F., Cortés Salgado, A., Alpuim Costa, D., Vaz Batista, M., Chic Ruché, N., Tinchon, C., Petzer, A., Blondeaux, E., Del Mastro, L., Targato, G., Bertucci, F., Gonçalves, A., Viret, F., Bartsch, R., Mannsbart, C., Deleuze, A., Robert, L., Saavedra Serrano, C., Gion Cortés, M., Sampaio-Alves, M., Vitorino, M., Pecen, L., Singer, C., Harbeck, N., Rinnerthaler, G., Greil, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147551
Resumo: Funding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The Authors
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spelling Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study GroupHER2-lowmetastaticOSprognosisreal-world datatriple-negative breast cancerOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The AuthorsBackground: Triple-negative breast cancer (TNBC) is associated with poor prognosis, and new treatment options are urgently needed. About 34%-39% of primary TNBCs show a low expression of human epidermal growth factor receptor 2 (HER2-low), which is a target for new anti-HER2 drugs. However, little is known about the frequency and the prognostic value of HER2-low in metastatic TNBC. Patients and methods: We retrospectively included patients with TNBC from five European countries for this international, multicenter analysis. Triple-negativity had to be shown in a metastatic site or in the primary breast tumor diagnosed simultaneously or within 3 years before metastatic disease. HER2-low was defined as immunohistochemically (IHC) 1+ or 2+ without ERBB2 gene amplification. Survival probabilities were calculated by the Kaplan–Meier method, and multivariable hazard ratios (HRs) were estimated by Cox regression models. Results: In total, 691 patients, diagnosed between January 2006 and February 2021, were assessable. The incidence of HER2-low was 32.0% [95% confidence interval (CI) 28.5% to 35.5%], with similar proportions in metastases (n = 265; 29.8%) and primary tumors (n = 425; 33.4%; P = 0.324). The median overall survival (OS) in HER2-low and HER2-0 TNBC was 18.6 and 16.1 months, respectively (HR 1.00; 95% CI 0.83-1.19; P = 0.969). Similarly, in multivariable analysis, HER2-low had no significant impact on OS (HR 0.95; 95% CI 0.79-1.13; P = 0.545). No difference in prognosis was observed between HER2 IHC 0/1+ and IHC 2+ tumors (HR 0.89; 95% CI 0.69-1.17; P = 0.414). Conclusions: In this large international dataset of metastatic TNBC, the frequency of HER2-low was 32.0%. Neither in univariable nor in multivariable analysis HER2-low showed any influence on OS.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGampenrieder, S. P.Dezentjé, V.Lambertini, M.de Nonneville, A.Marhold, M.Le Du, F.Cortés Salgado, A.Alpuim Costa, D.Vaz Batista, M.Chic Ruché, N.Tinchon, C.Petzer, A.Blondeaux, E.Del Mastro, L.Targato, G.Bertucci, F.Gonçalves, A.Viret, F.Bartsch, R.Mannsbart, C.Deleuze, A.Robert, L.Saavedra Serrano, C.Gion Cortés, M.Sampaio-Alves, M.Vitorino, M.Pecen, L.Singer, C.Harbeck, N.Rinnerthaler, G.Greil, R.2023-01-13T22:20:10Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147551eng2059-7029PURE: 49448338https://doi.org/10.1016/j.esmoop.2022.100747info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:28:46Zoai:run.unl.pt:10362/147551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:59.725851Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
title Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
spellingShingle Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
Gampenrieder, S. P.
HER2-low
metastatic
OS
prognosis
real-world data
triple-negative breast cancer
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
title_full Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
title_fullStr Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
title_full_unstemmed Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
title_sort Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
author Gampenrieder, S. P.
author_facet Gampenrieder, S. P.
Dezentjé, V.
Lambertini, M.
de Nonneville, A.
Marhold, M.
Le Du, F.
Cortés Salgado, A.
Alpuim Costa, D.
Vaz Batista, M.
Chic Ruché, N.
Tinchon, C.
Petzer, A.
Blondeaux, E.
Del Mastro, L.
Targato, G.
Bertucci, F.
Gonçalves, A.
Viret, F.
Bartsch, R.
Mannsbart, C.
Deleuze, A.
Robert, L.
Saavedra Serrano, C.
Gion Cortés, M.
Sampaio-Alves, M.
Vitorino, M.
Pecen, L.
Singer, C.
Harbeck, N.
Rinnerthaler, G.
Greil, R.
author_role author
author2 Dezentjé, V.
Lambertini, M.
de Nonneville, A.
Marhold, M.
Le Du, F.
Cortés Salgado, A.
Alpuim Costa, D.
Vaz Batista, M.
Chic Ruché, N.
Tinchon, C.
Petzer, A.
Blondeaux, E.
Del Mastro, L.
Targato, G.
Bertucci, F.
Gonçalves, A.
Viret, F.
Bartsch, R.
Mannsbart, C.
Deleuze, A.
Robert, L.
Saavedra Serrano, C.
Gion Cortés, M.
Sampaio-Alves, M.
Vitorino, M.
Pecen, L.
Singer, C.
Harbeck, N.
Rinnerthaler, G.
Greil, R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Gampenrieder, S. P.
Dezentjé, V.
Lambertini, M.
de Nonneville, A.
Marhold, M.
Le Du, F.
Cortés Salgado, A.
Alpuim Costa, D.
Vaz Batista, M.
Chic Ruché, N.
Tinchon, C.
Petzer, A.
Blondeaux, E.
Del Mastro, L.
Targato, G.
Bertucci, F.
Gonçalves, A.
Viret, F.
Bartsch, R.
Mannsbart, C.
Deleuze, A.
Robert, L.
Saavedra Serrano, C.
Gion Cortés, M.
Sampaio-Alves, M.
Vitorino, M.
Pecen, L.
Singer, C.
Harbeck, N.
Rinnerthaler, G.
Greil, R.
dc.subject.por.fl_str_mv HER2-low
metastatic
OS
prognosis
real-world data
triple-negative breast cancer
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic HER2-low
metastatic
OS
prognosis
real-world data
triple-negative breast cancer
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Funding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The Authors
publishDate 2023
dc.date.none.fl_str_mv 2023-01-13T22:20:10Z
2023-02
2023-02-01T00:00:00Z
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 2059-7029
PURE: 49448338
https://doi.org/10.1016/j.esmoop.2022.100747
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