THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4843 https://doi.org/10.1006/phrs.1999.0572 |
Resumo: | One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessing plasma and platelet catecholamines, and a possible connection to cyclosporin A-induced increased arterial blood pressure. It was thus based on an investigation in which Wistar rats were divided into three groups: one taking only orange juice (control) and the other two receiving 5 and 30 mg kg-1([`]trough' and [`]peak') of cyclosporin A (Sandimmun Neoral®), daily, for 7 weeks. Plasma and platelet noradrenaline, adrenaline and dopamine levels and arterial blood pressures were evaluated before the start of the study (week 0) and after 2, 4 and 7 weeks. Plasma and platelet catecholamines increased drastically in the [`]peak' CsA concentration-treated group, which contrasts with the slight decrease observed in the group treated with the [`]trough' concentration. However, both groups revealed an increase in blood pressures, when compared with the control group. These findings suggest that at least [`]peak' cyclosporin A concentration alters significantly the plasma and platelets catecholamines levels, which may contribute to the cyclosporin A-induced hypertension. Other contributions, regardless of catecholamine content disturbances, might occur, at least at [`]trough' CsA concentrations. |
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THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATScyclosporin, hypertension, plasma and platelet catecholaminesOne of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessing plasma and platelet catecholamines, and a possible connection to cyclosporin A-induced increased arterial blood pressure. It was thus based on an investigation in which Wistar rats were divided into three groups: one taking only orange juice (control) and the other two receiving 5 and 30 mg kg-1([`]trough' and [`]peak') of cyclosporin A (Sandimmun Neoral®), daily, for 7 weeks. Plasma and platelet noradrenaline, adrenaline and dopamine levels and arterial blood pressures were evaluated before the start of the study (week 0) and after 2, 4 and 7 weeks. Plasma and platelet catecholamines increased drastically in the [`]peak' CsA concentration-treated group, which contrasts with the slight decrease observed in the group treated with the [`]trough' concentration. However, both groups revealed an increase in blood pressures, when compared with the control group. These findings suggest that at least [`]peak' cyclosporin A concentration alters significantly the plasma and platelets catecholamines levels, which may contribute to the cyclosporin A-induced hypertension. Other contributions, regardless of catecholamine content disturbances, might occur, at least at [`]trough' CsA concentrations.http://www.sciencedirect.com/science/article/B6WP9-45C0VWC-14/1/5cb37b6b1a76a1737f1ac8d05b92b1f62000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4843http://hdl.handle.net/10316/4843https://doi.org/10.1006/phrs.1999.0572engPharmacological Research. 41:2 (2000) 129-135Reis, F.Tavares, P.Teixeira, F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:48:39ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
title |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
spellingShingle |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS Reis, F. cyclosporin, hypertension, plasma and platelet catecholamines |
title_short |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
title_full |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
title_fullStr |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
title_full_unstemmed |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
title_sort |
THE DISTRIBUTION OF CATECHOLAMINES BETWEEN PLASMA AND PLATELETS IN CYCLOSPORIN A-INDUCED HYPERTENSIVE RATS |
author |
Reis, F. |
author_facet |
Reis, F. Tavares, P. Teixeira, F. |
author_role |
author |
author2 |
Tavares, P. Teixeira, F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Reis, F. Tavares, P. Teixeira, F. |
dc.subject.por.fl_str_mv |
cyclosporin, hypertension, plasma and platelet catecholamines |
topic |
cyclosporin, hypertension, plasma and platelet catecholamines |
description |
One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessing plasma and platelet catecholamines, and a possible connection to cyclosporin A-induced increased arterial blood pressure. It was thus based on an investigation in which Wistar rats were divided into three groups: one taking only orange juice (control) and the other two receiving 5 and 30 mg kg-1([`]trough' and [`]peak') of cyclosporin A (Sandimmun Neoral®), daily, for 7 weeks. Plasma and platelet noradrenaline, adrenaline and dopamine levels and arterial blood pressures were evaluated before the start of the study (week 0) and after 2, 4 and 7 weeks. Plasma and platelet catecholamines increased drastically in the [`]peak' CsA concentration-treated group, which contrasts with the slight decrease observed in the group treated with the [`]trough' concentration. However, both groups revealed an increase in blood pressures, when compared with the control group. These findings suggest that at least [`]peak' cyclosporin A concentration alters significantly the plasma and platelets catecholamines levels, which may contribute to the cyclosporin A-induced hypertension. Other contributions, regardless of catecholamine content disturbances, might occur, at least at [`]trough' CsA concentrations. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4843 http://hdl.handle.net/10316/4843 https://doi.org/10.1006/phrs.1999.0572 |
url |
http://hdl.handle.net/10316/4843 https://doi.org/10.1006/phrs.1999.0572 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacological Research. 41:2 (2000) 129-135 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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