High fat diet blunts the effects of leptin on ventilation and on carotid body activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/149318 |
Resumo: | Funding : This study was supported by the Portuguese Foundation for Science and Technology grant PTDC/SAU-ORG/111417/2009 to S.C. and by Grants BFU2015-70616R from MINECO-FEDER, Spain. J.F.S. and B.F.M. are supported by PhD Grants from FCT, PD/BD/105890/2014 and PD/BD/128336/2017, respectively. |
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High fat diet blunts the effects of leptin on ventilation and on carotid body activityventilationleptincarotid bodycarotid sinus nerveadenosineFunding : This study was supported by the Portuguese Foundation for Science and Technology grant PTDC/SAU-ORG/111417/2009 to S.C. and by Grants BFU2015-70616R from MINECO-FEDER, Spain. J.F.S. and B.F.M. are supported by PhD Grants from FCT, PD/BD/105890/2014 and PD/BD/128336/2017, respectively.Leptin plays a role in the control of breathing, acting mainly on central nervous structures. Leptin receptor is expressed in the carotid body (CB) and this finding has been associated with a putative physiological role of leptin in the regulation of CB function. Since, the CBs are implicated in energy metabolism herein we tested the effects of different concentrations of leptin administration on ventilatory parameters and on carotid sinus nerve (CSN) activity in control and high-fat (HF) diet fed rats, in order to clarify the role of leptin in ventilation control in metabolic disease states. We also investigated the expression of leptin receptors and the neurotransmitters involved in leptin signalling in the CBs. We found that in non-disease conditions, leptin increases minute ventilation both in basal and hypoxic conditions. However, in the HF model, the effect of leptin in ventilatory control is blunted. We also observed that HF rats display an increased frequency of CSN discharge in basal conditions that is not altered by leptin, in contrast to what is observed in control animals. Leptin did not modify intracellular Ca2+ in CB chemoreceptor cells, but it produced an increase in the release of adenosine from the whole CB. We conclude that CBs represent an important target for leptin signalling, not only to coordinate peripheral ventilatory chemoreflexive drive, but probably also to modulate metabolic variables. We also concluded that leptin signalling is mediated by adenosine release and that HF diets blunt leptin responses in the CB, compromising ventilatory adaptation. This article is protected by copyright. All rights reserved.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRibeiro, Maria JSacramento, Joana FGallego-Martin, TeresaOlea, ElenaMelo, Bernardete FGuarino, Maria PYubero, SaraObeso, AnaConde, Silvia V2023-02-16T22:13:59Z2018-08-012018-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/149318eng0022-3751PURE: 3409573https://doi.org/10.1113/JP275362info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:16Zoai:run.unl.pt:10362/149318Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:43.219101Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| title |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| spellingShingle |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity Ribeiro, Maria J ventilation leptin carotid body carotid sinus nerve adenosine |
| title_short |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| title_full |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| title_fullStr |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| title_full_unstemmed |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| title_sort |
High fat diet blunts the effects of leptin on ventilation and on carotid body activity |
| author |
Ribeiro, Maria J |
| author_facet |
Ribeiro, Maria J Sacramento, Joana F Gallego-Martin, Teresa Olea, Elena Melo, Bernardete F Guarino, Maria P Yubero, Sara Obeso, Ana Conde, Silvia V |
| author_role |
author |
| author2 |
Sacramento, Joana F Gallego-Martin, Teresa Olea, Elena Melo, Bernardete F Guarino, Maria P Yubero, Sara Obeso, Ana Conde, Silvia V |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Ribeiro, Maria J Sacramento, Joana F Gallego-Martin, Teresa Olea, Elena Melo, Bernardete F Guarino, Maria P Yubero, Sara Obeso, Ana Conde, Silvia V |
| dc.subject.por.fl_str_mv |
ventilation leptin carotid body carotid sinus nerve adenosine |
| topic |
ventilation leptin carotid body carotid sinus nerve adenosine |
| description |
Funding : This study was supported by the Portuguese Foundation for Science and Technology grant PTDC/SAU-ORG/111417/2009 to S.C. and by Grants BFU2015-70616R from MINECO-FEDER, Spain. J.F.S. and B.F.M. are supported by PhD Grants from FCT, PD/BD/105890/2014 and PD/BD/128336/2017, respectively. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-08-01 2018-08-01T00:00:00Z 2023-02-16T22:13:59Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/149318 |
| url |
http://hdl.handle.net/10362/149318 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0022-3751 PURE: 3409573 https://doi.org/10.1113/JP275362 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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13 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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